Abstract: A mixing device includes: a box body including a box bottom and an enclosure wall, the box bottom and the enclosure wall forming an accommodating cavity for holding liquid; a sealing strip, detachably joined to the enclosure wall to form a liquid conveying channel along a vertical direction between the enclosure wall and the sealing strip; and a Venturi structure separably disposed on a side of the box body. The liquid conveying channel is formed by joining the sealing strip to the box body, which solves a problem in that a traditional milk pipe is not easily cleaned, and a design without a milk pipe is combined with the complete Venturi structure, which ensures quality of the made milk foam, thereby meeting requirements of people for pursuing delicate mouthfeel and improving taste.

Abstract: Provided is a kit for calibration of an isothermal polymerase chain reaction (PCR) analyzer and use thereof. The kit includes a standard substance, an amplification primer set, a reaction buffer, a polymerase, a dye, and a negative control. The standard substance is a DNA plasmid with a gradient concentration of 100 copies/?L to 106 copies/?L; the amplification primer set has nucleotide sequences shown in SEQ ID NO: 1 to SEQ ID NO: 6; the polymerase is a Bst DNA polymerase; and the dye is a loop-mediated isothermal amplification (LAMP) fluorescent dye (with excitation: 485 nm, emission: 498 nm, and a detection channel of SYBR® Green I or a FAM channel). The kit and a technology for calibration of an isothermal PCR instrument meet calibration demands of the isothermal PCR instrument and fill a technical gap.

Abstract: A liquid mixing device includes: a cup body provided with an accommodating cavity; a cup holder, the cup body being detachably supported on the cup holder; and a Venturi structure integrally formed with the cup holder and located on a side of the cup body, the Venturi structure including a mixing cavity, a liquid inlet channel connected to the mixing cavity, a steam channel for connecting a steam source and an outlet channel for outputting, the steam channel and the outlet channel being connected to the mixing cavity, the liquid inlet channel being connected to the accommodating cavity through a liquid conveying pipeline, and the liquid inlet channel being connected to the liquid conveying pipeline at an angle. The complete Venturi structure is integrated with the cup holder, so that the number of parts is reduced, thereby making mounting and disassembly more convenient, thus providing great convenience to users.

Abstract: A nanonization method for cannabidiol (CBD) includes following steps: the CBD is dissolved in a good solvent to obtain a CBD-good solvent solution, the CBD-good solvent solution is added to aqueous solution of a stabilizer to obtain mixed solution, the mixed solution is ultrasonicated followed by removing the good solvent by rotary evaporation from the mixed solution to obtain a nanosized CBD suspension. The stabilizer includes one or more selected from the group consisting of poloxamer, tween, polyoxyethylene alkyl ether, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose and carboxymethyl chitosan. Particle size of the CBD is reduced in the nanonization method for the CBD through the nanonization of insoluble drugs to obtain the nanosized CBD suspension. In the nanosized CBD suspension, nanosized CBD has high solid content. The nanonization method for the CBD achieves solubilization of the CBD.

Abstract: A hydrogel microneedle patch based on a three-dimensional framework structure is provided and includes a hydrogel microneedle. A raw material of the hydrogel microneedle includes polyvinyl alcohol and aqueous dispersion of acrylic resin. the hydrogel microneedle is obtained by uniformly mixing and molding of the aqueous dispersion of acrylic resin and the polyvinyl alcohol. The hydrogel microneedle patch has good strength, excellent swelling property and puncture property. In addition, a preparation method and an application of hydrogel microneedle patch are also provided.

Abstract: An insoluble transdermal microneedle patch, includes microneedles and a backing. The microneedles include bases and needlepoints located on the base, and materials made for the microneedles include crosslinked sodium alginate. The backing is connected with the bases, and parts of the backing corresponding to the needlepoints are hollow portions. The microneedle patch can act in the skin for a long time, during it is used for transdermal delivery, drugs can enter skin micropores to be absorbed into a body through pores formed after swelled microneedles acting on the skin absorbs water, thereby increasing a bioavailability of the drugs during the transdermal delivery. After drug administration end, the microneedles are completely removed without increasing a metabolic burden in the body, soluble materials are prevented from being accumulated in the body, and the microneedles have good biological safety. A preparation method of the insoluble transdermal microneedle patch and application thereof are provided.

Abstract: An insoluble transdermal microneedle patch, includes microneedles and a backing. The microneedles include bases and needlepoints located on the base, and materials made for the microneedles include crosslinked sodium alginate. The backing is connected with the bases, and parts of the backing corresponding to the needlepoints are hollow portions. The microneedle patch can act in the skin for a long time, during it is used for transdermal delivery, drugs can enter skin micropores to be absorbed into a body through pores formed after swelled microneedles acting on the skin absorbs water, thereby increasing a bioavailability of the drugs during the transdermal delivery. After drug administration end, the microneedles are completely removed without increasing a metabolic burden in the body, soluble materials are prevented from being accumulated in the body, and the microneedles have good biological safety. A preparation method of the insoluble transdermal microneedle patch and application thereof are provided.

Abstract: The present application discloses a coated microneedle with a multilayer structure, including a base, a needle tip on the base, and a functional coating. The functional coating includes a content including a water-soluble polymer material and an active ingredient, and a sustained-release layer wrapping the content. The sustained-release layer covers the needle tip. The coated microneedle can prevent a drug-containing matrix from being quickly dissolved and dispersed, prevent the active ingredient from exuding along with tissues at an action site, and increase the drug intake. The present application further discloses a method for preparing the coated microneedle and a microneedle patch including the coated microneedle.

Abstract: Disclosed are a heat-resistant implantable polymer microneedle and a preparation method therefor and an application thereof. The microneedle comprises a needle tip, a needle body, and a base, wherein the needle tip comprises a homogeneous system formed by mixing a biodegradable macromolecular material which has a glass transition temperature of 35-65° C. and is difficultly soluble in water and a macromolecular material having a glass transition temperature higher than that of the biodegradable macromolecular material. The microneedle has good heat resistance and puncture property.

Abstract: An implantable sustained-release microneedle patch and a preparation method therefor. The implantable sustained-release microneedle comprises a needle tip, a needle body, and a base. The needle tip comprises a needle tip center layer and a needle tip outer layer. The needle tip center layer is formed of a matrix comprising a biodegradable water-insoluble polymer material. The needle tip outer layer, the needle body, and the base are formed of a matrix comprising a water-soluble polymer material. The microneedle patch comprises the microneedle and absorbs the moisture of the skin when the microneedle acts on skin, so that the base and the needle body are quickly separated from the needle tip within 0.5-2 h. After the base is removed, the needle tip will be left in skin, and the user does not need the patch sticking for a long time to ensure long-term release of a drug in the body.

Abstract: An electrical energy storage unit and control system, and applications thereof. In an embodiment, the electrical energy storage unit includes a battery system controller and battery packs. Each battery pack has battery cells, a battery pack controller that monitors the cells, a battery pack cell balancer that adjusts the amount of energy stored in the cells, and a battery pack charger. The battery pack controller operates the battery pack cell balancer and the battery pack charger to control the state-of-charge of the cells. In an embodiment, the cells are lithium ion battery cells.

Abstract: An electrical energy storage unit and control system, and applications thereof. In an embodiment, the electrical energy storage unit includes a battery system controller and battery packs. Each battery pack has battery cells, a battery pack controller that monitors the cells, a battery pack cell balancer that adjusts the amount of energy stored in the cells, and a battery pack charger. The battery pack controller operates the battery pack cell balancer and the battery pack charger to control the state-of-charge of the cells. In an embodiment, the cells are lithium ion battery cells.

Abstract: A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.

Abstract: An apparatus for automatically testing CMOS magnetoresistive biochips is disclosed. The apparatus includes: means for directly or indirectly applying physical pressure to the fluid pumping chamber in a cartridge; a liquid injector for injecting liquid into the reaction chamber in the cartridge through an inlet or inlets in fluid connection to said reaction chamber; a CMOS magnetoresistive biochip located in the reaction chamber in the cartridge; means for applying a magnetic field to said CMOS magnetoresistive biochip in the cartridge; an electronic module for communicating with and supplying power as well as control signals to said biochip; a microprocessor to control and coordinate the aforementioned components; and a user interface for information processing. The apparatus provided by the present invention reduces the complexity of operation and enhances the detection sensitivity to a great extent.

Abstract: A microfluidic cartridge with solution reservoir-pump chamber is disclosed. The microfluidic cartridge comprises a channel-chamber layer, a sealing layer, a printed circuit board bound with magnetoresistive biochip. The channel-chamber layer includes at least a waste reservoir, a reaction-detection chamber, a solution reservoir-pump chamber and a plurality of micro-channels. Said solution reservoir-pump chamber realizes both functions of solution reservoir and pump chamber in a single structure. Said sealing layer is sealed with said channel-chamber layer to form an integrated microfluidic system with at least a waste reservoir, a reaction-detection chamber, a solution inlet, a solution reservoir-pump chamber and a micro-channel. Said solution reservoir-pump chamber in the present invention consists of elastic objects inside for sealing and pumping. Under pressure, said elastic object propels solution in the reservoir into said reaction-detection chamber via channels of said plurality of micro-channels.

Abstract: A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.

Abstract: An apparatus for automatically testing CMOS magnetoresistive biochips is disclosed. The apparatus includes: means for directly or indirectly applying physical pressure to the fluid pumping chamber in a cartridge; a liquid injector for injecting liquid into the reaction chamber in the cartridge through an inlet or inlets in fluid connection to said reaction chamber; a CMOS magnetoresistive biochip located in the reaction chamber in the cartridge; means for applying a magnetic field to said CMOS magnetoresistive biochip in the cartridge; an electronic module for communicating with and supplying power as well as control signals to said biochip; a microprocessor to control and coordinate the aforementioned components; and a user interface for information processing. The apparatus provided by the present invention reduces the complexity of operation and enhances the detection sensitivity to a great extent.

Abstract: A microfluidic cartridge with solution reservoir-pump chamber is disclosed. The microfluidic cartridge comprises a channel-chamber layer, a sealing layer, a printed circuit board bound with magnetoresistive biochip. The channel-chamber layer includes at least a waste reservoir, a reaction-detection chamber, a solution reservoir-pump chamber and a plurality of micro-channels. Said solution reservoir-pump chamber realizes both functions of solution reservoir and pump chamber in a single structure. Said sealing layer is sealed with said channel-chamber layer to form an integrated microfluidic system with at least a waste reservoir, a reaction-detection chamber, a solution inlet, a solution reservoir-pump chamber and a micro-channel. Said solution reservoir-pump chamber in the present invention consists of elastic objects inside for sealing and pumping. Under pressure, said elastic object propels solution in the reservoir into said reaction-detection chamber via channels of said plurality of micro-channels.