Abstract: The present disclosure provides pharmaceutical compositions for delivery of viral antigens (e.g., a viral vaccine) and related technologies (e.g., components thereof and/or methods relating thereto).

Abstract: A computer-implemented method for verifying ownership of a deep learning (DL) model includes: obtaining a Gaussian mixture distribution for initialization of a DL model to be verified, a model chain to be verified of the DL model, and a corresponding verification dataset, wherein the model chain is composed of model parameters of the DL model in each training epoch; calculating, based on the Gaussian mixture distribution, the model chain and the verification dataset, an accuracy monotonicity index, a parameter distance monotonicity index, a parameter distribution continuity index, an initial parameter distribution index, an initial parameter randomness index and a model chain distance index; and obtaining an ownership verification result by determining an authenticity of the model chain based on the accuracy monotonicity index, the parameter distance monotonicity index, the parameter distribution continuity index, the initial parameter distribution index, the initial parameter randomness index and the model c

Abstract: The present disclosure provides technologies for identifying, characterizing, and/or monitoring sequences of a variant of a reference infectious agent (e.g., but not limited to viral variants, for example in some embodiments SARS-CoV-2 variants) for transmissibility factors and/or immune escape potential, and/or for detecting and/or monitoring variants in environmental or biological samples, and/or for designing, preparing, and/or administering vaccines for such variants.

Abstract: A method is provided for identifying a number of variants of concern of a reference disease associated immunogen. The method uses a language model to perform inference on data representing each of a plurality of variants and data representing the reference immunogen. For each of the plurality of variants and the reference immunogen, a characteristic vector is derived from an output feature map of a hidden layer of the language model. For each of the plurality of variants, a measure of distance is generated for the variant that includes calculating a measure of distance between the characteristic vector of the variant and the characteristic vector of the reference immunogen. A semantic change score is calculated for each variant based on the generated measure of distance for that variant. A variant of the reference immunogen is selected based, at least in part, on the generated the semantic change scores.

Abstract: The present disclosure relates to the field of biomedicine, in particular to an anti-PD-L1 antibody and the use thereof. The anti-PD-L1 antibody or the antigen-binding fragment thereof provided in the present disclosure binds to a PD-L1 protein with a high affinity and high specificity, can effectively block the interaction between PD-L1 expressed on a cell surface and PD-1, and has the biological function activity of stimulating the production of cytokine, and has wide application prospects.

Abstract: The disclosure provides a micro control device for simulating the electric thermal field change of a plate/strip, comprising a plate shape simulating test platform, a high current regulating power supply, a current regulating device, a thermal imager, a thermocouple, a non-contact type full field strain gauge, a high-power current control device and an electro-plastic control system; for a plate/strip with large width to thickness ratio and high hardness and brittleness alloy, different numbers of electrodes are arranged laterally along the movable supporting beam. A high-power current control device is used to realize the sub-regional control of the electric field, thermal field and stress field of the plate/strip; at the same time, the movable supporting beam and tension sensor are used to test the working conditions of the plate/strips with different lengths and widths, to simulate the instantaneous synchronous entanglement process between different fields.

Abstract: The invention discloses high-strength glass-ceramic-based lightweight aggregates and the preparation method thereof. The mass ratio of raw material components is 50-70 parts of engineering muck, 20-40 parts of glass, 3-7 parts of calcium carbonate, 3-7 parts of magnesium oxide, and 2-10 parts of a nucleating agent; the nucleating agent is at least one of calcium fluoride, titanium dioxide, and chromium oxide. After crushing, mixing, and granulating, spherical particles with a particle size of 10-12 mm are formed; and then the product can be obtained after drying, sintering, and cooling. The obtained lightweight aggregate from the invention has a diopside matrix which provides high strength and a low water absorption rate at low densities. Moreover, waste glass and engineering muck could be utilized with high value.

Abstract: The invention discloses high-strength glass-ceramic-based lightweight aggregates and the preparation method thereof. The mass ratio of raw material components is 50-70 parts of engineering muck, 20-40 parts of glass, 3-7 parts of calcium carbonate, 3-7 parts of magnesium oxide, and 2-10 parts of a nucleating agent; the nucleating agent is at least one of calcium fluoride, titanium dioxide, and chromium oxide. After crushing, mixing, and granulating, spherical particles with a particle size of 10-12 mm are formed; and then the product can be obtained after drying, sintering, and cooling. The obtained lightweight aggregate from the invention has a diopside matrix which provides high strength and a low water absorption rate at low densities. Moreover, waste glass and engineering muck could be utilized with high value.

Abstract: The present invention provides a dynamic contact heat transfer simulation device for rolling heavy-load deformation zone. The device includes a control system, a data acquisition system, a pressure-adjustable fixed cold end, a rotating chuck, a temperature-adjustable heat-conducting rod and an speed-adjustable rotation hot end; the device utilizes the rotating chuck and the speed-adjustable rotating hot end to adjust the rotation speed in real time according to the actual rolling conditions, simulate the working conditions of the actual rolling heavy-load deformation zone, and accurately obtain the dynamic heat transfer coefficient of the rotating contact interface under variable load pressure conditions.

Abstract: An integrated imaging display system is provided. The integrated imaging display system includes: a light source, a converging lens, an illumination microlens array, and a projection microlens array, where illumination microlens units in the illumination microlens array and projection microlens units in the projection microlens array are disposed in a one-to-one correspondence, and the converging lens converts all light emitted by the light source into parallel light and then irradiates the parallel light to the illumination microlens array; a sub-image is provided on a side of each of the illumination microlens units close to the projection microlens unit; all light emitted by each of the illumination microlens units is irradiated on a corresponding projection microlens unit after passing through the sub-image, and the projection microlens array displays an image of the sub-image.

Abstract: An integrated imaging display system is provided. The integrated imaging display system includes: a light source, a converging lens, an illumination microlens array, and a projection microlens array, where illumination microlens units in the illumination microlens array and projection microlens units in the projection microlens array are disposed in a one-to-one correspondence, and the converging lens converts all light emitted by the light source into parallel light and then irradiates the parallel light to the illumination microlens array; a sub-image is provided on a side of each of the illumination microlens units close to the projection microlens unit; all light emitted by each of the illumination microlens units is irradiated on a corresponding projection microlens unit after passing through the sub-image, and the projection microlens array displays an image of the sub-image.

Abstract: The disclosure provides a micro control device for simulating the electric thermal field change of a plate/strip, comprising a plate shape simulating test platform, a high current regulating power supply, a current regulating device, a thermal imager, a thermocouple, a non-contact type full field strain gauge, a high-power current control device and an electro-plastic control system; for a plate/strip with large width to thickness ratio and high hardness and brittleness alloy, different numbers of electrodes are arranged laterally along the movable supporting beam. A high-power current control device is used to realize the sub-regional control of the electric field, thermal field and stress field of the plate/strip; at the same time, the movable supporting beam and tension sensor are used to test the working conditions of the plate/strips with different lengths and widths, to simulate the instantaneous synchronous entanglement process between different fields.

Abstract: The present invention provides a dynamic contact heat transfer simulation device for rolling heavy-load deformation zone. The device includes a control system, a data acquisition system, a pressure-adjustable fixed cold end, a rotating chuck, a temperature-adjustable heat-conducting rod and an speed-adjustable rotation hot end; the device utilizes the rotating chuck and the speed-adjustable rotating hot end to adjust the rotation speed in real time according to the actual rolling conditions, simulate the working conditions of the actual rolling heavy-load deformation zone, and accurately obtain the dynamic heat transfer coefficient of the rotating contact interface under variable load pressure conditions.