Abstract: An apparatus is provided comprising an image acquisition unit which acquires an image capturing a state of a flow channel in a flow reactor through which a fluid flows to be reacted, and a detection unit which detects liquid leakage in the flow channel based on the acquired image. The apparatus comprises a detection member for detecting liquid leakage in the flow channel, the image acquisition unit acquires an image of the detection member, and the detection unit detects liquid leakage in the flow channel based on the image of the detection member. The detection member includes ground glass. The detection member is arranged below the flow channel, the image acquisition unit acquires an image of ground glass, and the detection unit detects liquid leakage in the flow channel in response to sensing variation in at least one of color or brightness in the image of the ground glass.

Abstract: The present invention provides a means for producing a peptide with a small number of steps in a short time.

Abstract: A method for producing an asymmetric phosphoric acid triester using a flow reactor, the method including step (A1) of reacting phosphorus trichloride or phosphorus tribromide with a first hydroxy compound; step (B1) of reacting the compound obtained in the step (A1) with a second hydroxy compound; step (C1) of reacting the compound obtained in the step (B1) with a third hydroxy compound; and step (D1) of oxidizing the compound obtained in the step (C1), in which the reaction temperature in the steps (A1) and (B1) is ?80° C. or higher, and in the steps (A1) and (B1), the flow rate of each of the phosphorus trichloride or phosphorus tribromide, the first hydroxy compound, and the second hydroxy compound flowing in a flow channel is 0.01 mL/min or more.

Abstract: A reaction analysis device specifies a reaction state of a reaction fluid flowing through a flow reactor. The reaction analysis device includes a processor configured to specify the reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid which is obtained from a temperature distribution of the reaction fluid immediately after a reaction starts in a flow direction of the reaction fluid.

Abstract: A method for producing an amide, including mixing a first composition containing a carboxylic acid or a carboxylic acid active species, and an organic solvent and a second composition containing an amine having at least one carboxyl group and water and causing the carboxylic acid or the carboxylic acid active species to react with the amine to obtain an amide.

Abstract: A method for producing an amide includes: subjecting carboxylic acids to dehydration condensation or causing a reaction between a carboxylic acid and a haloformic acid ester; and subsequently causing a reaction with a first base and a reaction with an amine to obtain an amide, wherein the reaction with a first base and/or the reaction with an amine is performed by adding an acid thereto.

Abstract: A reaction analysis device specifies a reaction state of a reaction fluid flowing through a flow reactor. The reaction analysis device includes a processor configured to specify the reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid which is obtained from a temperature distribution of the reaction fluid immediately after a reaction starts in a flow direction of the reaction fluid.

Abstract: A method for producing an amide includes: reacting arginines, arginine derivatives or arginine analogs in which two amino groups or imino groups in the side chain are protected by protecting groups with a halogenated formate ester and then reacting with an amine.

Abstract: A method for producing an amide includes: dehydrating and condensing carboxylic acids and then reacting them with a base, and reacting them with an amine.