Patents by Inventor Yun-Chiao Yao

Yun-Chiao Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUNCTIONALIZED N-ACETYLGALACTOSAMINE ANALOGS
    Publication number: 20230279041
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: December 13, 2022
    Publication date: September 7, 2023
    Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao
  • COMPOSITIONS AND METHODS FOR LIQUID PHASE OLIGONUCLEOTIDE SYNTHESIS
    Publication number: 20230212209
    Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.
    Type: Application
    Filed: December 23, 2022
    Publication date: July 6, 2023
    Inventors: Gaomai Yang, Yun-Chiao Yao, David Yu, Aldrich N.K. Lau
  • Functionalized n-acetylgalactosamine analogs
    Patent number: 11692001
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: July 4, 2023
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau
  • Functionalized N-acetylgalactosamine nucleosides
    Patent number: 11649260
    Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: May 16, 2023
    Assignee: Hongene Biotech Corporation
    Inventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N. K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao
  • POLYMERIC SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS
    Publication number: 20230130509
    Abstract: Embodiments of the present application relate to porous polymeric beads solid support for use in oligonucleotide synthesis and the method of producing and using the same. Further embodiments relate to porous polymeric beads and method for preparing and using the same.
    Type: Application
    Filed: October 20, 2022
    Publication date: April 27, 2023
    Inventors: Jingshe Song, John Michael Cue, Yun-Chiao Yao, David Yu, Aldrich N.K. Lau
  • FUNCTIONALIZED N-ACETYLGALACTOSAMINE ANALOGS
    Publication number: 20230100220
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: August 26, 2022
    Publication date: March 30, 2023
    Inventors: Wing C. POON, Gang ZHAO, Gengyu DU, Yun-Chiao YAO, Mufa ZOU, Xiaoyang GUAN, Xiaoling ZHENG, David YU, Ruiming ZOU, Aldrich N.K. LAU
  • FUNCTIONALIZED N-ACETYLGALACTOSAMINE NUCLEOSIDES
    Publication number: 20230034284
    Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: June 16, 2022
    Publication date: February 2, 2023
    Inventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N.K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao