Abstract: A graft copolymer and a preparation method and use thereof. The method for preparing a graft copolymer includes: dissolving an N-ethyl-2-pyrrolidinone-substituted flavan-3-ol (EPSF) and a starch in a polar organic solvent, to obtain a raw material solution; and mixing the raw material solution with ascorbic acid and hydrogen peroxide to obtain a mixture, and subjecting the mixture to a grafting reaction, to obtain the graft copolymer.

Abstract: The present disclosure belongs to the technical field of waterproofing, and relates to a waterproof membrane, a preparation method and a construction method thereof, and a tunnel waterproof system. The waterproof membrane includes a resin sheet layer, a non-asphalt-based macromolecular self-adhesive layer and an interface bonding layer which are sequentially disposed, where the waterproof membrane has a light transmittance of ?45%. The present disclosure provides a visual waterproof membrane, that is, light may penetrate through the membrane to make gaskets visual, and when the membrane has a light transmittance of ?45%, it has good visibility for gaskets with warm colors such as orange and red.

Abstract: Pharmaceutical compositions comprising cholestenoic acids and deuterated derivatives thereof, methods of treatment or prevention of neurodegenerative conditions, as well as diagnostic methods and novel biomarkers form aspects of the invention.

Abstract: The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.

Abstract: An active driving intervention system and method based on acceleration rate optimization. After acquiring a distance from a vehicle ahead and a velocity of a driving vehicle, an evenly varying optimal acceleration variation when the driving vehicle is rapidly accelerated or rapidly decelerated in a safe condition may be calculated, which can be used to assist an accelerator or a brake in active intervention of a vehicle acceleration and appropriate adjustment of the opening of an accelerator or brake pedal, thereby realizing active intervention on driving operation. The method and system of the present disclosure can achieve the purpose of reducing energy consumption.

Abstract: A system without electrodes for identifying analytes based on optical measurement of ion flux through nanopores that is driven by a chemical gradient, and a method for identifying an analyte by using such system. A nanopore array without electrodes for identifying different analytes in parallel, a method for identifying different analytes by using such array, and a method of manufacturing such array.

Abstract: A method for preparing a bio-based composite using palm biomass powder as raw material, which belongs to the technical field of preparation methods for bio-based composites. During palm micropowder washing, 100 parts by weight of 600-1,200 mesh palm micropowder is placed in a reactor, and 400-500 parts by weight of acetone is added to the reactor in a 1:4 or 1:5 bath ratio; during surface treatment of palm micropowder, the reaction system after solvent displacement is heated to 80-100° C., and distillate is dehydrated with a 3A molecular sieve and then refluxed to a reactor; bio-based resin is compounded and extruded. At least one embodiment of the present invention solves the problem that use of palm as a biomass raw material leads to impurity migration and insufficient product performance due to high small oily molecule content.

Abstract: A method for preparing a bio-based composite using palm biomass powder as raw material, which belongs to the technical field of preparation methods for bio-based composites. During palm micropowder washing, 100 parts by weight of 600-1,200 mesh palm micropowder is placed in a reactor, and 400-500 parts by weight of acetone is added to the reactor in a 1:4 or 1:5 bath ratio; during surface treatment of palm micropowder, the reaction system after solvent displacement is heated to 80-100° C., and distillate is dehydrated with a 3A molecular sieve and then refluxed to a reactor; bio-based resin is compounded and extruded. At least one embodiment of the present invention solves the problem that use of palm as a biomass raw material leads to impurity migration and insufficient product performance due to high small oily molecule content.

Abstract: Pharmaceutical compositions comprising cholestenoic acids and deuterated derivatives thereof, methods of treatment or prevention of neurodegenerative conditions, as well as diagnostic methods and novel biomarkers form aspects of the invention.

Abstract: The present invention relates to methods for the diagnosis or prognosis of conditions caused by defects in cholesterol bio synthesis, such as Smith-Lemli-Opitz syndrome (SLOS), in particular to early diagnostic methods including in utero methods.

Abstract: The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.

Abstract: A reagent selected from cholestenoic acid or an inhibitor of an enzyme in the cholestenoic acid biosynthetic or metabolic pathway for use in the treatment of neurodegenerative conditions. in particular, the reagent is a cholestenoic acid of a particular form, such as 3?,7?-dihydroxycholest-5-en-26-oic (3?,7?-diHCA), not previously associated with neural tissue or CSF. Pharmaceutical compositions, methods of treatment or prevention of neurodegenerative conditions as well as diagnostic methods and novel biomarkers form further aspects of the invention.

Abstract: A reagent selected from cholestenoic acid or an inhibitor of an enzyme in the cholestenoic acid biosynthetic or metabolic pathway for use in the treatment of neurodegenerative conditions. In particular, the reagent is a cholestenoic acid of a particular form, such as 3?,7?-dihydroxycholest-5-en-26-oic (3?,7?-diHCA), not previously associated with neural tissue or CSF. Pharmaceutical compositions, methods of treatment or prevention of neurodegenerative conditions as well as diagnostic methods and novel biomarkers form further aspects of the invention.

Abstract: Compounds of general formula (I) wherein (I) RI-R4 are each independently selected from H and deuterium; and at least one of RI-R4 is deuterium. The compounds have been found to be particularly useful for treating neurodegenerative conditions and in particular but not exclusively conditions such as motor neurone disease.

Abstract: The present invention relates to methods for the diagnosis or prognosis of conditions caused by defects in cholesterol biosynthesis, such as Smith-Lemli-Opitz syndrome (SLOS), in particular to early diagnostic methods including in utero methods.

Abstract: The invention relates to a kit and methods for quantitative detection of steroids in a sample. The kit comprises quantitative charge tags and an oxidizing agent.

Abstract: Compounds of general formula (I) wherein (I) R1-R4 are each independently selected from H and deuterium; and at least one of R1-R4 is deuterium. The compounds have been found to be particularly useful for treating neurodegenerative conditions and in particular but not exclusively conditions such as motor neurone disease.

Abstract: A reagent selected from cholestenoic acid or an inhibitor of an enzyme in the cholestenoic acid biosynthetic or metabolic pathway for use in the treatment of neurodegenerative conditions. In particular, the reagent is a cholestenoic acid of a particular form, such as 3?,7?-dihydroxycholest-5-en-26-oic (3?,7?-diHCA), not previously associated with neural tissue or CSF. Pharmaceutical compositions, methods of treatment or prevention of neurodegenerative conditions as well as diagnostic methods and novel biomarkers form further aspects of the invention.

Abstract: The invention relates to a kit and methods for quantitative detection of steroids in a sample. The kit comprises quantitative charge tags and an oxidising agent.

Abstract: The present invention provides a data transmission method, a user equipment, and a network side device. The method includes generating a concurrency policy, which is used to indicate a user equipment to select at least one access network from at least two access networks to transmit at least one data stream. The concurrency policy is sent to the user equipment through a first data connection between a first access network in the at least two access networks and the user equipment.