Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: The present invention relates to a pad spring for a vehicle brake. To this end, according to an aspect of the present invention, there are provided pad springs for a vehicle brake which are installed in a pad carrier to apply elastic forces in directions in which a pad plate including a brake pad is spaced apart from a disc when an operation of a vehicle brake is released, wherein the pad carrier includes a leading side support frame, a trailing side support frame, an inner side support beam, and an outer side support beam, wherein the support beams connect the support frames, and the pad spring is provided on each of the inner side support beam and the outer side support beam, wherein at least one among a width, a length, and a thickness of a retraction bar provided on one of the pad springs is different from that provided on each of the remaining pad springs so that an elastic force is applied to the pad plate.

Abstract: The present invention relates to a pad spring for a vehicle brake. To this end, according to an aspect of the present invention, there are provided pad springs for a vehicle brake which are installed in a pad carrier to apply elastic forces in directions in which a pad plate including a brake pad is spaced apart from a disc when an operation of a vehicle brake is released, wherein the pad carrier includes a leading side support frame, a trailing side support frame, an inner side support beam, and an outer side support beam, wherein the support beams connect the support frames, and the pad spring is provided on each of the inner side support beam and the outer side support beam, wherein at least one among a width, a length, and a thickness of a retraction bar provided on one of the pad springs is different from that provided on each of the remaining pad springs so that an elastic force is applied to the pad plate.

Abstract: Disclosed herein is a disc brake for vehicle. The disc brake for vehicle according to the embodiment includes a pair of friction pads disposed at both sides of a disc, a caliper housing and a piston configured to press the pair of the friction pads against the disc, and a moving guide configured to guide movement of the pair of the friction pads pressed against the disc by the caliper housing and the piston, wherein the moving guide may include a pair of guide arms disposed at both outer sides of the caliper housing and integrally connected by a steering knuckle of a vehicle, and the friction pad may be slidably supported by the guide arms using a pair of outward protrusions provided at both sides of the friction pad such that the friction pad extends between the pair of the guide arms and the caliper housing and further include a pad clip assembled with the outward protrusion to provide elastic support between the outward protrusion and the caliper housing.

Abstract: Disclosed herein is a disc brake for vehicle. The disc brake for vehicle according to the embodiment includes a pair of friction pads disposed at both sides of a disc, a caliper housing and a piston configured to press the pair of the friction pads against the disc, and a moving guide configured to guide movement of the pair of the friction pads pressed against the disc by the caliper housing and the piston, wherein the moving guide may include a pair of guide arms disposed at both outer sides of the caliper housing and integrally connected by a steering knuckle of a vehicle, and the friction pad may be slidably supported by the guide arms using a pair of outward protrusions provided at both sides of the friction pad such that the friction pad extends between the pair of the guide arms and the caliper housing and further include a pad clip assembled with the outward protrusion to provide elastic support between the outward protrusion and the caliper housing.