Patents by Inventor Yulian Wu

Yulian Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR EFFICIENTLY INDUCING REPROGRAMMING OF HUMAN CELL INTO NEURONAL CELL
    Publication number: 20240034991
    Abstract: In a method for efficiently inducing reprogramming of human cells into neuronal cells, a concentration of cAMP is increased or an expression of PKA and CREB is up-regulated or an expression of AMPK, ALK2, ALK3, P38, and JNK is inhibited by a single small molecule compound or gene knockout or gene overexpression. In the present disclosure, the induction small molecule compound is single and safe, and has a short induction time, high induction efficiency, definite induction sites and genes, and clear molecular regulation mechanism. The small molecule compound can be applied to the clinical treatment of human neurodegenerative diseases, providing a safer and more efficient treatment method for the neurodegenerative diseases. Since neuronal cells cannot divide and proliferate, the method induces fibroblasts and astrocytes that can divide and proliferate in vitro and in vivo, to continuously obtain a large number of induced neuronal cells in vitro and in vivo.
    Type: Application
    Filed: July 27, 2022
    Publication date: February 1, 2024
    Applicants: GUANGXI UNIVERSITY, Guangxi Benpeng Biotechnology Co., Ltd.
    Inventors: Ben HUANG, Guodong WANG, Dandan ZHANG, Quanhui LIU, Yulian WU, Danwei LV, Jigang HU, Xiaolian XIE
  • Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts
    Patent number: 8686185
    Abstract: The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylamino benzoic acid derivatives represented by specific Chemical formulas or their salts, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino]benzoic acid or its salt.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: April 1, 2014
    Assignee: Neurotech Pharmaceuticals Co., Ltd.
    Inventors: Byoung Joo Gwag, Jae Young Cho, Young Ae Lee, Cheng Qiling, Yulian Wu, Li Xing
  • MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS
    Publication number: 20110028757
    Abstract: The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylaminobenzoic acid derivative represented by the specific Chemical formula or its salt, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino] benzoic acid or its salt.
    Type: Application
    Filed: October 30, 2008
    Publication date: February 3, 2011
    Applicant: NEUROTECH PHARMACEUTICALS CO., LTD.
    Inventors: Byoung Joo Gwag, Jae Young Cho, Young Ae Lee, Cheng Qiling, Yulian Wu, Li Xing
  • Diagnostic and prognostic methods and compositions of matter for cell proliferative diseases
    Publication number: 20080026411
    Abstract: A method for diagnosing a cell proliferative disease expressing DcR3/TR6 in a patient, which comprises the step of measuring the concentration of DcR3/TR6 in the patient's blood, plasma or serum sample, wherein a concentration of DcR3/TR6 higher than that present in the serum of a patient not suffering of a proliferative disease expressing DcR3/TR6 is indicative of that patient suffering from said disease. Methods of prognosing said diseases and compositions of matters for use in said diseases.
    Type: Application
    Filed: September 3, 2004
    Publication date: January 31, 2008
    Inventors: Jiangping Wu, Yulian Wu