Abstract: Provided are sustained-release pharmaceutical compositions including a ketamine pamoate salt and a pharmaceutically acceptable carrier thereof. The compositions include aqueous suspension, solution and matrix delivery system, which can provide sustained release for anesthesia, analgesia or treatment of central nervous system and anti-inflammatory diseases.

Abstract: A pad (30) for the protection and support of the Achilles tendon of the foot is provided for an over-the-ankle shoe (10). The pad (30) is formed of resiliently yieldable material and is disposed between the exterior upper (26) of the shoe and an interior linear (28). The pad (30) extends vertically from the top (38) of the shoe downward sufficiently to cover the most exteriorly prominent section of the Achilles tendon, and extends horizontally at least far enough to protect the Achilles tendon from strain or injury, while allowing for flexure of same.

Abstract: An athletic shoe (10) comprises an outsole (12) and an upper (14) secured thereto and cooperating therewith to enclose the foot of the wearer. Upper (14) is of a one-piece full slip-on construction and is designed to overlay the dorsal and ventral surfaces of the foot and thus completely enclose the foot of the wearer. Outsole (12) comprises an upper layer (16) for being disposed adjacent the bottom surface of upper (14) and a lower layer (18) secured thereto for being disposed adjacent the ground. Upper layer (16) overlays lower layer (18) and includes side portions (20) which extend upwardly to overlap upper (14) and to be secured thereto. The upper surface of upper layer (16) includes a bridge (22) consisting of a plurality of diamond-shaped recesses extending laterally across the width of the shoe and rearwardly from a point proximate the instep of the foot to the heel of the foot.