Abstract: A translocation-simulating loading apparatus for the gear grinding machine with the shaped grinding wheel is provided. The apparatus includes a load-receiving test piece disposed on the gear grinding machine with the shaped grinding wheel and a load-exerting component for use in loading simulation. The gear grinding machine enables linear movements along the X, Y, and Z axes, a rotary movement around the Y axis, a rotary movement C around the Z axis, and a rotary movement A around the X axis. An angle ? is formed between the axis L of a ball seat of the load-exerting component and the X axis direction of a Y axis component and an angle formed between the normal line of a load receiving face a and the X direction of the coordinate system of the machine tool is ?. A detection method for static stiffness distribution is provided.

Abstract: A serially-connected ball screw pair and piezoelectric actuator macro-micro driving and guiding device includes, from the bottom to the top, a sliding seat (1), a ball screw pair, a sliding table guide rail pairs, a nut seat (6), a piezoelectric actuator (7), a micro-moving table, a nut seat guide rail pairs and a sliding table (1). The axis of a ball screw is symmetric with respect to two sliding table rail pairs, a nut (3) of the ball screw pair is fixedly mounted into the nut seat (6), one end of the piezoelectric actuator (7) is fixedly connected with the nut seat (6) and the other end thereof is fixedly connected with the micro-moving table (8), the axis of the piezoelectric actuator is symmetric relative to two sliding table rail pairs, an upper surface of the micro-moving table is fixedly mounted to a lower surface of the sliding table, and two nut rail pairs are symmetric relative to the axis of the ball screw.

Abstract: The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.

Abstract: The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.

Abstract: The present invention discloses a device for detecting axis coplanarity of orthogonal rotary shafts having a built-in intersection, wherein a front assembly rotary body is coaxially connected on a front assembly housing, the front assembly rotary body and a rear assembly housing are fixedly connected with each other, the rear assembly rotary body is mounted in the rear assembly housing, a first three dimension movement fine tuning mechanism is mounted at an end of the rear assembly rotary body, the first three dimension movement fine tuning mechanism is connected with a standard sphere through a connecting rod, the three dimension movement fine tuning mechanisms are provided in the horizontal direction of the standard sphere and below the standard sphere in vertical direction, and two non-contact displacement sensors are mounted on said two three dimension movement fine tuning mechanisms respectively.

Abstract: The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.

Abstract: A biaxial linear-motion micro drive apparatus includes: a mounting base A on an upper surface of a Z-direction sliding base; a Z-direction micro actuator fixed within the mounting base A and connected with a Z-direction micro-motion platform connected with an X-direction sliding base; Z-direction guide rail strips arranged on the Z-direction sliding; two Z-direction guide rail blocks provided on one Z-direction guide rail strip fixedly mounted on a lower surface of the X-direction sliding base; a mounting base B provided on an upper surface of the X-direction sliding base; an X-direction micro actuator in the mounting base B and connected with an X-direction micro-motion platform connected with an XZ biaxial motion platform; two X-direction guide rail strips arranged on the upper surface of the X-direction sliding base; two X-direction guide rail blocks provided on each X-direction guide rail strip mounted on a lower surface of the XZ biaxial motion platform.

Abstract: A computer numerical control machine tool for grinding two sides of a plane by shifting self-rotation ultrasonic vibration, wherein a pillar (3) is provided on the tool body (1) of the machine tool, a Y axis movement assembly (12) is provided on the platform of the tool body (1), with a lower revolving movement assembly (11), which revolves about a Z coordinate axis, being mounted on the upper surface of the Y axis movement assembly (12), and a lower grinding plate (10) being mounted coaxially above the lower revolving movement assembly (11); an ultrasonic vibration assembly (2) is mounted fixedly on the pillar (3), with a separation plate (8) for clamping a workpiece assembly (9) being provided on the ultrasonic vibration assembly (2); an X axis movement assembly (4) is mounted on the upper part of the pillar (3), a Z axis movement assembly (5) is mounted on the upright face of the X axis movement assembly (4), with an upper revolving movement assembly (6), which revolves about the Z coordinate axis, being p

Abstract: Disclosed is a processing center multi-axis joint deflection loading apparatus comprising a load-receiving test piece and a load-exerting component. The load-exerting component is constituted by a steel ball, a cap, a ball socket, a bent board, a force sensor, a connection component A, and a connection component B. The connection component A is fixedly connected to a blade handle of the processing center; the blade handle is pulled tight within a bored hole on a main axle; and the connection component A is connected to a main housing via the connection component B.

Abstract: A translocation-simulating loading apparatus for gear grinding machine with shaped grinding wheel is provided. The apparatus comprises a load-receiving test piece (25) disposed on the gear grinding machine with shaped grinding wheel and a load-exerting component for use in loading simulation. The gear grinding machine with shaped grinding wheel enables a linear movement along the X axis, a linear movement forward and backward along the Y axis, a linear movement along the Z axis, a rotary movement n around the Y axis, a rotary movement C around the Z axis, and a rotary movement A around the X axis. An angle ? is formed between the axis L of a ball seat (17) of the load-exerting component and the X axis direction of a Y axis component (6); an angle formed between the normal line of a load receiving face a and the X direction of the coordinate system of the machine tool is ?. A detection method for static stiffness distribution is provided.

Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.

Abstract: The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of protein-protein interactions in vivo and in vitro. Advantages offered by various embodiments of the inventive system and methods compared to existing photocrosslinking approaches include, for example, (i) novel reversible crosslinking reagents that allow easy isolation, purification, and enrichment of the crosslinked products; (ii) trifluoromethyl phenyldiazirine- or perfluorinated phenylazide-based photocrosslinking reagents that provide high specific labeling, no side product, and higher photocrosslinking efficiency; (iii) versatile spacer groups that allow systematic contact site mapping; (iv) novel methods for isolating, purifying, and detecting crosslinked products based on the reversible-link chemistry; and (v) the ability to study the interaction sites in vitro, in situ, or in vivo.

Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.

Abstract: The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications.

Abstract: The invention provides compositions and methods for the detection and/or quantification of biological targets (e.g., nucleic acids and proteins) by the nucleic acid-templated creation of one or more reaction products, for example, epitopes, enzyme substrates, enzyme activators, and ligands. The reaction products can be detected and/or quantitated after signal amplification using an amplification system.

Abstract: The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics.

Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.

Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.