Patents by Inventor Yuqiao Shen

Yuqiao Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oncolytic adenovirus
    Publication number: 20040151696
    Abstract: Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 5, 2004
    Inventors: Leisa Johnson, Ali Fattaey, Terry Hermiston, Yuqiao Shen, Sylvie Laquerre
  • Adenovirus E1B-55K single amino acid mutants and methods of use
    Patent number: 6635244
    Abstract: Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: October 21, 2003
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: Yuqiao Shen, Julie Nye, Terry Hermiston
  • Viral mutants that selectively replicate in targeted human cancer cells
    Publication number: 20030021768
    Abstract: Oncolytic viruses are described that have favorable anti-cancer activity and that are produced by random mutagenesis and subsequent bio-selection on cancer cells wherein the viruses are preferably adenoviruses having at least one mutation in the i-leader sequence of the viral major late transcriptional unit.
    Type: Application
    Filed: July 9, 2002
    Publication date: January 30, 2003
    Inventors: Yuqiao Shen, Terry Hermiston, Ali Fattaey
  • Adenovirus E1B-55K single amino acid mutants and methods of use
    Publication number: 20030003076
    Abstract: Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.
    Type: Application
    Filed: July 30, 2001
    Publication date: January 2, 2003
    Inventors: Yuqiao Shen, Julie Nye, Terry Hermiston