Patents by Inventor Yunsheng Li

Yunsheng Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140120552
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
    Type: Application
    Filed: October 14, 2013
    Publication date: May 1, 2014
    Applicant: QUIDEL CORPORATION
    Inventors: LEONARD KOHN, JIM BROWN, DAVID SCHOLL, YUNSHENG LI, GIORGIO NAPOLITANO
  • Patent number: 8563257
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: October 22, 2013
    Assignee: Diagnostic Hybrids, Inc.
    Inventors: Leonard Kohn, Jim Brown, David Scholl, Yunsheng Li, Giorgio Napolitano
  • Publication number: 20130065252
    Abstract: The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated with the presence of TBI and/or TSI, for monitoring the progress of disease and/or treatment regimens, therapeutics, vaccines, etc., and for assisting clinicians in making treatment decisions.
    Type: Application
    Filed: September 9, 2011
    Publication date: March 14, 2013
    Inventors: Yunsheng Li, Paul D. Olivo, Jaekyung Kim
  • Publication number: 20100233674
    Abstract: The invention provides cell lines that are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic cells with increased sensitivity to infection by influenza A, influenza B, or parainfluenza 3 viruses, or which are capable of enhanced productivity of infectious virions. The invention is suitable for use in culturing clinical influenza and parainfluenza virus isolates and for the production of influenza and parainfluenza virus for vaccine formulations, as antigen preparations for diagnostic applications, and for screening antiviral drugs.
    Type: Application
    Filed: December 19, 2006
    Publication date: September 16, 2010
    Applicants: University Hospitals of Cleveland, Diagnostic Hybrids, Inc.
    Inventors: Yung T. Huang, Yunsheng Li
  • Publication number: 20090325177
    Abstract: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
    Type: Application
    Filed: June 12, 2009
    Publication date: December 31, 2009
    Inventors: Leonard Kohn, Jim Brown, David Scholl, Yunsheng Li, Giorgio Napolitano
  • Patent number: 5846949
    Abstract: The present invention relates to a gene expression system in eukaryotic cells. In particular, it relates to a self-initiating and self-sustaining gene expression system utilizing an RNA polymerase prebound to a DNA construct before the introduction of the complex into cells. This system is capable of functioning in the cell cytoplasm without integration into the genome of host cells, and does not require host cell factors for initiation and maintenance of gene expression. Therefore, the invention has a wide range of applications in in vitro and in vivo gene expression, including gene therapy in resting cells.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: December 8, 1998
    Assignee: Ohio University Edison Animal Biotechnology Institute
    Inventors: Thomas E. Wagner, Xiaozhuo Chen, Yunsheng Li
  • Patent number: 5591601
    Abstract: The present invention relates to a gene expression system in eukaryotic cells. In particular, it relates to a self-initiating and self-sustaining gene expression system utilizing an RNA polymerase prebound to a DNA construct before the introduction of the complex into cells. This system is capable of functioning in the cell cytoplasm without integration into the genome of host cells, and does not require host cell factors for initiation and maintenance of gene expression. Therefore, the invention has a wide range of applications in in vitro and in vivo gene expression, including gene therapy in resting cells.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: January 7, 1997
    Assignee: Ohio University Edison Animal Biotechnology Institute
    Inventors: Thomas E. Wagner, Xiaozhuo Chen, Yunsheng Li