Abstract: An on-line multi-component gas analysis system based on a spectral absorption technology includes a housing, wherein the housing includes an air inlet hole and an air outlet hole which are respectively connected with an air inlet pipe and an air outlet pipe, and the housing includes a dust removal and dehumidification device, a micro vacuum pump, an electronic flowmeter, and a plurality of different gas sensors; the dust removal and dehumidification device, which is configured to perform dust removal and dehumidification treatment on a gas entering from the air inlet hole; the micro vacuum pump, one end of which being connected with the dust removal and dehumidification device through a pipeline, and the other end of which being connected with the electronic flowmeter; and the plurality of different gas sensors. The disclosure includes an analysis method based on the on-line multi-component gas analysis system based on a spectral absorption technology.

Abstract: A plasma-facing component of a fusion reactor divertor, including an inner target transition support and a dome transition support which are integrated into an inner target-dome transition support. The inner target-dome transition support and an outer horizontal target transition support are each prepared from two materials. The channel connection inside the inner target-dome transition support and the outer horizontal target transition support is realized through an S-shaped flow channel and a collector box. In V-shaped regions of inner and outer targets, a plasma-facing unit is connected to the collector box in the transition support via a bending tube, and is communicated with a coolant flowing through horizontal and vertical targets through an intermediate flow channel in the transition block. A method of preparing the plasma-facing component is further provided.

Abstract: An ambient pressure compensation structure for an ultraviolet difference spectrum gas sensor includes a closed box, an ultraviolet difference spectrum gas sensor, a digital pressure sensor, a thermostatic controller, an industrial control computer, a pressure regulating assembly and a limiting partition; the pressure regulating assembly and the limiting partition are arranged inside the closed box, the pressure regulating assembly comprises a piston, a regulating rod and a driving motor, the left side of the piston is connected with the regulating rod, the front end of the regulating rod penetrates out of the closed box and is connected with the driving motor, and the piston divides the interior of the closed box into a pressure regulating air chamber and a working air chamber. Also disclosed is an ambient pressure compensation method for an ultraviolet difference spectrum gas sensor.

Abstract: Disclosed are a method and device for evaluating damage caused by secondary stress to a vacuum vessel, a terminal device, and a medium, to perform following steps: obtaining secondary stress of a vacuum vessel that passes a primary-stress failure evaluation; obtaining structural damage parameters of the vacuum vessel when determining, based on evaluation parameters for the primary-stress failure evaluation of the vacuum vessel and the obtained secondary stress, that the vacuum vessel meets a precondition for a progressive deformation; and determining, based on the obtained structural damage parameters, whether the vacuum vessel meeting the precondition for the progressive deformation experiences structural damage due to the progressive deformation. In this way, a vacuum vessel of a nuclear fusion reactor can be evaluated based on damage caused by the secondary stress.

Abstract: The present disclosure provides a class of conjugates of general formula (X), a class of TLR9 agonist derivatives, such as formula (I), (XX), and (XXI), certain diastereomers of STING agonists, a class of STING agonist derivatives, such as formula (XXVIV), a class of heterocyclic compounds of general formula (II), a class of heterocyclic compounds of general formula (III), as defined herein. A1, A2, T, Z1, Z2, Z3, b1, and b2, in formula (X) are defined herein. The conjugate provides unique properties that are based upon the properties of the therapeutic agents that are part of the conjugate. Also provided are methods of synthesis and use of compounds.

Abstract: A superconducting eddy-current brake for high-speed trains includes a pair of superconducting magnet units with alternate arrangement of N and S poles; and a cryogenic system. The superconducting magnet units are fixed on a bottom of a bogie of the train and an air gap is provided between the superconducting magnet units and a top surface of a rail below the bogie. The cryogenic system is provided on the bogie of the train. Each superconducting magnet unit is embedded with a superconducting container including a coil case, a thermal shield and a Dewar successively from inside to outside. The coil case is filled with liquid helium. A superconducting coil is provided in the coil case and immersed in the liquid helium. A high-vacuum environment is provided in the thermal shield. Liquid nitrogen inlet and outlet pipes are provided on an outer wall of the thermal shield.

Abstract: The present disclosure relates to a compound of formulae (I) or (II), or a pharmaceutically acceptable salt, a solvate, a hydrate thereof, a pharmaceutical composition comprising a compound of formulae (I) or (II), and use thereof, wherein various Markush groups are as described herein.

Abstract: Patient sitting equipment for radiotherapy, including an installation platform, a treatment couch assembly, a support and adjustment assembly and a 3D imaging assembly. The treatment couch assembly is configured to fix a patient. The support and adjustment assembly is configured to adjust a position of the treatment couch assembly with respect to the installation platform. The 3D imaging assembly includes a column assembly and a 3D imaging device. The column assembly is arranged at the installation platform, and extends along the vertical direction. The 3D imaging device is movably arranged at the column assembly, and is corresponding to the treatment couch assembly in a horizontal projection direction. The 3D imaging device is configured to scan the patient.

Abstract: A superconducting magnet system and a cyclotron using the same. The superconducting magnet system includes a cryogenic device, a superconducting device and a protecting module. The cryogenic device includes a refrigerating machine and a cryogenic container assembly. The cryogenic container assembly includes a first container end, a connecting tube and a second container end. The first container end is communicated with the second container end through the connecting tube. The superconducting device includes a superconducting coil arranged in the first container end and immersed in a liquid or gaseous cooling medium. The protecting module is connected to the superconducting coil and is configured to protect the superconducting coil if the superconducting coil suffers a quench.

Abstract: A bifilar winding system for the manufacture of poloidal field superconducting magnets for nuclear fusion includes two superconducting coil winding production lines which are symmetrically arranged, a dropping fixture, a rotary platform and a winding mold, and an automatic control system. Each of the two winding production lines includes a conductor unwinding device, a straightener, an ultrasonic cleaning machine, a sandblasting and cleaning machine, a bending machine, an inter-turn insulation taping machine. During the winding of a coil, a superconducting conductor is unwound by the conductor unwinding device under the control of the automatic control system, then straightened, ultrasonically cleaned, sandblasted and cleaned, and bent into a desired radius, then wrapped with multiple layers of insulating tape by the inter-turn insulation taping machine, and finally fixed, by the dropping fixture, precisely on the rotary platform at a correct position within a profile of the winding mold.

Abstract: The present invention discloses an inter-layer transition forming machine for winding of a large-sized superconducting coil. A vertically movable forming mechanism and a horizontally movable forming mechanism are mounted on a fixing plate. When the winding of a large-sized superconducting coil performs inter-layer transition, an armored superconducting conductor is clamped by wedge clamping mechanisms with right- and left-handed threads on the vertically movable forming mechanism and the horizontally movable forming mechanism, and a reference line on the conductor is ensured to be aligned with a reference line on a forming mold. The vertically movable forming mechanism is pressed down, under the drive of a double-acting hydraulic cylinder, in a vertical direction to form inter-layer transition, and the horizontally movable forming mechanism moves in a horizontal direction according to the reduction of the vertically movable forming mechanism.

Abstract: Patient sitting equipment for radiotherapy, including an installation platform, a treatment couch assembly, a support and adjustment assembly and a 3D imaging assembly. The treatment couch assembly is configured to fix a patient. The support and adjustment assembly is configured to adjust a position of the treatment couch assembly with respect to the installation platform. The 3D imaging assembly includes a column assembly and a 3D imaging device. The column assembly is arranged at the installation platform, and extends along the vertical direction. The 3D imaging device is movably arranged at the column assembly, and is corresponding to the treatment couch assembly in a horizontal projection direction. The 3D imaging device is configured to scan the patient.

Abstract: The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that ae based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

Abstract: A superconducting magnet system and a cyclotron using the same. The superconducting magnet system includes a cryogenic device, a superconducting device and a protecting module. The cryogenic device includes a refrigerating machine and a cryogenic container assembly. The cryogenic container assembly includes a first container end, a connecting tube and a second container end. The first container end is communicated with the second container end through the connecting tube. The superconducting device includes a superconducting coil arranged in the first container end and immersed in a liquid or gaseous cooling medium. The protecting module is connected to the superconducting coil and is configured to protect the superconducting coil if the superconducting coil suffers a quench.

Abstract: Provided are anti-claudin 18.2 (CLDN18.2) antibodies and fragments thereof. Also provided are isolated nucleic acid molecules that encode anti-CLDN18.2 antibodies, vectors comprising such nucleic acid, and host cells comprising such vectors or nucleic acids. Provided are methods of making anti-CLDN18.2. Also provided are related pharmaceutical compositions and methods using such pharmaceutical compositions in the treatment of disorders associated with aberrant CLDN18.2 expression, such as cancers.

Abstract: The present disclosure provides variant CD80 polypeptides that have altered affinity for their cognate binding partners, and immunomodulatory fusion proteins comprising the variant CD80 polypeptides. The present disclosure also provides pharmaceutical compositions comprising such polypeptides and/or proteins and methods for modulating immune responses and/or treatment of cancer, infectious diseases, and/or immunological diseases.

Abstract: The present disclosure relates to a compound of formula (I), or a pharmaceutically acceptable salt, a solvate, a stereoisomer, or tautomer thereof, a pharmaceutical composition comprising a compound of formula (A) or formula (B), and any subgenera thereof, and use of said compounds and compositions thereof, wherein R1, R2, R3a, R3b, R5, R6, X1, X2, Y and n are described herein.

Abstract: The present disclosure relates to compounds of formula (AI), (I), (AII), and (II), or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, a pharmaceutical composition comprising a compound of formula (AI), (I), (AII), and (II), and use thereof, wherein R2, R3, R4, R5, R6, R7, R10, R11a, R11b, R12, R16, R19a, R19b, and R20 are described herein. Such compounds are envisioned useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, movement disorders, convulsive disorders, schizophrenin spectrum disorders, disorders of memory and/or cognition, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, or tinnitus etc.

Abstract: A feed-through ultrasonic cleaning system for winding of a superconducting coil, including a sealed chamber system, a main ultrasonic cleaning system, a deionized water spraying system, a compressed air blow-drying system, and an automatic control system. During the winding of an armored superconducting coil, a superconducting conductor which is fed at a constant speed successively passes through a sealed chamber, an ultrasonic cleaning chamber, a first compressed air blow-drying chamber, a deionized water spray chamber, and a second compressed air blow-drying chamber in the ultrasonic cleaning system.

Abstract: A superconducting magnet for eddy-current braking for a high-speed train. The superconducting magnet is fixed at a bottom of a bogie of the high-speed train through a connecting mechanism, and an air gap is formed between the superconducting magnet and a top of a guide rail below the bogie. The superconducting magnet after being excited generates an eddy-current effect with the guide rail of the high-speed train, so as to generate a braking force opposite to a traveling direction of the train, thereby braking the high-speed train. A liquid-level meter is provided on the superconducting magnet to detect a position of a cooling agent liquid level in real time. The superconducting magnet withstands vibration impact through elastic tie rod assemblies when the high-speed train is under operation, showing good adaptability.