Patents by Inventor Yunhang Guo

Yunhang Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1,5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES
    Publication number: 20200024273
    Abstract: Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Application
    Filed: September 23, 2017
    Publication date: January 23, 2020
    Inventors: Hexiang Wang, Yunhang Guo, Bo Ren, Zhiwei Wang, Guoliang Zhang, Changyou Zhou
  • NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES
    Publication number: 20190284184
    Abstract: Disclosed herein are 5 or 8-substituted imidazo[1,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[1,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo[1,5-a]pyridines that can be useful for inhibiting indoleamine 2,3-dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Application
    Filed: March 27, 2019
    Publication date: September 19, 2019
    Inventors: Hexiang Wang, Guoliang Zhang, Yunhang Guo, Bo Ren, Zhiwei Wang, Changyou Zhou
  • CRYSTALLINE FORM OF (S)-7-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRA-HYDROPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE, PREPARATION, AND USES THEREOF
    Publication number: 20190169201
    Abstract: The present invention relates to a crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetr a-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide for inhibiting Btk, methods of preparation thereof and pharmaceutical compositions, and use of the crystalline form above in the treatment of a disease, or in the manufacturing of a medicament for the treatment of a disease.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 6, 2019
    Inventors: Zhiwei Wang, Yunhang Guo, Gongyin Shi
  • 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases
    Patent number: 10280163
    Abstract: Disclosed herein are 5 or 8-substituted imidazo[1,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[1,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo[1,5-a]pyridines that can be useful for inhibiting indoleamine 2,3-dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: May 7, 2019
    Assignee: BEIGENE, LTD.
    Inventors: Hexiang Wang, Guoliang Zhang, Yunhang Guo, Bo Ren, Zhiwei Wang, Changyou Zhou
  • SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS
    Publication number: 20180251466
    Abstract: The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Application
    Filed: May 3, 2018
    Publication date: September 6, 2018
    Applicant: BeiGene, Ltd.
    Inventors: Zhiwei WANG, Yunhang GUO
  • Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
    Patent number: 10005782
    Abstract: The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: June 26, 2018
    Assignee: BEIGENE, LTD.
    Inventors: Zhiwei Wang, Yunhang Guo
  • NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES
    Publication number: 20180072716
    Abstract: Disclosed herein are 5 or 8-substituted imidazo[1,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[1,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo[1,5-a]pyridines that can be useful for inhibiting indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 15, 2018
    Inventors: Hexiang WANG, Gouliang ZHANG, Yunhang GUO, Bo REN, Zhiwei WANG, Changyou ZHOU
  • FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
    Publication number: 20170073349
    Abstract: The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Applicant: BeiGene, Ltd.
    Inventors: Zhiwei WANG, Yunhang GUO
  • Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulators
    Patent number: 9556188
    Abstract: The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: January 31, 2017
    Assignee: BeiGene, Ltd.
    Inventors: Zhiwei Wang, Yunhang Guo
  • Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
    Patent number: 9447106
    Abstract: The invention is substituted 4,5-dihydro- and 4,5,6,7-tetrahydro-pyrazolo[1,5-?]pyrimidine compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor, such as inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: September 20, 2016
    Assignee: BeiGene, Ltd.
    Inventors: Zhiwei Wang, Yunhang Guo
  • Fused heterocyclic compounds as protein kinase inhibitors
    Publication number: 20160083392
    Abstract: The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Application
    Filed: November 25, 2015
    Publication date: March 24, 2016
    Applicant: Beigene, Ltd.
    Inventors: Zhiwei Wang, Yunhang Guo
  • Fused heterocyclic compounds as protein kinase inhibitors
    Publication number: 20150259354
    Abstract: The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Application
    Filed: May 27, 2015
    Publication date: September 17, 2015
    Applicant: Beigene, Ltd.
    Inventors: Zhiwei Wang, Yunhang Guo
  • Protein Kinase Inhibitors and Uses Thereof
    Publication number: 20150005277
    Abstract: The invention is compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.
    Type: Application
    Filed: June 21, 2014
    Publication date: January 1, 2015
    Inventors: Zhiwei Wang, Yunhang Guo