Patents by Inventor Yunhui Zhang

Yunhui Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenylcarboxyamides as beta-secretase inhibitors
    Patent number: 7476764
    Abstract: There is provided a series of novel phenylcarboxyamides of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and Y as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by ?-secretase and, more specifically, inhibit the production of A?-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to ?-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: January 13, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong-Jin Wu, Yunhui Zhang
  • Novel phenylcarboxyamides as beta-secretase inhibitors
    Publication number: 20070032470
    Abstract: There is provided a series of novel phenylcarboxyamides of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and Y as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by ?-secretase and, more specifically, inhibit the production of A?-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to ?-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
    Type: Application
    Filed: July 27, 2006
    Publication date: February 8, 2007
    Inventors: Yong-Jin Wu, Yunhui Zhang
  • O-derivatized nocathiacin derivatives
    Patent number: 7022667
    Abstract: The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: April 4, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, B. Narasimhulu Naidu, Margaret E. Sorenson, Alicia Regueiro-Ren, Timothy P. Connolly, John D. Matiskella, Oak K. Kim, Yunhui Zhang, Dane M. Springer, Jason Goodrich, Yasutsugu Ueda, Joanne J. Bronson
  • Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 6933294
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, halogen, alkyl, or perfluoroalkyl; R4 is an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and R7 is a substituent on A as defined in the specification.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: August 23, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Makonen Belema, Amy Bunker, Van Nguyen, Francis Beaulieu, Carl Ouellet, Anne Marinier, Stephan Roy, Xuejie Yang, Yuping Qiu, Yunhui Zhang, Alain Martel, Christopher Zusi
  • Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
    Publication number: 20040058930
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: March 27, 2003
    Publication date: March 25, 2004
    Inventors: Makonen Belema, Amy Bunker, Van Nguyen, Francis Beaulieu, Carl Ouellet, Anne Marinier, Stephan Roy, Xuejie Yang, Yuping Qiu, Yunhui Zhang, Alain Martel, Christopher Zusi
  • O-derivatized nocathiacin derivatives
    Publication number: 20040018963
    Abstract: The present invention provides compounds of formula I 1
    Type: Application
    Filed: July 3, 2002
    Publication date: January 29, 2004
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, B. Narasimhulu Naidu, Margaret E. Sorenson, Alicia Regueiro-Ren, Timothy P. Connolly, John D. Matiskella, Oak K. Kim, Yunhui Zhang, Dane M. Springer, Jason Goodrich, Yasutsugu Ueda, Joanne J. Bronson
  • HIV integrase inhibitors
    Patent number: 6548546
    Abstract: The present invention relates to HIV integrase inhibitors of the formula wherein R1 and Z are as defined in the specification.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: April 15, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Walker, Timothy D. Johnson, Oak K. Kim, Yunhui Zhang
  • HIV integrase inhibitors
    Publication number: 20020123527
    Abstract: The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the following formula, or a tautomer of said compound, or a pharmaceutically acceptable salt, solvate or prodrug of said compound or of a tautomer thereof.
    Type: Application
    Filed: February 28, 2002
    Publication date: September 5, 2002
    Inventors: Michael A. Walker, Timothy D. Johnson, Oak K. Kim, Yunhui Zhang
  • Water soluble thiazolyl peptide derivatives
    Publication number: 20020065219
    Abstract: Novel thiazolyl peptide compounds useful for the treatment of serious bacterial infections, and pharmaceutical compositions thereof are provided.
    Type: Application
    Filed: August 13, 2001
    Publication date: May 30, 2002
    Inventors: B. Narasimhulu Naidu, Wenying Li, Kin S. Lam, Margaret E. Sorenson, John A. Wichtowski, Timothy P. Connolly, Yasutsugu Ueda, Joanne J. Bronson, Yunhui Zhang, Oak K. Kim