Patents by Inventor Yumin Cui

Yumin Cui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multispecific antigen binding proteins capable of binding CD19 and CD3, and use thereof
    Patent number: 12577305
    Abstract: Provided are multispecific antigen binding proteins (MSAPs) that specifically bind to CD3 and CD19. Further provided are uses of the MSAPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the MSAPs.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: March 17, 2026
    Assignee: ITabMed (HK) Limited
    Inventors: Zhihua Huang, Wuzhong Shen, Yiqun Rao, Yumin Cui, Xiaoqiang Yan
  • VALVE CORE AND WATER OUTLET APPARATUS
    Publication number: 20250354617
    Abstract: A valve core capable of directly connecting to water hoses and a water outlet apparatus are provided. The valve core includes a valve body. A water control assembly is disposed in the valve body. At least one water inlet mounting hole is defined on the valve body, the at least one water inlet mounting hole is communicated with the water control assembly and is configured to directly connect with a corresponding water inlet hose in the water hoses. A first circular hole section is disposed on the at least one water inlet mounting hole for achieving sealing connection with the corresponding water inlet hose. a limiting structure is disposed on an outer side of the valve body, the limiting structure is configured to limit the valve body to rotating in a water outlet apparatus when the valve core is mounted in the water outlet apparatus.
    Type: Application
    Filed: June 28, 2024
    Publication date: November 20, 2025
    Inventors: QINGSHUI MA, HUOSHENG ZHAN, WEIWEI CHEN, YUMIN CUI, CHUANBAO ZHU
  • Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof
    Patent number: 12460000
    Abstract: The present invention provides bispecific antigen binding proteins (BSAPs) that specifically bind to CD3 and a tumor antigen (e.g., CD19). The present invention also provides uses of the BSAPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the BSAPs.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: November 4, 2025
    Assignee: ITabMed (HK) Limited
    Inventors: Zhihua Huang, Yiqun Rao, Wuzhong Shen, Yumin Cui, Xiaoqiang Yan
  • BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
    Publication number: 20210301018
    Abstract: The present invention provides bispecific antigen binding proteins (BSAPs) that specifically bind to CD3 and a tumor antigen (e.g., CD19). The present invention also provides uses of the BSAPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the BSAPs.
    Type: Application
    Filed: September 6, 2019
    Publication date: September 30, 2021
    Inventors: Zhihua HUANG, Yiqun RAO, Wuzhong SHEN, Yumin CUI, Xiaoqiang YAN
  • Multispecific fab fusion proteins and use thereof
    Patent number: 10870701
    Abstract: The present invention provides multispecific Fab fusion proteins (MSFP) that specifically bind to CD3 and EpCAM. The present invention further provides uses of the MSFPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the MSFPs. Also provided are anti-EpCAM antibodies or antigen-binding fragments thereof.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: December 22, 2020
    Assignee: Generon (Shanghai) Corporation Ltd.
    Inventors: Yumin Cui, Zhihua Huang, Hanyang Chen, Xinfeng Zhang, Bo Qi, Xiaoqiang Yan
  • MULTISPECIFIC FAB FUSION PROTEINS AND USE THEREOF
    Publication number: 20190092862
    Abstract: The present invention provides multispecific Fab fusion proteins (MSFP) that specifically bind to CD3 and EpCAM. The present invention further provides uses of the MSFPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the MSFPs. Also provided are anti-EpCAM antibodies or antigen-binding fragments thereof.
    Type: Application
    Filed: March 15, 2017
    Publication date: March 28, 2019
    Inventors: Yumin CUI, Zhihua HUANG, Hanyang CHEN, Xinfeng ZHANG, Bo QI, Xiaoqiang YAN
  • Quinazoline compounds
    Patent number: 9168253
    Abstract: Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: October 27, 2015
    Assignee: HUTCHISON MEDIPHARMA LIMITED
    Inventors: Weihan Zhang, Wei-Guo Su, Haibin Yang, Yumin Cui, Yongxin Ren, Xiaoqiang Yan
  • Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
    Patent number: 8946249
    Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: February 3, 2015
    Assignee: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Weihan Zhang, Hong Jia, Yumin Cui, Yongxin Ren, Yang Sai, Zhenping Wu, Wenji Li, Jiangyong Shao, Zhenping Tian
  • Pyrimidine derivatives
    Patent number: 8901143
    Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: December 2, 2014
    Assignee: Hutchison MediPharma Enterprises Limited
    Inventors: Wei-Guo Su, Hong Jia, Weihan Zhang, Yumin Cui, Xiaoqiang Yan, Yongxin Ren, Jifeng Duan, Yang Sai
  • COMPOUND, CERTAIN NOVEL FORMS THEREOF, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR PREPARATION AND USE
    Publication number: 20140200232
    Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.
    Type: Application
    Filed: December 12, 2013
    Publication date: July 17, 2014
    Applicant: HUTCHISON MEDIPHARMA LIMITED
    Inventors: WEI-GUO SU, WEIHAN ZHANG, HONG JIA, YUMIN CUI, YONGXIN REN, YANG SAI, ZHENPING WU, WENJI LI, JIANGYONG SHAO, ZHENPING TIAN
  • Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
    Patent number: 8658658
    Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: February 25, 2014
    Assignee: Hutchison MediPharma Limited
    Inventors: Wei-Guo Su, Weihan Zhang, Hong Jia, Yumin Cui, Yongxin Ren, Yang Sai, Zhenping Wu, Wenji Li, Jiangyong Shao, Zhenping Tian
  • Use of substituted quinazoline compounds in treating age-related macular degeneration
    Patent number: 8497372
    Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 30, 2013
    Assignee: Hutchison Medipharma Enterprises Limited
    Inventors: Wei-Guo Su, Weihan Zhang, Xiaoqiang Yan, Yumin Cui, Yongxin Ren, Jifeng Duan
  • QUINAZOLINE COMPOUNDS
    Publication number: 20130172373
    Abstract: Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).
    Type: Application
    Filed: May 25, 2011
    Publication date: July 4, 2013
    Applicant: Hutchison Medipharma Limited
    Inventors: Weihan Zhang, Wei-Guo Su, Haibin Yang, Yumin Cui, Yongxin Ren, Xiaoqiang Yan
  • Quinazoline derivatives
    Patent number: 8426430
    Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: April 23, 2013
    Assignee: Hutchison Medipharma Enterprises Limited
    Inventors: Weihan Zhang, Wei-Guo Su, Haibin Yang, Yumin Cui, Yongxin Ren, Xiaoqiang Yan
  • Pyrimidine derivatives
    Patent number: 8349859
    Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: January 8, 2013
    Assignee: Hutchison Medipharma Enterprises Limited
    Inventors: Wei-Guo Su, Hong Jia, Weihan Zhang, Yumin Cui, Xiaoqiang Yan, Yongxin Ren, Jifeng Duan, Yang Sai
  • COMPOUND, CERTAIN NOVEL FORMS THEREOF, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR PREPARATION AND USE
    Publication number: 20120270889
    Abstract: Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.
    Type: Application
    Filed: November 23, 2010
    Publication date: October 25, 2012
    Inventors: Wei-Guo Su, Weihan Zhang, Hong Jia, Yumin Cui, Yongxin Ren, Yang Sai, Zhenping Wu, Wenji Li, Jiangyong Shao, Zhenping Tian
  • USE OF SUBSTITUTED QUINAZOLINE COMPOUNDS IN TREATING ANGIOGENESIS-RELATED DISEASES
    Publication number: 20120238572
    Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 20, 2012
    Inventors: Wei-Guo Su, Weihan Zhang, Xiaoqiang Yan, Yumin Cui, Yongxin Red, Jifeng Duan
  • Use of substituted quinazoline compounds in treating angiogenesis-related diseases
    Patent number: 8212033
    Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: July 3, 2012
    Assignee: Hutchison Medipharma Enterprises Limited
    Inventors: Wei-Guo Su, Weihan Zhang, Xiaoqiang Yan, Yumin Cui, Yongxin Ren, Jifeng Duan
  • QUINAZOLINE DERIVATIVES
    Publication number: 20110015213
    Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.
    Type: Application
    Filed: September 29, 2010
    Publication date: January 20, 2011
    Inventors: Wei-Guo Su, Weihan Zhang, Xiaoqiang Yan, Yumin Cui, Yongxin Ren, Jifeng Duan
  • Substituted quinazoline compounds and their use in treating angiogenesis-related diseases
    Patent number: 7829574
    Abstract: Substituted quinazoline compounds of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and X are defined herein. It also discloses a pharmaceutical composition containing one of these compounds.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: November 9, 2010
    Assignee: Hutchison MediPharma Enterprises Limited
    Inventors: Wei-Guo Su, Weihan Zhang, Xiaoqiang Yan, Yumin Cui, Yongxin Ren, Jifeng Duan