Patents by Inventor Yumiko Shibouta
Yumiko Shibouta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7135490Abstract: A treatment for glomerulonephritis is disclosed comprising administering (±)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1 -[[2?-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate.Type: GrantFiled: October 2, 2003Date of Patent: November 14, 2006Assignee: Takeda Pharmaceutical Company, LimitedInventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Publication number: 20040082636Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) 1Type: ApplicationFiled: October 2, 2003Publication date: April 29, 2004Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 6686383Abstract: This invention relates to methods for the prophylaxis or treatment of diabetic nephropathy comprising, administering as an active ingredient, a compound, or salt thereof, of formula (I) wherein R1 stands for H or lower alkyl; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring; Y stands for a bond, —O—, —S(O)m— wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group).Type: GrantFiled: August 26, 2002Date of Patent: February 3, 2004Assignee: Takeda Chemical Industries, LTDInventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Publication number: 20030114509Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) 1Type: ApplicationFiled: August 26, 2002Publication date: June 19, 2003Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 6469037Abstract: This invention relates to methods for lowering urinary total protein comprising, administering as an active ingredient, a compound or salt thereof represented by general formula (I) wherein R1 stands for H or alkyl; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R2; Y stands for a bond, —O—, —S(O)m— wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group.Type: GrantFiled: October 16, 2001Date of Patent: October 22, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Publication number: 20020045652Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general fornula (I) 1Type: ApplicationFiled: October 16, 2001Publication date: April 18, 2002Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Publication number: 20010051631Abstract: Tricyclic compound of the formula: 1Type: ApplicationFiled: June 4, 2001Publication date: December 13, 2001Inventors: Muneo Takatani, Yumiko Shibouta, Kiminori Tomimatsu, Tetsuji Kawamoto
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Patent number: 6319938Abstract: Prophylactic or therapeutic drugs for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by formula (I) wherein R1 stands for H or an optionally substituted hydrocarbon residue; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R2; Y stands for a bond, —O—, —S(O)m—, wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group are disclosed.Type: GrantFiled: December 20, 1999Date of Patent: November 20, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 6251905Abstract: Tricyclic compound of the formula: wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.Type: GrantFiled: January 21, 1999Date of Patent: June 26, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yumiko Shibouta, Kiminori Tomimatsu, Tetsuji Kawamoto
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Patent number: 6235731Abstract: A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is —Y0—Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group; Y0 is a bond or an optionally substituted bivalent hydrocarbon group; Z0 is a basic group which may be bonded via oxygen, nitrogen, —CO—, —CS—, —SO2N(R3)— (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2); ......... is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.Type: GrantFiled: October 8, 1998Date of Patent: May 22, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Yumiko Shibouta, Yasuo Sugiyama, Tetsuji Kawamoto, Muneo Takatani
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Patent number: 6040324Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).Type: GrantFiled: December 8, 1998Date of Patent: March 21, 2000Assignee: Takeda Chemical Industries, Inc.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 5958942Abstract: Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R.sup.1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.Type: GrantFiled: January 14, 1997Date of Patent: September 28, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yumiko Shibouta, Kiminori Tomimatsu, Tetsuji Kawamoto
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Patent number: 5889036Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).Type: GrantFiled: November 6, 1997Date of Patent: March 30, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 5719173Abstract: This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).Type: GrantFiled: August 14, 1996Date of Patent: February 17, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Kohei Nishikawa, Yumiko Shibouta, Keiji Kubo
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Patent number: 5587383Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.Type: GrantFiled: February 10, 1995Date of Patent: December 24, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta
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Patent number: 5395839Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.Type: GrantFiled: June 9, 1993Date of Patent: March 7, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Takatani Muneo, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta
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Patent number: 5244908Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.Type: GrantFiled: July 30, 1991Date of Patent: September 14, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta