Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.

Abstract: In accordance with various embodiments, services gatekeeper systems and methods allow mapping and protecting communication services APIs with OAuth and group access to user information. Such a system can include a plurality of applications, executing on one or more application servers. The services gatekeeper is operable to define a group of members using a group URI, intercept requests for access to communication services APIs, obtain authorization from a group owner for access to a specified communication services API for each member of the group, and enable access to the specified communication services API of each member of the group in accordance with the scope authorized by the group owner.

Abstract: An anti-counterfeit film comprising an amphichroic pattern is prepared by (1) mixing a polymerizable liquid crystal material of chiral structure and a photoinitiator, blade-coating the mixture on a base film and then drying; (2) partially exposing the resulting material produced in step (1) using a positioned UV lamp, then drying and exposing in an UV radiation to obtain a desired film. The film prepared by the method has an amphichroic pattern which typically presents a red and green picture when being vertically observed, the original red and green respectively changes into green and blue when being observed at a certain incline angel. The anti-counterfeit film is characterized by obvious color change, easy identification, practicability and convenience, thus facilitating promotion and application.

Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: A folding canopy has a canopy top made of flexible sheet material; and a canopy frame. The canopy top is adapted to attach onto the canopy frame, and the canopy frame includes a number of members. A pair of left cross support bars have a first left cross support bar, and a second left cross support bar. The first left cross support bar is pivotally connected to the second left cross support bar. A pair of right cross support bars includes a first right cross support bar, and a second right cross support bar. The first right cross support bar is pivotally connected to the second right cross support bar.

Abstract: Disclosed are synthetic nanocarrier compositions that comprise B cell antigen for desired antibody production and an off-target response attenuating polymeric coating as well as related methods.

Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise polymers that comprise at least two immunomodulatory agent moieties.

Abstract: The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain.

Abstract: A sensitive liquid crystalline polymeric material suitable for the reflective hologram recording and the preparing method thereof are disclosed. The material includes a base film, a buffer layer coated on one side of the base film, a sensitive polymeric layer coated on the other side of the buffer layer and a protective layer coated on the surface of the sensitive polymeric layer.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of synthetic nanocarriers, or components thereof, and biologically active agents, such as immunomodulatory agents, antigens, anticancer agents or antiviral agents. The biologically active agents are released from the synthetic nanocarriers in the presence of a reducing agent or by reaction with a thiol.

Abstract: Provided herein are compounds and related composition and methods that may be used to raise an antibody response to nicotinic compounds, in some embodiments.

Abstract: This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human influenza A virus hemagglutinin.

Abstract: This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include polypeptides obtained or derived from human influenza A virus hemagglutinin.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human influenza A virus M2 protein.

Abstract: An anti-counterfeit film comprising an amphichroic pattern is prepared by (1) mixing a polymerizable liquid crystal material of chiral structure and a photoinitiator, blade-coating the mixture on a base film and then drying; (2) partially exposing the resulting material produced in step (1) using a positioned UV lamp, then drying and exposing in an UV radiation to obtain a desired film. The film prepared by the method has an amphichroic pattern which typically presents a red and green picture when being vertically observed, the original red and green respectively changes into green and blue when being observed at a certain incline angel. The anti-counterfeit film is characterized by obvious color change, easy identification, practicability and convenience, thus facilitating promotion and application.

Abstract: The present invention relates to a sheet enabling to form dynamic three-dimensional images and a device for preparing thereof. The sheet comprises a base layer (1), a transparent protective layer (2), a reflective layer (3), and pixel points (4) that can form images. The transparent protective layer (2) is disposed at one side of the base layer (1), the pixel points (4) are embedded in the transparent protective layer (2). The pixel points (4) consist of microlenses (401) tightly closed together. The reflective layer (3) is disposed downbently at a lower part of the microlenses (401), wherein picture-text is recorded in the reflective layer (3). There is an altitude difference H between horizontal positions of two adjacent pixel points (4). Microlenses (401) in any one of pixel point have the same curvature radius, and curvature radius of microlenses (401) in two adjacent pixel points (4) have a difference of 1 to 70 ?m.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.