Abstract: Various techniques are provided to reduce common mode disturbance associated with an amplifier, such as a class D amplifier. In one example, an amplifier includes a power stage configured to generate first and second PWM signals. The amplifier further includes an integration stage comprising input nodes configured to receive an input differential analog signal. The integration stage is configured to generate an output differential analog signal in response to the PWM signals and the input differential analog signal. The amplifier further includes an active compensation circuit configured to provide a compensation signal to the integration stage to reduce disturbances at the input nodes associated with the PWM signals switching between a common mode and a differential mode. Additional devices, systems, and methods are also provided.

Abstract: Various techniques are provided to reduce common mode disturbance associated with an amplifier, such as a class D amplifier. In one example, an amplifier includes a power stage configured to generate first and second PWM signals. The amplifier further includes an integration stage comprising input nodes configured to receive an input differential analog signal. The integration stage is configured to generate an output differential analog signal in response to the PWM signals and the input differential analog signal. The amplifier further includes an active compensation circuit configured to provide a compensation signal to the integration stage to reduce disturbances at the input nodes associated with the PWM signals switching between a common mode and a differential mode. Additional devices, systems, and methods are also provided.

Abstract: Systems and methods include a circuit having a plurality of integrator circuits arranged in series and configured to receive an input signal at a first of the plurality of integrators and generate an output signal at a last of the plurality of integrators, a filter arranged to receive a feedback signal comprising the output signal and generate a filtered feedback signal, which is applied to the input signal before input to the first of the plurality of integrators, and a feedback signal path configured to receive the feedback signal and apply the feedback signal to an input of a second of the plurality of integrators. The circuit may include a class-D amplifier and/or a delta-sigma modulator. The input signal may include an analog audio signal that is amplifier to drive an audio speaker.

Abstract: Systems and methods include a circuit having a plurality of integrator circuits arranged in series and configured to receive an input signal at a first of the plurality of integrators and generate an output signal at a last of the plurality of integrators, a filter arranged to receive a feedback signal comprising the output signal and generate a filtered feedback signal, which is applied to the input signal before input to the first of the plurality of integrators, and a feedback signal path configured to receive the feedback signal and apply the feedback signal to an input of a second of the plurality of integrators. The circuit may include a class-D amplifier and/or a delta-sigma modulator. The input signal may include an analog audio signal that is amplifier to drive an audio speaker.

Abstract: An assay kit for in-situ hybridization (Rho GDP dissociation inhibitor beta, ISH) of RhoGDI2 gene, an assay method therefor and a use of the assay kit are provided. The assay kit includes: a hybridization probe, a marker, a hybridization solution, and an enhancement reagent. The hybridization probe has a sequence of SEQ ID NO. 1. The assay method includes steps of: (a) mixing the hybridization probe of the assay kit with a to-be-tested RNA on a substrate to form a hybridization complex; and (b) assaying the hybridization complex formed in the step (a). The use of the assay kit is applied the assay kit to prepare a therapeutic medicines for early metastasis of a carcinoma or a relapse disease. The assay kit of the present invention can enhance sensitivity and strengthen specificity. Meanwhile, the assay method of the present invention can increase operational convenience and simplify procedures, so that the assay method can be popularized in the medical institutions including local hospitals.