Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: The present invention is a pharmaceutical or food composition comprising a pretreated extract and an isolate and an isolated and purified product of Cinnamomum cassia showing a pharmacological effect. It relates to an active ingredient showing physiological activity in the Cinnamomum cassia extract.

Abstract: A multilayer electronic component includes a body including a dielectric layer and an internal electrode; and an external electrode disposed on the body, wherein the dielectric layer includes a plurality of dielectric grains, and wherein the plurality of dielectric grains include one or more first dielectric grains in which a sum of lengths of defects in a dielectric grain is 150 nm or more.

Abstract: A manufacturing method of a dielectric ceramic composition includes attaching a reactive functional group to a surface of a base material powder particle of a perovskite structure.

Abstract: A method of producing a core-shell particle includes introducing a barium titanate-based base powder and an additive to a reactor, and exposing the barium titanate-based base powder and the additive to a thermal plasma torch to obtain core-shell particles including a core portion having barium titanate (BaTiO3) and a shell portion including the additive and formed on a surface of the core portion.

Abstract: A method of producing a core-shell particle includes introducing a barium titanate-based base powder and an additive to a reactor, and exposing the barium titanate-based base powder and the additive to a thermal plasma torch to obtain core-shell particles including a core portion having barium titanate (BaTiO3) and a shell portion including the additive and formed on a surface of the core portion.

Abstract: A manufacturing method of a dielectric ceramic composition includes attaching a reactive functional group to a surface of a base material powder particle of a perovskite structure.

Abstract: A method of producing a core-shell particle includes introducing a barium titanate-based base powder and an additive to a reactor, and exposing the barium titanate-based base powder and the additive to a thermal plasma torch to obtain core-shell particles including a core portion having barium titanate (BaTiO3) and a shell portion including the additive and formed on a surface of the core portion.

Abstract: Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPAR? and PPAR? activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Abstract: A dielectric material includes a barium titanate based base material main ingredient and an accessory ingredient. In a fine sintered structure of the dielectric material, crystal grains in which a content of Ca is less than 2.5 mol % are first crystal grains, crystal grains in which the content of Ca is 4.0 to 12.0 mol % are second crystal grains, and a ratio of an average size of the first crystal grains to an average size of the second crystal grains is in a range of 1.6 to 2.2.

Abstract: Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPAR? and PPAR? activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Abstract: There is provided a dielectric ceramic composition including a base powder, wherein the base powder includes: a first major component represented by BaTiO3, a second major component represented by (Na, K)NbO3, and a third major component represented by (Bi, Na)TiO3. The base powder is represented by xBaTiO3-y(Na, K)NbO3-z(Bi, Na)TiO3, where x+y+z=1, and x, y, and z are represented by mol, and x, y and z satisfy 0.5?x?0.97, 0.01?y?0.48, and 0.02?z?0.2, respectively. In certain embodiments, the base powder is be represented by xBaTiO3-y(Na0.5K0.5)NbO3-z(Bi0.5Na0.5)TiO3.

Abstract: A dielectric material includes a barium titanate based base material main ingredient and an accessory ingredient. In a fine sintered structure of the dielectric material, crystal grains in which a content of Ca is less than 2.5 mol % are first crystal grains, crystal grains in which the content of Ca is 4.0 to 12.0 mol % are second crystal grains, and a ratio of an average size of the first crystal grains to an average size of the second crystal grains is in a range of 1.6 to 2.2.

Abstract: The present invention relates to a novel endocytic motif, and in particular, to a fusion polypeptide including the motif represented by an amino acid sequence of SEQ ID NO. 1 and a protein transduction domain, a pharmaceutical composition for preventing or treating cancer including the same, and a method for treating cancer including the step of administering the composition. The present invention shows the effects of suppressing metastasis, infiltration, angiogenesis, and growth of cancer by specifically inhibiting c-Met endocytosis and effectively inhibiting HGF/c-Met signaling pathway associated with metastasis and growth of various types of cancer cells. Therefore, the present invention can be applied to an anticancer agent for various types of cancer.

Abstract: A dielectric ceramic composition includes a main component comprising (1-x)BaTiO3-x(Na1-yKy)NbO3, where 0.005?x?0.5 and 0.3?y?1.0; a first subcomponent comprising an element selected from the group consisting of Mn, V, Cr, Fe, Ni, Co, Cu and Zn; and a second subcomponent comprising SiO2.

Abstract: There is provided a dielectric ceramic composition including: a major component (a barium titanate-based base material); and a minor component, wherein the dielectric ceramic composition is sintered to form a sintered body having a fine structure, the fine structure includes first crystal grains in which a Ca content is lower than 2.5 mol % and second crystal grains in which a Ca content is between 2.5 mol % to 13.5 mol %, and the second crystal grains have a cross-sectional area ratio of 30% to 80% on the basis of 100% of an overall cross-sectional area of the fine structure.

Abstract: A dielectric ceramic composition contains a base material main ingredient and an accessory ingredient. The base material main ingredient includes a first base material main ingredient containing BaTiO3 and a second base material main ingredient containing (Na1-yKy)NbO3. The base material main ingredient is represented by (1?x)BaTiO3-x(Na1-yKy)NbO3, in which x and y satisfy 0.005?x?0.5 and 0.3?y?1.0, respectively.

Abstract: There are provided a dielectric ceramic composition and a multilayer ceramic capacitor containing the same. The dielectric ceramic composition may contain a base material powder represented by (Ca1-xSrx)(Zr1-yTiy)O3 (0?x?1.0 and 0.3?y?0.8). A multilayer ceramic capacitor may include a ceramic body in which dielectric layers and first and second internal electrodes are alternately stacked, wherein the dielectric layers contain a dielectric ceramic composition containing a base material powder represented by (Ca1-xSrx)(Zr1-yTiy)O3 (0?x?1.0 and 0.3?y?0.8).

Abstract: Disclosed is a method for manufacturing a lithium transition metal phosphate. The disclosed method for manufacturing a lithium transition metal phosphate comprises the steps of: injecting reaction materials containing lithium, a transition metal, and a phosphate, into a reactor, and mixing the raw materials at the molecular level in the reactor; and allowing the reaction materials to chemically react in the reactor so as to cause nucleation.

Abstract: There is provided a dielectric ceramic composition including: a major component (a barium titanate-based base material); and a minor component, wherein in an XRD analysis of a sintered body obtained by sintering the dielectric ceramic composition, when a (110) peak of BaTiO3 is set as 1.00, a ratio of a peak of pyrochlore (RE2Ti2O7) at about 30.5 degrees with respect to the (110) peak of BaTiO3 satisfies 0.02 or less, where RE is at least one of Y, Dy, Ho, Sm, Gd, Er, La, Ce, Nd, Tb, and Pr.