Abstract: Disclosed in the present invention is a pharmaceutical composition, comprising: 1) a reagent for reducing bonding between an Fc receptor and an endogenous serum antibody, wherein the reagent comprises an immunoglobulin degrading enzyme or endo-glycosidase; and 2) a viral vector drug, wherein the viral vector drug is selected from an oncolytic virus and a viral vaccine. The pharmaceutical composition allows individual administration of the viral vector drug and the reagent. Further disclosed in the present invention are an application of the pharmaceutical composition in the preparation of a drug for treating or preventing disasters, and a method for applying the pharmaceutical composition to a subject to treat or prevent cancers or infections.

Abstract: Provided is an anti-HER2 bispecific antibody, comprising a first protein functional region and a second protein functional region for respectively recognizing extracellular domain II and extracellular domain IV of HER2. The first protein functional region comprises a first heavy chain and a first light chain. The second protein functional region comprises a second heavy chain and a second light chain. Also provided are pharmaceutical compositions comprising the bispecific antibody and an application thereof. The bispecific antibody and the pharmaceutical compositions containing the same can be used for cancer treatment.

Abstract: A speaker box with side acoustic emission structure is disclosed. The speaker box has a case having an acoustic window, a speaker unit mounted in the case and including a diaphragm, a voice coil and a magnetic circuit, the diaphragm disposed in the side of the acoustic window and not faced to the acoustic window and having a dome and a suspension surrounding the dome, the suspension comprising a first end close to the acoustic window and a second end away from the acoustic window, and the first end is lower than the second end along the vibrating direction.

Abstract: A speaker box includes a housing which has a receiving space and a side wall having a sound hole, and a sound generator received in the receiving space and including a diaphragm including a dome and a periphery connected to the dome. The periphery includes a near-end which is near the sounding hole and a far-end which is farther the sounding hole. A compliance of the near-end is less than a compliance of the far-end.

Abstract: A speaker box includes a housing which has a receiving space and a side wall having a sound hole, and a sound generator received in the receiving space and including a diaphragm including a dome and a periphery connected to the dome. The dome includes a near-end which is near the sounding hole and a far-end which is farther the sounding hole. A compliance of the near-end is less than a compliance of the far-end.

Abstract: A speaker box with side acoustic emission structure is disclosed. The speaker box has a cabinet having an acoustic window, a speaker unit mounted in the cabinet and including a diaphragm, a voice coil and a magnetic circuit, the diaphragm disposed in the side of the acoustic window and not faced to the acoustic window and having a dome and a suspension surrounding the dome, the dome having a plurality of reinforcements aligned in multi-row, the area of one of the plurality of reinforcements which is closest to the acoustic window that is maximum for improving vibration of the diaphragm.

Abstract: One embodiment of the invention discloses an acoustic device having a housing including a receiving space and a sound hole communicating with the receiving space; a vibration unit received in the receiving space; a magnetic circuit unit driving the vibration unit to vibrate; wherein, the vibration unit includes a first part away from the sound hole and a second part close to the sound hole; and the first part is driven by a higher magnetic force generated by the magnetic circuit unit than the second part.

Abstract: One embodiment of the invention discloses an acoustic device having a housing with a sound hole formed thereon and a speaker unit accommodated in the housing. The speaker unit has a central part, an edge part surrounding the central part and a first strength means formed on the central part for reinforcing rigidity thereof. The first strength means has a first section away from the sound hole and a second section close to the sound hole, and a rigidity of the first section is less than that of the second section.

Abstract: An electro-acoustic device is provided, including a frame; a magnetic circuit received in the frame and including a lower plate fixed on a bottom of the frame and a magnet attached on the lower plate; a vibration system received in the frame and including a vibrating diaphragm attached to a top of the frame; a cavity formed cooperatively by the lower plate, the frame and the vibrating diaphragm; a leak hole provided between the frame and the lower plate for communicating with outside of the electro-acoustic device; and a damper attached to the lower plate and located inside of the electro-acoustic device for covering the leak hole internally.

Abstract: The present disclosure discloses a speaker box. The speaker box includes a housing which has a receiving space and a side wall having a sound hole, and a sound generator received in the receiving space and including a diaphragm including a dome and a periphery connected to the dome. The periphery includes a near-end which is near the sounding hole and a far-end which is farther the sounding hole. A width of the near-end of the periphery perpendicular to a vibration direction of the diaphragm is smaller than a width of the far-end of the periphery perpendicular to the vibration direction.

Abstract: An electro-acoustic device is disclosed. The electro-acoustic device includes a frame; a magnetic circuit received in the frame and including a lower plate fixed on a bottom of the frame and a magnet attached on the lower plate; a vibration system received in the frame and including a vibrating diaphragm attached to a top of the frame; a cavity formed cooperatively by the lower plate, the frame and the vibrating diaphragm; a leak hole provided between the frame and the lower plate for communicating with outside of the electro-acoustic device; and a damper attached to the lower plate and located inside of the electro-acoustic device for covering the leak hole internally.

Abstract: One embodiment of the invention discloses an acoustic device having a housing having an accommodating space with a sound hole formed thereon and communicating with the accommodating space; a speaker unit received in the accommodating space having a diaphragm including a first area away from the sound hole and a second area close to the through window; wherein, the diaphragm has a plurality of corrugations formed on the first area and the second area, respectively, and the amount of the corrugations on the first area is less than that on the second area.

Abstract: A miniature speaker is disclosed. The miniature speaker includes a frame providing a receiving space, a magnetic circuit accommodated in the receiving space, a voice coil, a membrane activated by the voice coil for generating sounds, a number of contacts for electrically connected to the voice coil, and a front cover for fixing the membrane to the frame. The front cover includes an outer ring and a top cover coupled with the outer ring. The top cover includes a step engaging with the outer ring. By virtue of the configuration of the front cover, the assembling precision of the outer ring and the top cover is ensured, and the thicknesses of the outer ring and the top cover are maintained for providing sufficient strength.

Abstract: One embodiment of the invention discloses an acoustic device having a housing with a sound hole formed thereon and a speaker unit accommodated in the housing. The speaker unit has a central part, an edge part surrounding the central part and a first strength means formed on the central part for reinforcing rigidity thereof. The first strength means has a first section away from the sound hole and a second section close to the sound hole, and a rigidity of the first section is less than that of the second section.

Abstract: The present disclosure discloses a speaker box. The speaker box includes a housing which has a receiving space and a side wall having a sound hole, and a sound generator received in the receiving space and including a diaphragm including a dome and a periphery connected to the dome. The periphery includes a near-end which is near the sounding hole and a far-end which is farther the sounding hole. A width of the near-end of the periphery perpendicular to a vibration direction of the diaphragm is smaller than a width of the far-end of the periphery perpendicular to the vibration direction.

Abstract: A speaker box with side acoustic emission structure is disclosed. The speaker box has a case having an acoustic window, a speaker unit mounted in the case and including a diaphragm, a voice coil and a magnetic circuit, the diaphragm disposed in the side of the acoustic window and not faced to the acoustic window and having a dome and a suspension surrounding the dome, the suspension comprising a first end close to the acoustic window and a second end away from the acoustic window, and the first end is lower than the second end along the vibrating direction.

Abstract: One embodiment of the invention discloses an acoustic device having a housing including a receiving space and a sound hole communicating with the receiving space; a vibration unit received in the receiving space; a magnetic circuit unit driving the vibration unit to vibrate; wherein, the vibration unit includes a first part away from the sound hole and a second part close to the sound hole; and the first part is driven by a higher magnetic force generated by the magnetic circuit unit than the second part.

Abstract: The present disclosure discloses a speaker box. The speaker box includes a housing which has a receiving space and a side wall having a sound hole, and a sound generator received in the receiving space and including a diaphragm including a dome and a periphery connected to the dome. The periphery includes a near-end which is near the sounding hole and a far-end which is farther the sounding hole. A compliance of the near-end is less than a compliance of the far-end.

Abstract: A speaker box is disclosed in the present disclosure. The speaker box includes a housing having a receiving space and a sidewall provided with a sound output hole communicating with the receiving space for outputting sounds, and a sound generator received in the housing. The sound generator includes a magnetic circuit system provided with a near end close to the sound output hole and a far end away from the sound output hole, the magnetic field strength of the far end being greater than the magnetic field strength of the near end.

Abstract: One embodiment of the invention discloses an acoustic device having a housing having an accommodating space with a sound hole formed thereon and communicating with the accommodating space; a speaker unit received in the accommodating space having a diaphragm including a first area away from the sound hole and a second area close to the through window; wherein, the diaphragm has a plurality of corrugations formed on the first area and the second area, respectively, and the amount of the corrugations on the first area is less than that on the second area.