Patents by Inventor Yun-Xing Wang

Yun-Xing Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds that bind to human immunodeficiency virus rev response element
    Patent number: 11692010
    Abstract: Compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA are provided. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also provided are methods of treating or inhibiting HIV including administering one or more of the RRE binding compounds to a subject.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: July 4, 2023
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Yun-Xing Wang, Ping Yu
  • Method for synthesizing selectively labeled RNA
    Patent number: 11041182
    Abstract: The invention relates to a method for synthesizing a selectively labeled RNA, and an apparatus for performing the method. Specific segments or discrete residues within the RNA may be selectively labeled, and different segments may include different labels.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: June 22, 2021
    Assignees: The Government of the United States of America, The Board of Regents of the University of Texas System
    Inventors: Yun-Xing Wang, Yu Liu, Rui Sousa
  • COMPOUNDS THAT BIND TO HUMAN IMMUNODEFICIENCY VIRUS REV RESPONSE ELEMENT
    Publication number: 20200048310
    Abstract: Disclosed herein are compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also disclosed are methods of treating or inhibiting HIV including administering one or more of the disclosed compounds to a subject.
    Type: Application
    Filed: October 25, 2019
    Publication date: February 13, 2020
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Yun-Xing Wang, Ping Yu
  • Compounds that bind to human immunodeficiency virus rev response element
    Patent number: 10464970
    Abstract: Compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA are provided. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also provided are methods of treating or inhibiting HIV including administering one or more of the RRE binding compounds to a subject.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: November 5, 2019
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Yun-Xing Wang, Ping Yu
  • METHOD FOR SYNTHESIZING SELECTIVELY LABELED RNA
    Publication number: 20190241920
    Abstract: The invention relates to a method for synthesizing a selectively labeled RNA, and an apparatus for performing the method. Specific segments or discrete residues within the RNA may be selectively labeled, and different segments may include different labels.
    Type: Application
    Filed: January 25, 2019
    Publication date: August 8, 2019
    Inventors: Yun-Xing Wang, Yu Liu, Rui Sousa
  • Method for synthesizing selectively labeled RNA
    Patent number: 10190143
    Abstract: The invention relates to a method for synthesizing a selectively labeled RNA, and an apparatus for performing the method. Specific segments or discrete residues within the RNA may be selectively labeled, and different segments may include different labels.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: January 29, 2019
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH
    Inventors: Yun-Xing Wang, Yu Liu, Rui Sousa
  • COMPOUNDS THAT BIND TO HUMAN IMMUNODEFICIENCY VIRUS REV RESPONSE ELEMENT
    Publication number: 20160237121
    Abstract: Disclosed herein are compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also disclosed are methods of treating or inhibiting HIV including administering one or more of the disclosed compounds to a subject.
    Type: Application
    Filed: October 23, 2014
    Publication date: August 18, 2016
    Applicant: The United States of America, as represented by th e Secretary, Dept. of Health and Human Services
    Inventors: Yun-Xing Wang, Ping Yu
  • METHOD FOR SYNTHESIZING SELECTIVELY LABELED RNA
    Publication number: 20160160256
    Abstract: The invention relates to a method for synthesizing a selectively labeled RNA, and an apparatus for performing the method. Specific segments or discrete residues within the RNA may be selectively labeled, and different segments may include different labels.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 9, 2016
    Inventors: Yun-Xing Wang, Yu Liu, Rui Sousa