Abstract: Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.

Abstract: A portable electronic device includes a battery, a transcutaneous electrical nerve stimulation (TENS) circuit, a power management circuit, a first output unit, and a second output unit. The TENS circuit provides a TENS electrical current. The power management circuit is coupled to the battery and the TENS circuit for managing a power distribution of the portable electronic device. The first output unit receives the TENS electrical current from the TENS circuit and outputs the TENS electrical current to a user. The second output unit receives a power signal from the battery and outputs the power signal to an external electronic device.

Abstract: A system and method is provided for operating a high-field magnetic resonance (MR) system includes performing a series of data acquisition modules without respiratory gating. Each data acquisition module is formed of a steady-state free precession pulse sequence. Performing the series of data acquisition modules includes varying at least one of an amplitude of an excitation pulse or a repetition time of the steady-state free precession pulse sequence between adjacent data acquisition modules in the series of data acquisition modules to acquire a series of MR data with random or pseudo-random imaging acquisition parameters. The series of MR data is compared to a dictionary of signal evolution profiles to determine a match between the series of MR data with at least one signal evolution profile in the dictionary indicating at least one quantitative parameter in the subject.

Abstract: The disclosure describes a method and device for signal processing. The method includes generating a signal time series associated with a terminal device based on time points for signal collection and intensities of signals collected at the time points collected from the terminal device by signal collection devices deployed in a spatial object; obtaining at least one segment of the signal time series by segmenting the signal time series according to a pre-generated segmenting interval; and determining, for the at least one segment, if a user of the terminal device is located in the spatial object during a continuous period of time included in the at least one segment. The disclosure may be used to statistically analyze user traffic in a spatial object and reduce resource consumption.

Abstract: Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.

Abstract: An organic silicon electroluminescent display device includes a protective layer, a transparent conductive layer, an organic silicon electroluminescent layer and a basic conductive layer, which are combined to prepare a flat flaky or continuous wire or matrix point electroluminescent device.

Abstract: Example apparatus and methods perform magnetic resonance fingerprinting (MRF) for arterial spin labeling (ASL) based parameter quantification. ASL with MRF produces a nuclear magnetic resonance signal time course from which simultaneous quantification of ASL perfusion-related parameters can be achieved. The parameters may include cerebral blood flow, transit time, T1, or other parameters. The quantification uses values from a dictionary of signal time courses that were generated or augmented using Bloch simulation, knowledge of the sequence, or previous observations. The dictionary may account for inflow or outflow of labeled spins and may model arterial input. An ASL-MRF pulse sequence may differ from conventional pulse sequences. For example, an ASL-MRF pulse sequence may include non-uniform control pulses, non-uniform label pulses, non-uniform post labeling delay time, non-uniform background suppression pulses, non-uniform acquisition repetition time, or non-uniform acquisition flip angle.

Abstract: A magnetic resonance fingerprinting (“MRF”) framework that implements simultaneous multislice acquisition techniques with a Hadamard RF-encoding to simultaneously acquire magnetic resonance data from multiple slices simultaneously is described. As one non-limiting example, magnetic resonance data can be simultaneously acquired from four different slices. In other embodiments, however, the Hadamard encoding can be condensed into one or two acquisitions, rather than four.

Abstract: The present disclosure provides systems and methods for magnetic resonance fingerprinting (MRF). The method including steps comprising acquiring a plurality of MRF signals from a plurality of excitation volumes within a subject, wherein at least two of the plurality of excitation volumes differ in location within the subject, and wherein each of the excitation volumes partially overlap to form an overlap volume. The method also includes comparing the plurality of MRF signals acquired from the overlap volume with a dictionary of signal evolutions, determining one or more physical parameters of the overlap volume within the subject, and generating a report at least indicating the one or more physical parameters of the overlap volume within the subject.

Abstract: A system and method for performing magnetic resonance fingerprinting (MRF) is provided that includes performing a pulse sequence that is sensitive to field inhomogeneities to acquire a series of signal evolutions form a region of interest (ROI) of the subject to form MRF data. The method also includes varying field inhomogeneities across the ROI to acquire the series of signal evolutions, comparing the MRF data with an MRF dictionary to determine at least one tissue property of the subject in the ROI, and producing at least one map of the at least one tissue property.

Abstract: A mutant-type uricase, PEG modified mutant-type uricase, and application thereof. The mutant-type uricase has a cysteine residue introduced by recombination, the cysteine residue is located at an inactive region of the uricase, and one or more PEGs are coupled to the mutant-type uricase. The resulting PEGylated mutant-type uricase has characteristics of a half-life extension, product uniformity, and stable enzyme activity. Therefore, the present invention has a wide future application range.

Abstract: The invention is an annular lift fan system for a VTOL type aircraft. In detail, the invention comprises an annular duct (16), a lift fan set (3), engines (6, 7), a central fuselage (1), and an outer wing (5). The lift fan set (3) is mounted in the annular duct (16) and powered by the engines (6, 7) incorporated in the outer wing (5). The annular duct is open for the lift fan set to provide high lift efficiency in VTOL and transition mode, and is closed off by shutters and louvers to provide aerodynamic lift and reduce drag in cruise mode.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating object detection predictions from a neural network. In some implementations, an input characterizing a first region of an environment is obtained. The input includes a projected laser image generated from a three-dimensional laser sensor reading of the first region, a camera image patch generated from a camera image of the first region, and a feature vector of features characterizing the first region. The input is processed using a high precision object detection neural network to generate a respective object score for each object category in a first set of one or more object categories. Each object score represents a respective likelihood that an object belonging to the object category is located in the first region of the environment.

Abstract: Magnetic resonance fingerprinting (MRF) with simultaneous multivolume acquisition (SMVA) is described. One example nuclear magnetic resonance (NMR) apparatus includes an NMR logic that repetitively and variably samples (k, t, E) spaces associated with different volumes (e.g., slices) in an object to simultaneously acquire sets of NMR signals that are associated with different points in the (k, t, E) spaces. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals and compares the NMR signal evolution to reference signal evolutions. Since different volumes are excited differently, resulting signal evolutions can be acquired simultaneously from the different volumes and NMR parameters may be simultaneously determined for the multiple volumes, which reduces acquisition time and parameter map creation time.

Abstract: A method of fabricating a ceramic turbine blade, the method includes selective melting on a powder bed in order to obtain a blade mold cavity in a mold, a ceramic-based suspension is provided, the suspension is introduced into the blade mold cavity, the suspension is subjected to a gelation step in the mold cavity in order to obtain a blade suitable for being extracted from the mold cavity, and the blade is extracted from the mold cavity.

Abstract: An organic silicon electroluminescent display device includes a protective layer, a transparent conductive layer, an organic silicon electroluminescent layer and a basic conductive layer, which are combined to prepare a flat flaky or continuous wire or matrix point electroluminescent device.

Abstract: The disclosure describes a method and device for signal processing. The method includes generating a signal time series associated with a terminal device based on time points for signal collection and intensities of signals collected at the time points collected from the terminal device by signal collection devices deployed in a spatial object; obtaining at least one segment of the signal time series by segmenting the signal time series according to a pre-generated segmenting interval; and determining, for the at least one segment, if a user of the terminal device is located in the spatial object during a continuous period of time included in the at least one segment. The disclosure may be used to statistically analyze user traffic in a spatial object and reduce resource consumption.

Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

Abstract: Provided is a modular construction of synthetic gene circuits in mammalian cells using TALE transcriptional repressors.

Abstract: Apparatus, methods, and other embodiments associated with optimizing sounds produced during nuclear magnetic resonance (NMR) fingerprinting are described. One example NMR apparatus includes an NMR logic to repetitively and variably sample a (k, t, E) space associated with a patient to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The parameters are varied in different acquisition blocks to facilitate matching sounds produced in response to the acquisition blocks to a desired set of sounds. The desired set of sounds may be a musical piece.