Abstract: Methods and compositions for determining multiplex interactions between drugs and drug transporters using an intestinal tissue explant are provided.

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

Abstract: An ex vivo tissue composition comprising an isolated tissue explant and tissue graft is provided. Methods of making and using the tissue composition are also provided.

Abstract: The present disclosure provides branched poly(?-amino esters) (PBAEs) of Formula (I) made by reacting primary amines with diacrylates. Further provided herein are compositions comprising the polymers of Formula (I), and methods of using the compositions and polymers as described herein for the treatment of disease.

Abstract: A bulk superconductor device is disclosed, comprising a single grain RE-BCO element incorporating reinforcing fibres. The single grain (RE)BCO element comprises RE-211 pinning sites disposed in a RE-123 matrix and further comprises Ag. The reinforcing fibres comprise a ceramic such as SiC and a refractory metal such as W. The reinforcing fibres comprise a core formed of the refractory metal and a ceramic cladding surrounding the core. The device may be manufactured by a top seeded melt growth process or by a top seeded infiltration growth process.

Abstract: A multi-die system includes a non-volatile memory, a first die having a first operational clock, a second die having a second operational clock, and an arbiter. The first die includes a first bus, a first bus filter coupled to the first bus and the arbiter for controlling access signals, a first access controller coupled to the first bus filter, and a first input/output (I/O) filter coupled to the first access controller, the arbiter and the non-volatile memory for controlling access to the non-volatile memory. The second die includes a second bus, a second bus filter coupled to the second bus and the arbiter, a second access controller coupled to the second bus filter, and a second I/O filter coupled to the second access controller, the arbiter and the non-volatile memory. The first and second operational clocks are independent.

Abstract: A chip includes a level control circuit, an output circuit, a level supply circuit, and an output terminal. The level control circuit is configured to output a response signal in response to an operation mode of the chip. The output circuit has an output side, and the output side couples to the output terminal. When the operation mode of the chip is a working mode, the response signal is at a first level, and the output circuit is configured to output an output signal at the output terminal. When the operation mode of the chip is a power saving mode, the response signal is at a second level, the output side of the output circuit is in a floating state, and the level supply circuit is configured to provide a level voltage to the output terminal according to the response signal, so that the output terminal has a fixed level.

Abstract: Methods and compositions for determining multiplex interactions between drugs and drug transporters using an intestinal tissue explant are provided.

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

Abstract: Compositions and methods for effective delivery of oligonucleotide therapeutics, and in particular locked nucleic acid (AON)-containing gapmers, into the gastrointestinal (GI) tract are provided.

Abstract: A multi-die system includes a non-volatile memory, a first die having a first operational clock, a second die having a second operational clock, and an arbiter. The first die includes a first bus, a first bus filter coupled to the first bus and the arbiter for controlling access signals, a first access controller coupled to the first bus filter, and a first input/output (I/O) filter coupled to the first access controller, the arbiter and the non-volatile memory for controlling access to the non-volatile memory. The second die includes a second bus, a second bus filter coupled to the second bus and the arbiter, a second access controller coupled to the second bus filter, and a second I/O filter coupled to the second access controller, the arbiter and the non-volatile memory. The first and second operational clocks are independent.

Abstract: This invention discloses a process for preparing rare earth containing hard alloy, comprising preparing metal carbide powder containing rare earth metals or cobalt powder containing rare earth metals by using wet coprecipitating method; according to the composition of alloy, at least one kind of the metal carbide powder containing rare earth metal and cobalt powder containing rare metals being mixed homogeneously with other raw materials, shaping and finally sintering under high temperature. The process of the invention is simple technologically. The properties of the products produced by the process of the invention are good, stable and repeatable.