Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.

Abstract: Provided is a pig genome-wide specific sgRNA library, a preparation method therefor, and an application thereof. The sgRNA is targeted at a pig genome-wide protein-coding gene, lincRNA and/or miRNA. Specifically, an sgRNA construct has the following structure: AL-N20-AR, wherein AL is the left homology arm sequence located at the upstream of the coding sequence of a pig specific SgRNA, N20 is the coding sequence of the pig specific SgRNA, and AR is a right homology arm sequence located at the downstream of the coding sequence of the pig specific sgRNA. The sgRNA library can be used for screening functional genes of a pig or for preparing a kit.

Abstract: A cable-stayed jacking reversing type sixteen-wheel four-way shuttle comprises a supporting frame, a transverse movement drive mechanism, a longitudinal movement drive mechanism and a cable-stayed reversing jacking mechanism, wherein the transverse movement drive mechanism includes transverse driving wheels and first/second/third transverse driven wheels; the longitudinal movement drive mechanism includes first/second longitudinal driving wheels and first/second longitudinal driven wheels; and, the cable-stayed reversing jacking mechanism includes jacking transverse plates and cable-stayed jacking blocks, in which a ball bearing sleeve is movably arranged in a jacking shaft hole, a cable-stayed jacking shaft is arranged between the front and rear sides of the ball bearing sleeve, and the cable-stayed jacking blocks are connected with each other through ball screws.

Abstract: A network device role self-adaptive method and apparatus are provided. Specifically, a first network device and a neighbor network device both determine their respective priority according to information including a connection result between the corresponding network device itself and a server; the first network device receives a second start frame which is sent by the neighbor network device and comprises the priority of the neighbor network device, and then determines whether its own priority and the priority of the neighbor network device meet preset conditions; and if yes, when the priority of the first network device is higher than the priority of the neighbor network device, the first network device determines its own role as an authentication access controller, and when the priority of the first network device is lower than the priority of the neighbor network device, the first network device determines its own role as a request device.

Abstract: A natural edible shampoo and preparation method thereof, the components comprises fatty acyl lactyl-lactic acid, arginine, vegetable oleic acid monoglyceride, plant phospholipid, ?-polylysine, ethyl lauroyl arginate hydrochloride, inulin, polyol and so on. It resist static electricity, improve the smoothness of hair, prevent pore clogging, and has good flowability at a low temperature. The shampoo overturns the classic concept of existing cationic hair care (large irritation), uses nearly non-irritant natural anionic wash and care main ingredients, relies on a non-enclosed protein peptide/low HLB value oiliness agent film-forming smoothing system, avoids a cationic polymer/silicone oil hair-care pattern with intensive negative effect, and protects the original ecological environment of hair and scalp, so that a final product gains the smooth experience feeling of organic silicone oil, thereby creating a new path for research and development of food and cosmetic-type wash and care two-in-one shampoos.

Abstract: A roller reversing and jacking device for handling equipment comprises a directional roller set, at least one set of reversing and jacking assemblies and a reversing roller set. The reversing and jacking assemblies comprises: a jacking slider restricted to and disposed on the frame through a slider guide post; a reversing and jacking eccentric shaft correspondingly disposed on the jacking slider, comprising an eccentric shaft segment, an eccentric roller and a transmission shaft segment; and a reversing and jacking drive motor connected to and/or disconnected from one end of the transmission shaft segment, and the reversing and jacking drive motor fixedly mounted on the frame.

Abstract: The present disclosure relates to a multifunctional therapeutic biological material and preparation method thereof. The process steps of the preparation method are as follows: (1) preparing various three-dimensional micro/nano composite structure on the surface of a biomedical material by using femtosecond laser double pulses; (2) further preparing a nano-flower structure on the three-dimensional micro/nano composite structure by using hydrothermal synthesis method to construct a heterogeneous structure consisting of the three-dimensional micro/nano composite structure and the nano-flower structure; (3) putting the prepared heterogeneous structure into a mixed solution containing gold ions and platinum ions, and by using ultraviolet light reduction method, reducing in situ into gold-platinum bimetallic nanoparticles on the heterogeneous structure to obtain the multifunctional therapeutic biological material.

Abstract: A machine learning-based method for automatically determining abnormal points of a single indicator includes step 1: randomly selecting M sample points from training data as subsamples, and putting them into a root node of a tree; and step 2: randomly specifying a data dimension for projection, and randomly generating a cutting point p in data of a current node, where the cutting point is generated between a maximum value and a minimum value of the specified dimension in the data of the current node. The present disclosure optimizes conventional data analysis linear model functions and regression model functions, constructs a computer neural network in the algorithm, puts multiple perceptron parameters in a multi-layer network for learning and training, and adopts the principle of principal component analysis, to find out the abnormal data that violates the data correlation.

Abstract: The disclosure provides a fast and stable genomic breeding value evaluating method for animal individuals, and relates to the technical field of animal breeding. In the method, HIBLUP is adopted to perform genomic breeding value prediction using phenotype, genotype and pedigree information, and the final output includes estimated genetic value of individuals, additive effect and dominant effect values of each individual, and back solution values of each genetic marker effect used on genotyping chips. The pedigree, phenotypic and genotypic information can be fully used to predict genetic (additive and dominant) values for each individual animal and as well as effect values for each SNP marker, and the most advanced genomic breeding value prediction and variance component estimation algorithm are realized to realize genomic selection.

Abstract: Disclosed is an intelligent frequency-shift anti-interference autonomous communication method based on electromagnetic environment learning, applied to an intelligent frequency-shift anti-interference autonomous communication system based on electromagnetic environment learning. The method comprises a communication link establishing process and an intelligent frequency-shift anti-interference process in the communication process. In the communication link establishing process, a communication initiator initiates communication to a communication responder, and the communication initiator and the communication responder perform frequency point matching, and finally negotiate to establish a communication connection.

Abstract: A roller reversing and jacking device for handling equipment comprises a directional roller set, at least one set of reversing and jacking assemblies and a reversing roller set. The reversing and jacking assemblies comprises: a jacking slider restricted to and disposed on the frame through a slider guide post; a reversing and jacking eccentric shaft correspondingly disposed on the jacking slider, comprising an eccentric shaft segment, an eccentric roller and a transmission shaft segment; and a reversing and jacking drive motor connected to and/or disconnected from one end of the transmission shaft segment, and the reversing and jacking drive motor fixedly mounted on the frame.

Abstract: Disclosed is an intelligent frequency-shift anti-interference autonomous communication method based on electromagnetic environment learning, applied to an intelligent frequency-shift anti-interference autonomous communication system based on electromagnetic environment learning. The method comprises a communication link establishing process and an intelligent frequency-shift anti-interference process in the communication process. In the communication link establishing process, a communication initiator initiates communication to a communication responder, and the communication initiator and the communication responder perform frequency point matching, and finally negotiate to establish a communication connection.

Abstract: Provided is a pig genome-wide specific sgRNA library, a preparation method therefor, and an application thereof. The sgRNA is targeted at a pig genome-wide protein-coding gene, lincRNA and/or miRNA. Specifically, an sgRNA construct has the following structure: AL-N20-AR, wherein AL is the left homology arm sequence located at the upstream of the coding sequence of a pig specific SgRNA, N20 is the coding sequence of the pig specific SgRNA, and AR is a right homology arm sequence located at the downstream of the coding sequence of the pig specific sgRNA. The sgRNA library can be used for screening functional genes of a pig or for preparing a kit.