Abstract: An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases, and the present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof, where each symbol in Formula (1) has the same definition as that described in the specification.

Abstract: A technique disclosed herein relates to a method for producing a plate piece including a partial outline and a remaining outline continuous from the partial outline. The method disclosed herein may comprise removing an outer region external to the partial outline from a plate workpiece by a first punch (first punching process); and punching out an inner region internal to the remaining outline by a second punch from the plate workpiece in which the outer region has been removed while applying a block to a side surface of the plate workpiece along the partial outline (second punching process). In the second punching process, by applying the block to the side surface of the already-formed partial outline, deformation of the partial outline can be suppressed when the inner region internal to the remaining outline is punched out by the second punch.