Patents by Inventor Yupeng Fan

Yupeng Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110250138
    Abstract: The invention provides modified oligonucleotides of formula (I), comprising at least one metal chelator which provides a powerful tool for study of the pharmacokinetics of siRNA and its correlation with in vivo activity. The chelated metals provide luminescent properties enable detection of the oligonucleotides through the use of time-resolved fluorescent quenching based on energy transfer from the metal ion to a nonfluorescent quencher which can be used as non-isotopic labels of oligonucleotides for diagnostics and evaluation of cellular uptake.
    Type: Application
    Filed: July 30, 2008
    Publication date: October 13, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Yupeng Fan, Martin Maier, Rajendra K. Pandey, Muthiah Manoharan, Kallanthottathil G. Rajeev