Abstract: An objective of the present invention is to provide a method and apparatus for operating a screen of a touch screen device. If a first input operation information of a user matches the input operation information preset for launching a single-handed mode, divide the screen into N (N>1) main zones according to preset configuration information, wherein one main zone is an operating zone, the operating zone being divided into N sub-zones, and the N main zones having a one-to-one correspondence to the N sub-zones; obtain a second input operation information of a user with respect to the operating zone, the second input operation information being for operating a sub-zone therein; determine a main zone corresponding to the sub-zone; and exchange positions of the determined main zone and the operating zone. By using the present invention, the user may perform single-handed operations of all contents within the touch screen, and meanwhile various advantages of a large touch screen are maintained.