Abstract: An edged cataplasm and a manufacturing process are disclosed. The edged cataplasm includes a support layer; a drug layer, which adheres to the bottom of the support layer; a cross-type release film, which adheres to the bottom of the drug layer. The cross-type release film includes a first-release film piece and a second-release film piece, and the adjacent edges of the first-release film piece and the second-release film piece are partially overlapped. In addition, the edged cataplasm further includes a waterproof-breathable adhesive layer, which adheres to the top of the support layer and coated with silver ions or a nano antibiotic layer; a polyethylene terephthalate (PET) film, which adheres to the top of the waterproof-breathable adhesive layer. The PET film includes a first part and a second part, and the adjacent edges of the first part and the second part are arranged as an aligned S-shaped edge.