Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula (I): wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: An active kitchen safety monitoring system includes a fire prevention alarm device, a gas safety valve, a multifunctional gateway, a server and a user terminal. The fire prevention alarm device sends temperature data of multiple locations on the kitchen stove and kitchen stove usage safety alarm information, both of which are monitored in real time, to the multifunctional gateway. The gas safety valve sends internal pressure data of the gas pipeline, working state information of the motor valve and gas usage safety alarm information to the multifunctional gateway. The multifunctional gateway sends all of the received data to the user terminal through the server, receives and executes operation instructions from the user terminal. The server stores various data and transmits the operation instructions. Through the user terminal, the user is able to view data information and control the gas safety valve and the multifunctional gateway.

Abstract: An active kitchen safety monitoring system includes a fire prevention alarm device, a gas safety valve, a multifunctional gateway, a server and a user terminal. The fire prevention alarm device sends temperature data of multiple locations on the kitchen stove and kitchen stove usage safety alarm information, both of which are monitored in real time, to the multifunctional gateway. The gas safety valve sends internal pressure data of the gas pipeline, working state information of the motor valve and gas usage safety alarm information to the multifunctional gateway. The multifunctional gateway sends all of the received data to the user terminal through the server, receives and executes operation instructions from the user terminal. The server stores various data and transmits the operation instructions. Through the user terminal, the user is able to view data information and control the gas safety valve and the multifunctional gateway.

Abstract: The present application relates to ultrasonic technology, and discloses an ultrasonic beer bubbling container with a good bubble foaming effect and less energy loss. The ultrasonic beer bubbling container comprises a cup body for containing beer and a base provided on the bottom of the cup body. The cup body and the base are separable; an ultrasonic vibrator is arranged in the base, and a through-hole is formed on the bottom of the cup body; wherein a part of the ultrasonic vibrator goes through the through-hole and extends to the cup body, thus to produce ultrasound and directly vibrate the beer so as to foam the beer.