Abstract: A display substrate and a display device are provided. The display substrate includes a base substrate, a pixel circuit layer and an anode layer; the pixel circuit layer includes a plurality of pixel driving circuits, the anode layer includes a plurality of anode groups, each of the plurality of anode groups includes a first anode and a second anode which are oppositely arranged, the first anode includes a first main body portion and a first connection portion, the first anode further includes an extension portion and an anode compensation portion, an orthographic projection of the anode compensation portion on the base substrate covers one thin film transistor in the pixel driving circuit connected to the first connection portion.

Abstract: Disclosed herein are methods for isolating DNA, such as cell-free DNA (cfDNA) or DNA from a tissue sample, e.g., in which the DNA is partitioned into hypermethylated and hypomethylated partitions. After differential tagging of the partitions, portions of the hypomethylated partition are pooled with the hypermethylated partition or pooled separately. Epigenetic and sequence-variable target regions are captured from the pool comprising DNA from the hypermethylated and hypomethylated partitions, and sequence-variable target regions are captured from the pool comprising DNA from the hypomethylated partition. This approach can reduce costs and/or bandwidth by limiting sequencing of epigenetic target regions from the hypomethylated partition, which may be less informative than other DNA.

Abstract: In an aspect, a method for detecting the presence or absence of cancer in a subject comprises: (a) obtaining samples from the subject from different time points, wherein a first sample obtained at first time point is a polynucleotide sample from a tumor tissue specimen and a second sample obtained at second time point is a cell-free polynucleotide sample from a blood sample; (b) processing polynucleotides from each of the samples, comprising: i) tagging at least a portion of the polynucleotides, thereby generating tagged parent polynucleotides; ii) amplifying at least a portion of the tagged parent polynucleotides to generate progeny polynucleotides; iii) enriching at least a portion of the progeny polynucleotides for target genomic regions; thereby generating enriched polynucleotides; and iv) sequencing at least a portion of the enriched polynucleotides to generate sequencing reads; and (c) analyzing genomic regions for at least one epigenetic feature from the sequencing reads.

Abstract: A display substrate, a manufacturing method thereof, and a display device are provided. A pixel region is provided with a light emission function layer on a base substrate of the display substrate, and a separation region is provided with at least one first barrier structure. The first barrier structure includes a stopper pattern and a first separation component. A side surface of the first separation component has a recess, and a portion of the light emission function layer extending to the separation region is disconnected on the side of the first separation component. The separation region is provided with an inorganic layer structure on the base substrate. The inorganic layer structure includes multiple stacked inorganic film layers, the stopper pattern is located between two adjacent inorganic film layers and the first separation component is located on a side of the inorganic layer structure away from the base substrate.

Abstract: A display substrate and a display device. The display substrate includes a base substrate and a plurality of sub-pixels on the base substrate. Each sub-pixels includes a pixel circuit. The plurality of sub-pixels include a first sub-pixel. The compensation sub-circuit of the first sub-pixel includes a first electrode, a second electrode, and a connection portion between the first electrode and the second electrode. The first drive electrode of the light-emitting element of the first sub-pixel includes a first main body portion including a first side parallel to a certain direction, and a first protruding portion protruding from the first side of the first main body portion. The first protruding portion at least partially overlaps with the connection portion of the compensation sub-circuit of the first sub-pixel in a direction perpendicular to the base substrate. The light-emitting element of the first sub-pixel is configured to emit green light.

Abstract: A display substrate and a display device are provided. In the display substrate, each of the plurality of anode groups includes a first anode and a second anode, the first anode includes a first main body portion, a first connection portion, an extension portion and an anode compensation portion, an orthographic projection of the anode compensation portion on the base substrate covers one thin film transistor, the anode compensation portion has a first point at a side away from the second center line, and the first main body portion has a second point at the first side, the first anode and a connection line between the first point and the second point enclose a notch region, and an area of the notch region is greater than at least one of an area of the anode compensation portion and an area of the first connection portion.

Abstract: A display panel, crack detection method therefor, and display device. The display panel comprises a display area (100) provided with at least one first data line (101) and at least one second data line (102), and peripheral area (200) surrounding the display area and provided with a first crack detection line, second crack detection line, first detection switch circuit (51), and second detection switch circuit (52); the first crack detection line and second crack detection line are in different functional layers; the first crack detection line has a first end (A) electrically connected to a first test end and a second end (C) electrically connected to first detection switch circuit; the second crack detection line has a first end (B1) electrically connected to a third node (B) that is different from the first end (A) and second end (C), and a second end (A1) electrically connected to second detection switch circuit.

Abstract: In an aspect, a method for detecting the presence or absence of cancer in a subject comprises: (a) obtaining samples from the subject from different time points, wherein a first sample obtained at first time point is a polynucleotide sample from a tumor tissue specimen and a second sample obtained at second time point is a cell-free polynucleotide sample from a blood sample; (b) processing polynucleotides from each of the samples, comprising: i) tagging at least a portion of the polynucleotides, thereby generating tagged parent polynucleotides; ii) amplifying at least a portion of the tagged parent polynucleotides to generate progeny polynucleotides; iii) enriching at least a portion of the progeny polynucleotides for target genomic regions; thereby generating enriched polynucleotides; and iv) sequencing at least a portion of the enriched polynucleotides to generate sequencing reads; and (c) analyzing genomic regions for at least one epigenetic feature from the sequencing reads.

Abstract: A display substrate, a manufacturing method thereof, and a display device are provided. A pixel region is provided with a light emission function layer on a base substrate of the display substrate, and a separation region is provided with at least one first barrier structure. The first barrier structure includes a stopper pattern and a first separation component. A side surface of the first separation component has a recess, and a portion of the light emission function layer extending to the separation region is disconnected on the side of the first separation component. The separation region is provided with an inorganic layer structure on the base substrate. The inorganic layer structure includes multiple stacked inorganic film layers, the stopper pattern is located between two adjacent inorganic film layers and the first separation component is located on a side of the inorganic layer structure away from the base substrate.

Abstract: A display substrate and a display device. The display substrate includes a base substrate and a plurality of sub-pixels on the base substrate. Each sub-pixels includes a pixel circuit. The plurality of sub-pixels include a first sub-pixel. The compensation sub-circuit of the first sub-pixel includes a first electrode, a second electrode, and a connection portion between the first electrode and the second electrode. The first drive electrode of the light-emitting element of the first sub-pixel includes a first main body portion including a first side parallel to a certain direction, and a first protruding portion protruding from the first side of the first main body portion. The first protruding portion at least partially overlaps with the connection portion of the compensation sub-circuit of the first sub-pixel in a direction perpendicular to the base substrate. The light-emitting element of the first sub-pixel is configured to emit green light.

Abstract: A display substrate and an electronic device are provided. The display substrate includes a base substrate, including a display region and a peripheral region on at least one side of the display region; and a shift register unit and a first clock signal line in the peripheral region of the base substrate, wherein the first clock signal line extends along a first direction on the base substrate, and is connected to a first clock signal terminal to be configured to provide a first clock signal to the shift register unit; the shift register unit includes an input circuit, an output circuit, a first control circuit, and an output control circuit; the output control circuit includes an output control transistor and a first capacitor, and the output circuit includes an output transistor and a second capacitor.

Abstract: A display substrate and a display device are provided. The display substrate includes a base substrate, and a shift register unit, a first clock signal line, and a second clock signal line that are provided on the base substrate. The shift register unit includes an input circuit, an output circuit, a first control circuit, a second control circuit, and an output control circuit, and the second control circuit includes a first noise reduction transistor and a second noise reduction transistor; and the input circuit includes an input transistor, the input transistor and the first noise reduction transistor are sequentially arranged in the first direction, and an imaginary line of a channel region of the first noise reduction transistor extending in the second direction does not intersect with an imaginary line of an active layer of the input transistor extending in the second direction.

Abstract: Provided is a display substrate. The display substrate includes: a base substrate, a plurality of sub-pixels, a plurality of data lines, a plurality of data transmission lines, a plurality of electrostatic discharge circuits, a panel crack detection trace, and a plurality of electrostatic discharge dummy circuits. At least one of the electrostatic discharge dummy circuits may be connected to the panel crack detection trace. A display device is also provided.

Abstract: A display substrate and manufacturing method thereof, and a display device are provided. The display substrate includes a base substrate, and a shift register unit and a first clock signal line that are on the base substrate, the first clock signal line extends along a first direction on the base substrate, the shift register unit includes an input circuit, an output circuit, a first control circuit, a second control circuit, and an output control circuit; and an orthographic projection of the intermediate transfer electrode on the base substrate is between a whole of an orthographic projection of the active layer of the first control transistor on the base substrate and an orthographic projection of the second control transistor on the base substrate and orthographic projections of the active layers of the first noise reduction transistor and the second noise reduction transistor on the base substrate.

Abstract: A pixel circuit, a display substrate and a display device are disclosed. The pixel circuit includes: a threshold compensation transistor, a shielding element including a first shielding portion and a second shielding portion coupled with each other; a data writing transistor, orthographic projections of an active layer of the data writing transistor and the gate of the data writing transistor on the substrate are overlapped to form a first overlapping area; the first electrode and the active layer of the data writing transistor are in a same layer, orthographic projections of the first electrode of the data writing transistor and the second shielding portion on the substrate are overlapped to form a second overlapping area; a size of the second overlapping area in the first direction is smaller than that of the first overlapping area in the first direction.

Abstract: A display panel and a display apparatus. The display panel includes a base layer, a pixel defining layer, red pixels, green pixels, blue pixels, and spacers. The pixel defining layer is on the base layer. The pixel defining layer is formed with a plurality of openings. The red pixels, the green pixels, and the blue pixels are on the base layer. The red pixels, the green pixels, and the blue pixels each are corresponding to one of the openings. The spacers are on the pixel defining layer. The spacers each are between the green pixel and blue pixel adjacent to each other.

Abstract: A display substrate and a display panel are disclosed. The display substrate includes a base substrate having an active area and a peripheral area surrounding the active area; a plurality of sub-pixels, in the active area; a plurality of first pins and a plurality of second pins located in the peripheral area; a plurality of first array test pins located between the plurality of first pins and the plurality of second pins and respectively electrically coupled to a plurality of array test signal lines; and a plurality of second array test pins located between the plurality of first pins and the plurality of second pins and extending in a direction along a boundary of the active area, wherein the plurality of first array test pins are located on at least one side of the plurality of second array test pins in the direction along the boundary of the active area.

Abstract: A display substrate has at least two wiring areas, a hole border area surrounding the wiring areas, a display area surrounding the hole border area, at least one through hole area, at least one blind hole area. The blind hole area is light-transmitting. Each through hole area and each blind hole area are both surrounded by a respective wiring area. The display substrate includes a base substrate having a through hole in each through hole area, and a driver circuit layer which includes at least one metal layer located in the display area and the wiring areas, and at least one insulating layer located In the display area, the hold border area, the wiring areas, and the at least one blind hole area. The metal layer Includes a plurality of signal lines arranged to avoid the at least one through hole area and the at least one blind hole area.

Abstract: A display panel, crack detection method therefor, and display device. The display panel comprises a display area (100) provided with at least one first data line (101) and at least one second data line (102), and peripheral area (200) surrounding the display area and provided with a first crack detection line, second crack detection line, first detection switch circuit (51), and second detection switch circuit (52); the first crack detection line and second crack detection line are in different functional layers; the first crack detection line has a first end (A) electrically connected to a first test end and a second end (C) electrically connected to first detection switch circuit; the second crack detection line has a first end (B1) electrically connected to a third node (B) that is different from the first end (A) and second end (C), and a second end (A1 electrically connected to second detection switch circuit.

Abstract: A display panel and a display device are provided. The display panel includes: a sub-pixel including a pixel circuit and a light-emitting element, the light-emitting element including a first electrode; a first insulating layer, the first electrode being connected with the pixel circuit through a first via hole penetrating the first insulating layer; a pixel definition layer including an opening; the first electrode includes a main body portion and a connecting portion, the main body portion is at least partially overlapped with the opening, the connecting portion is at least partially overlapped with the first via hole, a size of the connecting portion at the first via hole in a first direction is ? to ? of a size of the main body portion in the first direction.