Patents by Inventor Yuri Ivanovich Kozlov

Yuri Ivanovich Kozlov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine
    Patent number: 8071339
    Abstract: The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: December 6, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Elena Vitalievna Klyachko, Rustem Saidovich Shakulov, Yuri Ivanovich Kozlov
  • Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
    Patent number: 8003367
    Abstract: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: August 23, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Aleksey Nikolaevich Marchenko, Sergey Vladimirovich Benevolensky, Elena Vitalievna Klyachko, Yuri Ivanovich Kozlov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
    Patent number: 8003368
    Abstract: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: August 23, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Aleksey Nikolaevich Marchenko, Sergey Vladimirovich Benevolensky, Elena Vitalievna Klyachko, Yuri Ivanovich Kozlov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing L-histidine using bacteria which has an enhanced gene produced
    Patent number: 7785860
    Abstract: A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the AICAR transformylase-IMP cyclohydrolase encoded by the purH gene.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: August 31, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Elena Vitalievna Klyachko, Rustem Saidovich Shakulov, Yuri Ivanovich Kozlov
  • Mutant Phosphoribosylpyrophosphate Synthetase and Method for Producing L-Histidine
    Publication number: 20090275089
    Abstract: The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene.
    Type: Application
    Filed: February 15, 2008
    Publication date: November 5, 2009
    Inventors: Elena Vitalievna Klyachko, Rustem Saidovich Shakulov, Yuri Ivanovich Kozlov
  • METHOD FOR PRODUCING L-AMINO ACIDS BY FERMENTATION USING BACTERIA HAVING ENHANCED EXPRESSION OF XYLOSE UTILIZATION GENES
    Publication number: 20090117623
    Abstract: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
    Type: Application
    Filed: January 7, 2009
    Publication date: May 7, 2009
    Inventors: Aleksey Nikolaevich Marchenko, Sergey Vladimirovich Benevolensky, Elena Vitalievna Klyachko, Yuri Ivanovich Kozlov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Expression of the bolA Gene Attenuated
    Publication number: 20090081738
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the bolA gene.
    Type: Application
    Filed: July 31, 2007
    Publication date: March 26, 2009
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Tatyana Viktorovna Leonova, Yuri Ivanovich Kozlov, Vitaly Grigorievich Paraskevov
  • Method for producing L-histidine using bacteria of Enterobacteriaceae family
    Patent number: 7399618
    Abstract: A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talB gene.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: July 15, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Elena Vitalievna Klyachko, Rustam Saidovich Shakulov, Yuri Ivanovich Kozlov
  • Bacteria of the family having enhanced transaldolase activity
    Patent number: 7300786
    Abstract: A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talb gene.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: November 27, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Elena Vitalievna Klyachko, Rustam Saidovich Shakulov, Yuri Ivanovich Kozlov
  • L-threonine producing bacterium belonging to the genus and method for producing L-threonine
    Patent number: 7186531
    Abstract: There is disclosed a method for producing L-threonine using bacterium belonging to the genus Escherichia wherein the bacterium has been modified to enhance an activity of aspartate-?-semialdehyde dehydrogenase.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: March 6, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Alla Markovna Kaplan, Andrey Olegovich Lobanov, Yuri Ivanovich Kozlov
  • Method for procucing L-amino acid using bacterium, belonging to the genus Escherichia, lacking active mlc gene
    Publication number: 20040229320
    Abstract: The invention relates to a bacterium comprising an inactive mlc gene which produces an L-amino acid, such as L-threonine,
    Type: Application
    Filed: September 5, 2003
    Publication date: November 18, 2004
    Inventors: Natalia Viktorovna Stoynova, Elena Viktorovna Sycheva, Aleksandra Yurievna Skorokhodova, Yuri Ivanovich Kozlov
  • Process for producing L-amino acids by fermentation of a mixture of glucose and pentoses
    Publication number: 20040229321
    Abstract: A process for producing an L-amino acid, such as L-isoleucine, L-histidine, L-threonine and L-tryptophan, using bacterium belonging to the genus Escherichia is provided which comprises cultivating the L-amino acid-producing bacterium in a culture medium and collecting the L-amino acid from the culture medium, wherein the culture medium contains a mixture of glucose and pentose sugars, such as arabinose and xylose.
    Type: Application
    Filed: February 25, 2004
    Publication date: November 18, 2004
    Inventors: Ekaterina Alekseevna Savrasova, Elena Viktorovna Sycheva, Tatyana Anatolievna Michurina, Yuri Ivanovich Kozlov
  • Method for producing L-threonine using bacteria belonging to the genus Escherichia
    Publication number: 20040132165
    Abstract: There is disclosed a method for producing L-threonine using bacterium belonging to the genus Escherichia wherein the bacterium has L-theonine productivity and has been modified to enhance an activity of aspartate aminotransferase.
    Type: Application
    Filed: September 30, 2003
    Publication date: July 8, 2004
    Inventors: Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Alla Markovna Kaplan, Andrey Olegovich Lobanov, Yuri Ivanovich Kozlov
  • Method for producing shikimic acid
    Patent number: 6436664
    Abstract: A method for producing shikimic acid, comprising the steps of cultivating a bacterium belonging to the genus Bacillus which is deficient in shikimate kinase activity and has shikimic acid productivity, or a bacterium belonging to the genus Bacillus which is deficient in 5-enolpyruvylshikimate-3-phosphate synthase activity and has shikimic acid productivity, in an medium, producing and accumulating shikimic acid in the medium, and collecting shikimic acid from the medium.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: August 20, 2002
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yurgis Antanas Vladovich Iomantas, Elena Georgievna Abalakina, Boris Mironovich Polanuer, Tatyana Abramovna Yampolskaya, Tatyana Aleksandrovna Bachina, Yuri Ivanovich Kozlov