Patents by Inventor Yuling Li

Yuling Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human chemokine beta-10 mutant polypeptides
    Publication number: 20030022314
    Abstract: Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
    Type: Application
    Filed: April 19, 2002
    Publication date: January 30, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Henrik S. Olsen, Haodong Li, Mark D. Adams, Solange H. L. Gentz, Ralph Alderson, Yuling Li, David Parmelee, John R. White, Edward R. Appelbaum
  • Human chemokine beta-10 mutant polypeptides
    Patent number: 6391589
    Abstract: Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: May 21, 2002
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham, Corp.
    Inventors: Henrik S. Olsen, Haodong Li, Mark D. Adams, Solange H. L. Gentz, Ralph Alderson, Yuling Li, David Parmelee, John R. White, Edward R. Appelbaum
  • Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4
    Patent number: 6174995
    Abstract: Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: January 16, 2001
    Inventors: Haodong Li, Mark Adams, Solange Hanschke Lima, Ralph Alderson, Yuling Li, David Parmelee, John White, Edward Applebaum
  • Method of purifying chemokines from inclusion bodies
    Patent number: 5912327
    Abstract: The present invention relates to processes for the purification of proteins. More specifically, methods for solubilizing and purifying proteins expressed in an insoluble form using low concentrations of chaotropic agents, such as guanidine salts, are provided. Also provided are methods for refolding proteins solubilized according to the present invention.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: June 15, 1999
    Assignee: Human Genome Sciences, Inc.
    Inventors: Yuling Li, Mark Oelkuct, Reiner L. Gentz