Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: Provided is a method for purifying an anti-4-1BB/anti-HER2 bispecific antibody, the method of which includes carrying out affinity chromatography with a sodium acetate buffer containing a certain inorganic salt as an elution buffer. The purification method of the presently claimed subject matter increases the elution of an antibody in the intact form, thereby being able to provide an anti-4-1BB/anti-HER2 bispecific antibody in the intact form in high purity and high yield.

Abstract: An apparatus for estimating a state of a battery includes a memory configured to store a program of a neural network including a plurality of pre-trained predictive models and an adaptive hidden layer; and includes at least one processor configured to execute the program. The program includes an instruction for receiving battery data of a target battery, inputting the battery data to the adaptive hidden layer, selecting one predictive model from the plurality of pre-trained predictive models through the adaptive hidden layer, inputting the battery data to the selected predictive model, and outputting prediction data for a remaining useful life of the target battery through the selected predictive model.

Abstract: The present exemplary embodiments disclose a redox flow battery. The present exemplary embodiments disclose a redox flow battery which forms a mixing space for mixing an active material in a porous electrode to improve a ununiform concentration of the active material, thereby improving an energy efficiency by reducing an over-potential and increasing an area of the stack and an output thereof.

Abstract: The present exemplary embodiments disclose a redox flow battery. The present exemplary embodiments disclose a redox flow battery which forms a mixing space for mixing an active material in a porous electrode to improve a ununiform concentration of the active material, thereby improving an energy efficiency by reducing an over-potential and increasing an area of the stack and an output thereof.

Abstract: A method of measuring blood pressure, including: sensing an atmospheric pressure, an applied pressure, and a blood pressure of a blood vessel delivered to a skin and outputting an electrical signal indicating a result of sensing the pressures; dividing the electrical signal into a divided electrical signal which includes a direct current (DC) signal and an alternating current (AC) signal; processing the divided electrical signal; calculating the applied pressure using the processed electrical signal; and calculating a blood pressure average using the calculated applied pressure and a swing value of the processed electrical signal.

Abstract: A method of measuring blood pressure, including: sensing an atmospheric pressure, an applied pressure, and a blood pressure of a blood vessel delivered to a skin and outputting an electrical signal indicating a result of sensing the pressures; dividing the electrical signal into a divided electrical signal which includes a direct current (DC) signal and an alternating current (AC) signal; processing the divided electrical signal; calculating the applied pressure using the processed electrical signal; and calculating a blood pressure average using the calculated applied pressure and a swing value of the processed electrical signal.

Abstract: According to an aspect of the present invention, there is provided a blood pressure measuring apparatus including a pressure sensor unit configured to sense an atmospheric pressure, an applied pressure, and a blood pressure of a blood vessel delivered to a skin and output an electrical signal indicating a result of sensing the pressures, while in contact with the skin; a signal division unit configured to receive the electrical signal and divide the electrical signal into a divided electrical signal which includes a direct current (DC) signal and an alternating current (AC) signal; a signal processor unit configured to process the divided electrical signal; and a blood pressure calculation unit configured to calculate the applied pressure using the processed electrical signal and calculate a blood pressure average using the calculated applied pressure and a swing value of the electrical.

Abstract: According to an aspect of the present invention, there is provided a blood pressure measuring apparatus including a pressure sensor unit configured to sense an atmospheric pressure, an applied pressure, and a blood pressure of a blood vessel delivered to a skin and output an electrical signal indicating a result of sensing the pressures, while in contact with the skin; a signal division unit configured to receive the electrical signal and divide the electrical signal into a divided electrical signal which includes a direct current (DC) signal and an alternating current (AC) signal; a signal processor unit configured to process the divided electrical signal; and a blood pressure calculation unit configured to calculate the applied pressure using the processed electrical signal and calculate a blood pressure average using the calculated applied pressure and a swing value of the electrical.

Abstract: An apparatus for sensing a touch which can determine a touch and touch sensitivity thereof in a capacitance-type touch panel. The apparatus for sensing a touch includes a first amplifier having first and second input terminals for outputting a difference of a first input voltage being applied to the first input terminal and a second input voltage being applied to the second input terminal, a second amplifier for amplifying and outputting the difference from the first amplifier, a converting unit for converting an output from the second amplifier into a digital signal and outputting the digital signal, and a control unit for interpreting an output from the converting unit to output a control signal for adjusting impedance of the second input terminal.

Abstract: An apparatus and method for frequency synthesis using a Delay Locked Loop (DLL) are provided. The apparatus includes the DLL, an edge pulse generator, and an inductive-capacitive (LC) tank switch. If phases of a reference frequency signal and a feedback signal are the same and thus are locked, the DLL delays the reference frequency signal. The edge pulse generator generates a plurality of pulse signals representing phase delay amounts of signals. The LC tank switch combines the plurality of pulse signals and generates frequency.

Abstract: Provided are a receiving circuit including a balun circuit and a notch filter, and an operating method thereof. The receiving circuit includes a transformer, a notch filter, and a mixer. The transformer converts a single input signal to a differential input signal using a first tap. The notch filter blocks a specific frequency band of the single input signal by connecting a second tap with the first tap of the transformer using a condenser.

Abstract: An apparatus and a method for calibrating a Voltage Controlled Oscillator (VCO) using a fast frequency comparison based on phase manipulation are provided. The calibrating apparatus includes a phase shifter for comparing an input reference frequency and an input divided frequency and shifting a phase of the reference frequency to make the phase of the reference frequency align with a phase of the divided frequency; a frequency comparator for determining which one of the phase-shifted reference frequency and the divided frequency is higher; and a cap-bank control for determining a frequency to use based on a comparison result of the frequency comparator.

Abstract: Provided are a receiving circuit including a balun circuit and a notch filter, and an operating method thereof. The receiving circuit includes a transformer, a notch filter, and a mixer. The transformer converts a single input signal to a differential input signal using a first tap. The notch filter blocks a specific frequency band of the single input signal by connecting a second tap with the first tap of the transformer using a condenser.

Abstract: The present invention relates to an oxygen isotope separation system and a method therefor. More specifically, the invention relates to a newly invented pressure-driven AGMD (Air Gap Membrane Distillation) system applied to a multi-stage membrane distillation cells which can produce an oxygen isotope effectively and economically, and a method therefor. The invention provides an oxygen isotope separation system including a number of Air Gap Membrane Distillation (AGMD) permeation cells connected in series to separate a feed into a product and a tail, wherein each of the AGMD cell is connected at a tail outlet with a reflux pump and at a product outlet, whereby the product from (i?1)th cell and the tail from (i+1)th cell are pumped as the feed into ith cell.

Abstract: An apparatus and method for frequency synthesis using a Delay Locked Loop (DLL) are provided. The apparatus includes the DLL, an edge pulse generator, and an inductive-capacitive (LC) tank switch. If phases of a reference frequency signal and a feedback signal are the same and thus are locked, the DLL delays the reference frequency signal. The edge pulse generator generates a plurality of pulse signals representing phase delay amounts of signals. The LC tank switch combines the plurality of pulse signals and generates frequency.

Abstract: The present invention relates to an oxygen isotope separation system and a method therefor. More specifically, the invention relates to a newly invented pressure-driven AGMD (Air Gap Membrane Distillation) system applied to a multi-stage membrane distillation cells which can produce an oxygen isotope effectively and economically, and a method therefor. The invention provides an oxygen isotope separation system including a number of Air Gap Membrane Distillation (AGMD) permeation cells connected in series to separate a feed into a product and a tail, wherein each of the AGMD cell is connected at a tail outlet with a reflux pump and at a product outlet, whereby the product from (i?1)th cell and the tail from (i+1)th cell are pumped as the feed into ith cell.

Abstract: A PLL can operate linearly at various frequencies by overlapping several VCOs and using a control circuit for controlling the several VCOs to select a VCO at a desired frequency. Accordingly, the PLL can automatically pre-compensate the frequency by using a control signal used in the PLL. As a result, a separate frequency compensation signal is not required. The PLL can be configure on a single chip when the VCO is contained within the PLL.

Abstract: A disclosed PLL can operate linearly at various frequencies by overlapping several VCOs and using a control circuit for controlling the several VCOs to select a VCO at a desired frequency. Accordingly, since the disclosed PLL can automatically pre-compensate the frequency by using control signal used in the PLL, a separate frequency correcting signal is not required. When containing a VCO, the disclosed PLL can be configured into a single chip.