Patents by Inventor Yunyu Mao

Yunyu Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of pegylated drug-linkers and intermediates thereof
    Patent number: 11844839
    Abstract: The present invention provides improved processes for the preparation of auristatin drug-linkers with a PEG unit, as well as intermediates thereof.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: December 19, 2023
    Assignee: Seagen Inc.
    Inventors: Yunyu Mao, Philip Moquist, Anusuya Choudhury, Wendel Doubleday
  • Process for the preparation of glucuronide drug-linkers and intermediates thereof
    Patent number: 11730822
    Abstract: The present invention provides improved processes for the preparation of drug-linkers with a ?-glucuronide cleavable unit, as well as intermediates thereof.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: August 22, 2023
    Assignee: Seagen Inc.
    Inventors: Yunyu Mao, Philip Moquist, Anusuya Choudhury, Wendel Doubleday
  • PROCESS FOR THE PREPARATION OF GLUCURONIDE DRUG-LINKERS AND INTERMEDIATES THEREOF
    Publication number: 20200222553
    Abstract: The present invention provides improved processes for the preparation of drug-linkers with a ?-glucuronide cleavable unit, as well as intermediates thereof.
    Type: Application
    Filed: March 23, 2018
    Publication date: July 16, 2020
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Yunyu Mao, Philip Moquist, Anusuya Choudhury, Wendel Doubleday
  • PROCESS FOR THE PREPARATION OF PEGYLATED DRUG-LINKERS AND INTERMEDIATES THEREOF
    Publication number: 20190388546
    Abstract: The present invention provides improved processes for the preparation of auristatin drug-linkers with a PEG unit, as well as intermediates thereof.
    Type: Application
    Filed: March 24, 2017
    Publication date: December 26, 2019
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Yunyu Mao, Philip Moquist, Anusuya Choudhury, Wendel Doubleday
  • PREPARATION OF C-PYRAZINE-METHYLAMINES
    Publication number: 20130261306
    Abstract: A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis.
    Type: Application
    Filed: May 23, 2013
    Publication date: October 3, 2013
    Applicant: OSI Pharmaceuticals, LLC
    Inventors: Yunyu Mao, Kristen Michelle Mulvihill, Josef A. Rechka, Paula A. Tavares-Greco
  • Preparation of -pyrazine-methylamines
    Patent number: 8513415
    Abstract: A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 20, 2013
    Assignee: OSI Pharmaceuticals, LLC
    Inventors: Yunyu Mao, Josef A. Rechka, Paula A. Tavares-Greco
  • PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES
    Publication number: 20120108812
    Abstract: Processes including preparation of trans-4-[(3-amino-5-oxo-4,5-dihydro-[1,2,4]triazin-6-ylmethyl)-carbamoyl]-cyclohexanecarboxylic acid methyl ester, and its conversion to trans-4-(4-amino-5-substituted-imidazo[5,1-f][1,2,4]triazin-7-yl)-cyclohexanecarboxylic acid compounds.
    Type: Application
    Filed: July 8, 2010
    Publication date: May 3, 2012
    Inventors: Hanqing Dong, Yunyu Mao, Kristen Michelle Mulvhill, Josef A. Rechka, Douglas S. Werner
  • Preparation of C-Pyrazine-Methylamines
    Publication number: 20120041202
    Abstract: A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis.
    Type: Application
    Filed: April 19, 2010
    Publication date: February 16, 2012
    Inventors: Yunyu Mao, Kristen Michelle Mulvihill, Josef A. Rechka, Paula A. Tavares-Greco