Abstract: A method of generating a 3D video, a method of training a neural network model, an electronic device, and a storage medium, which relate to a field of image processing, and in particular to technical fields of computer vision, augmented/virtual reality and deep learning. The method includes: determining, based on an input speech feature, a principal component analysis (PCA) coefficient by using a first network, wherein the PCA coefficient is used to generate the 3D video; correcting the PCA coefficient by using a second network; generating a lip movement information based on the corrected PCA coefficient and a PCA parameter for a neural network model, wherein the neural network model includes the first network and the second network; and applying the lip movement information to a pre-constructed 3D basic avatar model to obtain a 3D video with a lip movement effect.

Abstract: A method and system for leakage status evaluation and leaks location of a solid waste land disposal facility. The method includes: arranging an off-site emitting electrode for the solid waste land disposal facility, and arranging a plurality of intra-site receiving electrodes on a solid waste pile surface in a grid shape; selecting a power supply to collect a current value between the off-site emitting electrode and each of the intra-site receiving electrodes respectively, and determining a maximum current value point Mn of the solid waste pile surface and a maximum current value An; selecting an off-site point So2, and measuring a current value between the off-site emitting electrode and the point So2 as a reference current Ab under the same power supply condition; and determining a leakage status of the solid waste land disposal facility based on a ratio of the maximum current value An to the reference current Ab.

Abstract: A method of generating a 3D video, a method of training a neural network model, an electronic device, and a storage medium, which relate to a field of image processing, and in particular to technical fields of computer vision, augmented/virtual reality and deep learning. The method includes: determining, based on an input speech feature, a principal component analysis (PCA) coefficient by using a first network, wherein the PCA coefficient is used to generate the 3D video; correcting the PCA coefficient by using a second network; generating a lip movement information based on the corrected PCA coefficient and a PCA parameter for a neural network model, wherein the neural network model includes the first network and the second network; and applying the lip movement information to a pre-constructed 3D basic avatar model to obtain a 3D video with a lip movement effect.

Abstract: The disclosure provides a method for generating a three-dimensional virtual image. The method includes: obtaining a face image to be processed and a three-dimensional reference model; obtaining a three-dimensional face model, face attribute information and face image information by inputting the face image to be processed into a trained neural network; obtaining a three-dimensional image model by performing a deformation process on the three-dimensional reference model based on the three-dimensional face model; and obtaining a target virtual image by adjusting the three-dimensional image model based on the face attribute information and the face image information.

Abstract: A method and apparatus for predicting a mouth-shape feature, and an electronic device are provided. A specific implementation of the method comprises: recognizing a phonetic posterior gram (PPG) of a phonetic feature; and performing a prediction on the PPG by using a neural network model, to predict a mouth-shape feature of the phonetic feature, the neural network model being obtained by training with training samples and an input thereof including a PPG and an output thereof including a mouth-shape feature, and the training samples including a PPG training sample and a mouth-shape feature training sample.

Abstract: A method and system for leakage status evaluation and leaks location of a solid waste land disposal facility. The method includes: arranging an off-site emitting electrode for the solid waste land disposal facility, and arranging a plurality of intra-site receiving electrodes on a solid waste pile surface in a grid shape; selecting a power supply to collect a current value between the off-site emitting electrode and each of the intra-site receiving electrodes respectively, and determining a maximum current value point Mn of the solid waste pile surface and a maximum current value An; selecting an off-site point So2, and measuring a current value between the off-site emitting electrode and the point So2 as a reference current Ab under the same power supply condition; and determining a leakage status of the solid waste land disposal facility based on a ratio of the maximum current value An to the reference current Ab.

Abstract: The disclosure provides a method for generating a three-dimensional virtual image. The method includes: obtaining a face image to be processed and a three-dimensional reference model; obtaining a three-dimensional face model, face attribute information and face image information by inputting the face image to be processed into a trained neural network; obtaining a three-dimensional image model by performing a deformation process on the three-dimensional reference model based on the three-dimensional face model; and obtaining a target virtual image by adjusting the three-dimensional image model based on the face attribute information and the face image information.

Abstract: The present invention provides a crystal form of urate transporter 1 inhibitor and a preparation method and use thereof. The crystal form is characterized by a stable state of appearance and a capability of further improving the purity and storage stability of the compound, etc., and suitable as a pharmaceutical raw material.

Abstract: A method and apparatus for predicting a mouth-shape feature, and an electronic device are provided. A specific implementation of the method comprises: recognizing a phonetic posterior gram (PPG) of a phonetic feature; and performing a prediction on the PPG by using a neural network model, to predict a mouth-shape feature of the phonetic feature, the neural network model being obtained by training with training samples and an input thereof including a PPG and an output thereof including a mouth-shape feature, and the training samples including a PPG training sample and a mouth-shape feature training sample.

Abstract: Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization.

Abstract: The present invention provides a crystal form of urate transporter 1 inhibitor and a preparation method and use thereof. The crystal form is characterized by a stable state of appearance and a capability of further improving the purity and storage stability of the compound, etc., and suitable as a pharmaceutical raw material.

Abstract: The present invention relates to the pharmaceutical field for the treatment of hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid urate transporter 1 (URAT1) inhibitor of a general formula (I) containing a diarylmethane structure and a preparation method thereof, and a pharmaceutical composition containing the same and a use thereof in the preparation of medicaments for treating hyperuricemia and gout, wherein R1 is selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, F, Cl, Br, I, CN, NO2, SR4 or OR4; R2 is selected from H, F, Cl, Br or I; R3 is selected from H or C1-C4 alkyl; X is selected from S or CH2; wherein R4 is selected from C1-C10 alkyl.

Abstract: Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization.

Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.

Abstract: The present invention relates to the pharmaceutical field for the treatment of hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid urate transporter 1 (URAT1) inhibitor of a general formula (I) containing a diarylmethane structure and a preparation method thereof, and a pharmaceutical composition containing the same and a use thereof in the preparation of medicaments for treating hyperuricemia and gout, wherein R1 is selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, F, Cl, Br, I, CN, NO2, SR4 or OR4; R2 is selected from H, F, Cl, Br or I; R3 is selected from H or C1-C4 alkyl; X is selected from S or CH2; wherein R4 is selected from C1-C10 alkyl.

Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.

Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.

Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.