Patents by Inventor Yuri Petrovich Lysov

Yuri Petrovich Lysov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing
    Patent number: 6143499
    Abstract: A method for fractionating and sequencing DNA via affinity interaction is provided comprising contacting cleaved DNA to a first array of oligonucleotide molecules to facilitate hybridization between said cleaved DNA and the molecules; extracting the hybridized DNA from the molecules; contacting said extracted hybridized DNA with a second array of oligonucleotide molecules, wherein the oligonucleotide molecules in the second array have specified base sequences that are complementary to said extracted hybridized DNA; and attaching labeled DNA to the second array of oligonucleotide molecules, wherein the labeled re-hybridized DNA have sequences that are complementary to the oligomers.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: November 7, 2000
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Yuri Petrovich Lysov, Svetlana A. Dubley
  • Use of continuous/contiguous stacking hybridization as a diagnostic tool
    Patent number: 5908745
    Abstract: A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease associated alleles is immobilized on a predetermined position on a substrate, and then contacted with patient genetic material to form duplexes. The duplexes are then contacted with a second group of oligonucleotide molecules which are synthesized to extend the predetermined length of the oligonucleotide molecules of the first group, and where each of the oligonucleotide molecules of the second group are tagged and either incorporate universal bases or a mixture of guanine, cytosine, thymine, and adenine, or complementary nucleotide strands that are tagged with a different fluorochrome which radiates light at a predetermined wavelength.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: June 1, 1999
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Gennadiy Moseyevich Yershov, Eugene Vladislavovich Kirillov, Sergei Valeryevich Parinov, Victor Evgenievich Barski, Yuri Petrovich Lysov
  • Method for performing site-specific affinity fractionation for use in DNA sequencing
    Patent number: 5905024
    Abstract: A method for fractionating and sequencing DNA via affinity interaction is provided comprising contacting cleaved DNA to a first array of oligonucleotide molecules to facilitate hybridization between said cleaved DNA and the molecules; extracting the hybridized DNA from the molecules; contacting said extracted hybridized DNA with a second array of oligonucleotide molecules, wherein the oligonucleotide molecules in the second array have specified base sequences that are complementary to said extracted hybridized DNA; and attaching labeled DNA to the second array of oligonucleotide molecules, wherein the labeled re-hybridized DNA have sequences that are complementary to the oligomers.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: May 18, 1999
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Yuri Petrovich Lysov, Svetlana A. Dubley
  • Microchip method for the enrichment of specific DNA sequences
    Patent number: 5851772
    Abstract: A method for enriching specific genetic material sequences is provided, whereby oligonucleotide molecules complementary to the desired genetic material is first used to isolate the genetic material from a first source of genomic material. Then the genetic material is used as a label to isolate similar genetic sequences from other sources.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: December 22, 1998
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Yuri Petrovich Lysov, Valentine Vladimirovich Shick, Svetlana Alekseevna Dubiley