Patents by Inventor Yuping He

Yuping He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10800734
    Abstract: Provided are compounds of formula (I), or a stereoisomer, mixture of stereoisomers, deuterated analog, tautomer, solvate or pharmaceutically acceptable salt thereof, compositions, method of making and uses thereof.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: October 13, 2020
    Assignee: Sunshine Lake Pharma Co., Ltd.
    Inventors: Bifei He, Yuping Fan, Huixiong Lu, Guangyuan Liu, Zhongqing Wang, Zhonghua Luo
  • Patent number: 10803013
    Abstract: A software application platform for uploading a file to a server is disclosed. The server receives a request from a user to upload a file thereto. An upload client extracts file information from the file. The server generates a file signature for the file. The server accesses one or more existing file signatures for each of one or more existing files on the server. The server determines whether any of the one or more existing file signatures are similar to the file signature. Responsive to determining that there is an existing file signature that is similar to the file signature, the server accesses a first hash signature for the existing file. The upload client generates a second hash signature for the file. Responsive to determining that the first hash signature does not equal the second hash signature, the upload client uploads the file to the server.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: October 13, 2020
    Assignee: SMUGMUG, INC.
    Inventors: Gabrielle Burns, Yuping He
  • Patent number: 10744318
    Abstract: Disclosed herein are current output architectures for implantable stimulator devices. Current source and sink circuitry is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking an amount of current to or from any one of the electrodes of the device. The current source circuitry is distinct from the current sink circuitry, and the two share no common circuit nodes prior to connection to the electrodes. In other words, the current source circuitry and the current sink circuitry do not share a common node other than the electrodes. Each stage is preferably formed of a current mirror for receiving a reference current and outputting a scaled version of current to that stage's switch bank. The scalar at each stage can be set by wiring a desired number of output transistors in parallel.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 18, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Yuping He, David K. L. Peterson
  • Patent number: 10654797
    Abstract: Provided herein are crystalline forms of (((((1r, 3R, 5S, 7r)-3, 5-dimethyladamantan-1-yl)carbamoyl) oxy) methyl benzoate (Compound (I)): Also provided are compositions comprising the crystalline forms of Compound (I), processes of manufacture and methods of using the crystalline forms of Compound (I).
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: May 19, 2020
    Assignee: North & South Brother Pharmacy Investment Company Limited
    Inventors: Huiqing Ye, Jinchao Xu, Bifei He, Guangyuan Liu, Yuping Fan, Zhongqing Wang, Zhonghua Luo
  • Publication number: 20200086125
    Abstract: Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 19, 2020
    Inventors: Jordi Parramon, Kiran Nimmagadda, Emanuel Feldman, Yuping He
  • Patent number: 10518091
    Abstract: Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: December 31, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Jordi Parramon, Kiran Nimmagadda, Emanuel Feldman, Yuping He
  • Publication number: 20190315679
    Abstract: Provided herein are crystalline forms of (((((1r, 3R, 5S, 7r)-3, 5-dimethyladamantan-1-yl)carbamoyl) oxy) methyl benzoate (Compound (I)): Also provided are compositions comprising the crystalline forms of Compound (I), processes of manufacture and methods of using the crystalline forms of Compound (I).
    Type: Application
    Filed: November 2, 2017
    Publication date: October 17, 2019
    Inventors: Huiqing Ye, Jinchao Xu, Bifei He, Guangyuan Liu, Yuping Fan, Zhongqing Wang, Zhonhhua Luo
  • Publication number: 20190144378
    Abstract: Provided are compounds of formula (I), or a stereoisomer, mixture of stereoisomers, deuterated analog, tautomer, solvate or pharmaceutically acceptable salt thereof, compositions, method of making and uses thereof.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 16, 2019
    Inventors: Bifei He, Yuping Fan, Huixiong Lu, Guangyuan Liu, Zhongqing Wang, Zhonghua Luo
  • Publication number: 20190030344
    Abstract: Circuitry useable to protect and reliably charge a rechargeable battery, even from a zero-volt state, is disclosed, and is particularly useful when employed in an implantable medical device. The circuit includes two charging paths, a first path for trickle charging the battery, and a second path for charging the battery at relatively higher currents. A passive diode is used in the first trickle-charging path which allows trickle charging even when the battery voltage is too low for reliable gating, while a gateable switch (preferably a PMOS transistor) is used in the second higher-current charging path when the voltage is higher and the switch can therefore be gated more reliably. A second diode between the two paths ensures no leakage to the substrate through the gateable switch during trickle charging. The load couples to the battery through the switch, and preferably through a second switch specifically used for decoupling the load.
    Type: Application
    Filed: October 1, 2018
    Publication date: January 31, 2019
    Inventors: Yuping He, David K. L. Peterson
  • Patent number: 10118045
    Abstract: Circuitry useable to protect and reliably charge a rechargeable battery, even from a zero-volt state, is disclosed, and is particularly useful when employed in an implantable medical device. The circuit includes two charging paths, a first path for trickle charging the battery at a relatively low current when the battery voltage is below a threshold, and a second path for charging the battery at relatively higher currents that the battery voltage is above a certain threshold. A passive diode is used in the first trickle-charging path which allows trickle charging even when the battery voltage is too low for reliable gating, while a gateable switch (preferably a PMOS transistor) is used in the second higher-current charging path when the voltage is higher and the switch can therefore be gated more reliably. A second diode between the two paths ensures no leakage to the substrate through the gateable switch during trickle charging.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 6, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Yuping He, David K. L. Peterson
  • Publication number: 20180232388
    Abstract: Embodiments disclosed herein generally relate to a method for uploading a file to a server. The server receives a request from a user to upload a file thereto. An upload client extracts file information from the file. The server generates a file signature for the file. The server accesses one or more existing file signatures for each of one or more existing files on the server. The server determines whether any of the one or more existing file signatures are similar to the file signature. Responsive to determining that there is an existing file signature that is similar to the file signature, the server accesses a first hash signature for the existing file. The upload client generates a second hash signature for the file. Responsive to determining that the first hash signature does not equal the second hash signature, the upload client uploads the file to the server.
    Type: Application
    Filed: January 22, 2018
    Publication date: August 16, 2018
    Inventors: Gabrielle BURNS, Yuping HE
  • Publication number: 20180178003
    Abstract: Disclosed herein are current output architectures for implantable stimulator devices. Current source and sink circuitry is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking an amount of current to or from any one of the electrodes of the device. The current source circuitry is distinct from the current sink circuitry, and the two share no common circuit nodes prior to connection to the electrodes. In other words, the current source circuitry and the current sink circuitry do not share a common node other than the electrodes. Each stage is preferably formed of a current mirror for receiving a reference current and outputting a scaled version of current to that stage's switch bank. The scalar at each stage can be set by wiring a desired number of output transistors in parallel.
    Type: Application
    Filed: February 23, 2018
    Publication date: June 28, 2018
    Inventors: Yuping He, David K.L. Peterson
  • Publication number: 20180104499
    Abstract: Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 19, 2018
    Inventors: Jordi Parramon, Goran N. Marnfeldt, Robert Ozawa, Emanuel Feldman, Dave Peterson, Yuping He
  • Patent number: 9931502
    Abstract: Disclosed herein are current output architectures for implantable stimulator devices. Current source and sink circuitry is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking an amount of current to or from any one of the electrodes of the device. The current source circuitry is distinct from the current sink circuitry, and the two share no common circuit nodes prior to connection to the electrodes. In other words, the current source circuitry and the current sink circuitry do not share a common node other than the electrodes. Each stage is preferably formed of a current mirror for receiving a reference current and outputting a scaled version of current to that stage's switch bank. The scalar at each stage can be set by wiring a desired number of output transistors in parallel.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: April 3, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Yuping He, David K. L. Peterson
  • Patent number: 9855438
    Abstract: Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: January 2, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Jordi Parramon, Goran N. Marnfeldt, Robert Ozawa, Emanuel Feldman, Dave Peterson, Yuping He
  • Publication number: 20170340886
    Abstract: Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device.
    Type: Application
    Filed: August 11, 2017
    Publication date: November 30, 2017
    Inventors: Jordi Parramon, Kiran Nimmagadda, Emanuel Feldman, Yuping He
  • Publication number: 20170281950
    Abstract: Circuitry useable to protect and reliably charge a rechargeable battery, even from a zero-volt state, is disclosed, and is particularly useful when employed in an implantable medical device. The circuit includes two charging paths, a first path for trickle charging the battery at a relatively low current when the battery voltage is below a threshold, and a second path for charging the battery at relatively higher currents that the battery voltage is above a certain threshold. A passive diode is used in the first trickle-charging path which allows trickle charging even when the battery voltage is too low for reliable gating, while a gateable switch (preferably a PMOS transistor) is used in the second higher-current charging path when the voltage is higher and the switch can therefore be gated more reliably. A second diode between the two paths ensures no leakage to the substrate through the gateable switch during trickle charging.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Inventors: Yuping He, David K. L. Peterson
  • Patent number: 9737713
    Abstract: Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: August 22, 2017
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Jordi Parramon, Kiran Nimmagadda, Emanuel Feldman, Yuping He
  • Patent number: 9687663
    Abstract: Circuitry useable to protect and reliably charge a rechargeable battery, even from a zero-volt state, is disclosed, and is particularly useful when employed in an implantable medical device. The circuit includes two charging paths, a first path for trickle charging the battery at a relatively low current when the battery voltage is below a threshold, and a second path for charging the battery at relatively higher currents that the battery voltage is above a certain threshold. A passive diode is used in the first trickle-charging path which allows trickle charging even when the battery voltage is too low for reliable gating, while a gateable switch (preferably a PMOS transistor) is used in the second higher-current charging path when the voltage is higher and the switch can therefore be gated more reliably. A second diode between the two paths ensures no leakage to the substrate through the gateable switch during trickle charging.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: June 27, 2017
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Yuping He, David K. L. Peterson
  • Publication number: 20160287886
    Abstract: Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 6, 2016
    Inventors: Jordi Parramon, Goran N. Marnfeldt, Robert Ozawa, Emanuel Feldman, Dave Peterson, Yuping He