Patents by Inventor YunFeng Fang

YunFeng Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-membered heterocycle-based p38 kinase inhibitors
    Patent number: 8580838
    Abstract: Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38?, and p38? kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: November 12, 2013
    Assignee: Novartis AG
    Inventors: Hengyuan Lang, Olga M. Fryszman, Edcon Chang, Jiong Lan, Yunfeng Fang
  • 5-membered heterocycle-based P38 kinase inhibitors
    Patent number: 8410160
    Abstract: Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38?, and p38? kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: April 2, 2013
    Assignee: Novartis AG
    Inventors: Olga M. Fryszman, Hengyuan Lang, Jiong Lan, Edcon Chang, Yunfeng Fang
  • 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS
    Publication number: 20120264801
    Abstract: Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38?, and p38? kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
    Type: Application
    Filed: June 22, 2012
    Publication date: October 18, 2012
    Applicant: NOVARTIS AG
    Inventors: Olga M. FRYSZMAN, Hengyuan LANG, Jiong LAN, Edcon CHANG, Yunfeng FANG
  • 5-membered heterocycle-based p38 kinase inhibitors
    Patent number: 8242117
    Abstract: Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38? and p38? kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: August 14, 2012
    Assignee: Novartis AG
    Inventors: Olga M. Fryszman, Hengyuan Lang, Jiong Lan, Edcon Chang, Yunfeng Fang
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Patent number: 8093265
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 10, 2012
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl Compounds As P2X7 Modulators and Uses Thereof
    Publication number: 20110118287
    Abstract: Bicycloheteroaryl compounds are disclosed that have formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: May 19, 2011
    Applicant: RENOVIS, INC.
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, Yeyu Cao, Carl Kaub, Sumithra Gowlugari
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Publication number: 20110092476
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: October 18, 2010
    Publication date: April 21, 2011
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS
    Publication number: 20110071152
    Abstract: Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38? and p38? kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
    Type: Application
    Filed: November 19, 2010
    Publication date: March 24, 2011
    Inventors: Olga M. FRYSZMAN, Hengyuan LANG, Jiong LAN, Edcon CHANG, Yunfeng FANG
  • 5-membered heterocycle-based p38 kinase inhibitors
    Patent number: 7863314
    Abstract: Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38? and p38? kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: January 4, 2011
    Assignee: Novartis AG
    Inventors: Olga M. Fryszman, Hengyuan Lang, Jiong Lan, Edcon Chang, Yunfeng Fang
  • Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
    Publication number: 20100298285
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: November 25, 2010
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
    Publication number: 20100292235
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: November 18, 2010
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl compounds as P2Xmodulators and uses thereof
    Patent number: 7816371
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 19, 2010
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, legal representative, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
    Publication number: 20100184802
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: July 22, 2010
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Benzamide derivatives as p-38 kinase inhibitors
    Patent number: 7754726
    Abstract: Benzamide combounds of Formula I: and their compositions for modulating the activity of p38 kinases are provided, including p38?, and p38? kinase. Methods for treating, preventing or ameliorating one or more symptoms of a p38 kinase mediated disease or disorder such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases are also provided.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: July 13, 2010
    Assignee: Novartis AG
    Inventors: Hengyuan Lang, Jiong Lan, Yunfeng Fang
  • p-38 kinase inhibitors
    Patent number: 7700622
    Abstract: Compounds and compositions for modulating the activity of p38 kinases are provided, including p38? and p38? kinase. Methods for treating, preventing or ameliorating one or more symptoms of a p38 kinase mediated disease or disorder are also provided.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: April 20, 2010
    Assignee: Novartis AG
    Inventors: Hengyuan Lang, Jiong Lan, Yunfeng Fang
  • Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
    Publication number: 20100004222
    Abstract: Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 22, 2007
    Publication date: January 7, 2010
    Applicant: Renovis, Inc.
    Inventors: Michael G. Kelly, Carl J. Kaub, John Kincaid, Satyanarayana Janagani, Guoxian Wu, Zhi-Liang Wei, Kiran Sahasrabudhe, Matthew Duncton, Ravindra B. Upasani, Yunfeng Fang, Matthew Cox, Jianhua He
  • Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
    Publication number: 20090298825
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: December 3, 2009
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
    Patent number: 7576099
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: August 18, 2009
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra B. Upasani, Guoxian Wu, Jianhua He, legal representative, Zhi-Liang Wei, Carl Kaub, YunFeng Fang
  • Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
    Publication number: 20080300243
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 24, 2006
    Publication date: December 4, 2008
    Inventors: Michael G. Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra B. Upasani, Guoxian Wu, YunFeng Fang, Zhi-Liang Wei, Carl Kaub, Jianhua He
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Publication number: 20080287415
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 7, 2008
    Publication date: November 20, 2008
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang