Patents by Inventor Yungen Xu

Yungen Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20240059694
    Abstract: The invention provides a compound containing a 1,3-benzodioxol structure and a preparation method and use thereof. The invention discloses a 1,3-benzodioxol derivative as shown in general formula (1). Results of pharmacological experiments indicate that compound (I) of the invention can exert excellent inhibition on both BTK and JAK3 kinases, and can be used to prepare medicines for treating rheumatoid arthritis caused by over-activation of BTK and/or JAK3 pathways. The invention further discloses a preparation method for the 1,3-benzodioxol derivative.
    Type: Application
    Filed: March 24, 2022
    Publication date: February 22, 2024
    Applicant: XI'AN XINTONG PHARMACEUTICAL RESEARCH CO., LTD.
    Inventors: Yungen XU, Tingting LIANG, Qihua ZHU, Junjie WANG, Lifang CEN, Wenjie WANG, Jiaming JIN
  • NOVEL BIPHENYL DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
    Publication number: 20240043392
    Abstract: The invention relates to the field of medicinal chemistry, and discloses a class of biphenyl derivatives with PD-1/PD-L1 inhibitory activity, and a preparation method and use thereof. The invention further discloses a composition containing the biphenyl derivatives with PD-1/PD-L1 inhibitory activity or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier, and applications of the composition in preparation of PD-1/PD-L1 inhibitors. The compounds of the invention are useful in the therapy used to treat tumors.
    Type: Application
    Filed: April 22, 2022
    Publication date: February 8, 2024
    Applicant: XI'AN XINTON PHARMACEUTCAL RESEARCH CO., LTD.
    Inventors: Yungen XU, Hongbo ZHANG, Qihua ZHU, Huijie DU, Yu XIA, Chunqiu YU, Shihui HUANG, Hui LI, Yi ZOU
  • PARP/PI3K double-target inhibit containing pyridopyrimidine structure
    Patent number: 11572359
    Abstract: The present disclosure relates to the field of pharmaceutical chemistry, in particular to a class of PARP/PI3K double-target inhibitors (I) containing structures of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine and phthalazin-1(2H)-one and a preparation method thereof. As proved by pharmacodynamic tests, the compounds of the present disclosure have PARP/PI3K double-target inhibitory activity and can be used for anti-tumor.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: February 7, 2023
    Assignee: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Yungen Xu, Qihua Zhu, Junwei Wang, Hui Li, Zhaoxing Chu, Guangwei He
  • PARP/PI3K DOUBLE-TARGET INHIBITOR CONTAINING PYRIDOPYRIMIDINE STRUCTURE
    Publication number: 20210179610
    Abstract: The present disclosure relates to the field of pharmaceutical chemistry, in particular to a class of PARP/PI3K double-target inhibitors (I) containing structures of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine and phthalazin-1(2H)-one and a preparation method thereof. As proved by pharmacodynamic tests, the compounds of the present disclosure have PARP/PI3K double-target inhibitory activity and can be used for anti-tumor.
    Type: Application
    Filed: August 1, 2018
    Publication date: June 17, 2021
    Inventors: Yungen XU, Qihua ZHU, Junwei WANG, Hui LI, Zhaoxing CHU, Guangwei HE
  • Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof
    Patent number: 7820692
    Abstract: A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as ?-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: October 26, 2010
    Assignees: China Pharmaceutical University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Yangtze River Pharmaceutical Group Co., Ltd.
    Inventors: Yungen Xu, Jinggen Liu, Ting Guo, Dechuan Wang, Tianjiang Sun, Hongguo Lu
  • Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof
    Publication number: 20090275607
    Abstract: A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as ?-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.
    Type: Application
    Filed: July 10, 2007
    Publication date: November 5, 2009
    Inventors: Yungen Xu, Jinggen Liu, Ting Guo, Dechuan Wang, Tianjiang Sun, Hongguo Lu
  • Conversion process for 2,3-benzodiazepine enantiomers
    Patent number: 7541355
    Abstract: Methods for the racemization of an enantiomer of a 2,3-benzodiazepine molecule into the corresponding racemic mixture under either basic or acidic conditions are described. Furthermore, the invention relates to the conversion of an enantiomer of tofisopam or its metabolites to the corresponding opposite enantiomer.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: June 2, 2009
    Assignee: Vela Acquisition Corporation
    Inventors: Yong Victoria Wei, Naidaong Ye, Kimm Galbraith, Jianfeng Shi, Wuyi Wang, Yungen Xu, Mallikarjun Reddy Ravi
  • Conversion process for 2,3-benzodiazepine enantiomers
    Publication number: 20060264421
    Abstract: Methods for the racemization of an enantiomer of a 2,3-benzodiazepine molecule into the corresponding racemic mixture under either basic or acidic conditions are described. Furthermore, the invention relates to the conversion of an enantiomer of tofisopam or its metabolites to the corresponding opposite enantiomer.
    Type: Application
    Filed: May 23, 2005
    Publication date: November 23, 2006
    Applicant: Vela Pharmaceuticals, Inc.
    Inventors: Yong Wei, Naidong Ye, Kimm Galbraith, Jianfeng Shi, Wuyi Wang, Yungen Xu, Mallikarjun Ravi