Patents by Inventor Yun Chung Leung

Yun Chung Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for production of alpha-amylase in recombinant
    Patent number: 7550281
    Abstract: Disclosed is a novel recombinant Bacillus bacterial strain constructed by genetic engineering which has high productivity of aipha-amylase. The Bacillus strain comprises an alpha-amylase gene inserted in the Bacillus chromosome under transcriptional control of a phage promoter. An efficient process for the rapid production of large amounts of alpha-amylase is also disclosed.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: June 23, 2009
    Assignee: The Hong Kong Polytechnic University
    Inventors: Yun Chung Leung, Wai Hung Lo, Jeffery Errington
  • PHARMACEUTICAL PREPARATION AND METHOD OF TREATMENT OF HUMAN MALIGNANCIES WITH ARGININE DEPRIVATION
    Publication number: 20090123450
    Abstract: The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in a patient. The present invention also provides a pharmaceutical composition comprising the modified invention enzyme and method for treatment of diseases using the pharmaceutical composition.
    Type: Application
    Filed: July 24, 2008
    Publication date: May 14, 2009
    Inventors: Ning Man Cheng, Yun Chung Leung, Wai Hung Lo
  • Use of Arginase in Combination with 5FU and Other Compounds for Treatment of Human Malignancies
    Publication number: 20080292609
    Abstract: The present invention provides a method for treating cancer in a human patient by reducing the physiological arginine levels to below 10 ?M in combination with administering an anti-neoplastic compound. The present invention also provides a pharmaceutical composition comprising an arginine reducing compound, such as pegylated human arginase I, and an anti-neoplastic compound, such as 5-fluorouracil, for the treatment of malignancies in a human patient.
    Type: Application
    Filed: May 21, 2007
    Publication date: November 27, 2008
    Inventors: Ning Man Cheng, Yun Chung Leung, Wai Hung Lo
  • PHARMACEUTICAL PREPARATION AND METHOD OF TREATMENT OF HUMAN MALIGNANCIES WITH ARGININE DEPRIVATION
    Publication number: 20080248018
    Abstract: The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in a patient. The present invention also provides a pharmaceutical composition comprising the modified invention enzyme and method for treatment of diseases using the pharmaceutical composition.
    Type: Application
    Filed: February 12, 2007
    Publication date: October 9, 2008
    Inventors: Ning Man Cheng, Yun Chung Leung, Wai Hung Lo
  • Pharmaceutical Preparation and Method of Treatment of Human Malignancies with Arginine Deprivation
    Publication number: 20080226617
    Abstract: The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in a patient. The present invention also provides a pharmaceutical composition comprising the modified invention enzyme and method for treatment of diseases using the pharmaceutical composition.
    Type: Application
    Filed: November 5, 2007
    Publication date: September 18, 2008
    Inventors: Ning Man Cheng, Yun Chung Leung, Wai Hung Lo
  • Modified ?-lactamases and uses thereof
    Patent number: 7323303
    Abstract: A tool that can screen bacteria for ?-lactamases against a panel of various antibiotics is desirable. A biosensor incorporating an indicator molecule into ?-lactamases may achieve this purpose, but it requires that the attached indicator molecule must not impair the binding affinity of the protein to a great extent to provide a higher sensitivity. A modified ?-lactamases with a residue on the ?-loop or outside the ?-loop but close to the active site of ?-lactamase being replaced by a reactive residue is developed in this invention.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: January 29, 2008
    Assignee: Hong Kong Polytechnic University
    Inventors: Kwok-Yin Wong, Thomas Yun-Chung Leung, Pak-Ho Chan
  • Method for production of alpha-amylase in recombinant bacillus
    Publication number: 20020187541
    Abstract: A novel recombinant Bacillus bacterial strain is constructed by genetic engineering which has high productivity of alpha-amylase. The Bacillus strain comprising an alpha-amylase gene inserted in the Bacillus chromosome under transcriptional control of a phage promoter. An efficient process for the rapid production of large amounts of alpha-amylase is also disclosed.
    Type: Application
    Filed: August 7, 2002
    Publication date: December 12, 2002
    Applicant: The Hong Kong Polytechnic University
    Inventors: Yun Chung Leung, Wai Hung Lo, Jeffery Errington