Patents by Inventor Yun Rose Li

Yun Rose Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for use in the diagnosis of autoimmune diseases
    Patent number: 11718877
    Abstract: This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared. The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols for patients with one or more autoimmune diseases based on determining if the patients have genetic alterations in particular genes.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: August 8, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Yun Rose Li, Brendan Keating
  • COMPOSITIONS AND METHODS FOR USE IN COMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES
    Publication number: 20200080152
    Abstract: This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared. The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols for patients with one or more autoimmune diseases based on determining if the patients have genetic alterations in particular genes.
    Type: Application
    Filed: August 20, 2019
    Publication date: March 12, 2020
    Inventors: Hakon Hakonarson, Yun Rose Li, Brendan Keating
  • Methods of treating autoimmune conditions in patients with genetic variations in DcR3 or in a DcR3 network gene
    Patent number: 10407725
    Abstract: The present disclosure relates to methods of treating autoimmune conditions in patients who have genetic alterations in the TNFRSF6B gene, which codes for the decoy receptor 3 protein (DcR3), for example that reduce the expression, secretion, or ligand binding activity of DcR3. For example, in some embodiments, the conditions may be treated with molecules that inhibit the activity of DcR3 ligands such as LIGHT, TL1A, and FasL, such as anti-LIGHT, anti-TL1A, and anti-FasL antibodies, or inhibitors of the non-canonical NF-?B pathway.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: September 10, 2019
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao, Christopher Cardinale, Rahul Pandey, Yun Rose Li
  • Methods for use in combination for the treatment and diagnosis of autoimmune diseases
    Patent number: 10385398
    Abstract: This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared. The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols for patients with one or more autoimmune diseases based on determining if the patients have genetic alterations in particular genes.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: August 20, 2019
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Yun Rose Li, Brendan Keating
  • Methods of Treating Autoimmune Conditions in Patients with Genetic Variations in DCR3 or in a DCR3 Network Gene
    Publication number: 20170051352
    Abstract: The present disclosure relates to methods of treating autoimmune conditions in patients who have genetic alterations in the TNFRSF6B gene, which codes for the decoy receptor 3 protein (DcR3), for example that reduce the expression, secretion, or ligand binding activity of DcR3. For example, in some embodiments, the conditions may be treated with molecules that inhibit the activity of DcR3 ligands such as LIGHT, TL1A, and FasL, such as anti-LIGHT, anti-TL1A, and anti-FasL antibodies, or inhibitors of the non-canonical NF-?B pathway.
    Type: Application
    Filed: August 19, 2016
    Publication date: February 23, 2017
    Inventors: Hakon Hakonarson, Charlly Kao, Christopher Cardinale, Rahul Pandey, Yun Rose Li
  • Compositions and Methods for Use in Combination for the Treatment and Diagnosis of Autoimmune Diseases
    Publication number: 20170051351
    Abstract: This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared. The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols for patients with one or more autoimmune diseases based on determining if the patients have genetic alterations in particular genes.
    Type: Application
    Filed: August 19, 2016
    Publication date: February 23, 2017
    Inventors: Hakon Hakonarson, Yun Rose Li, Brendan Keating