Abstract: Provided is a composition for the treatment of vascular disease, for the prevention of vascular disease, for the treatment of hypertension or for the prevention of hypertension, comprising caryophyllene.

Abstract: Provided are a novel agent or composition and others. The agent or composition comprises caryophyllene and is used for at least one selected from the following (purposes) (1) to (3) : (1) promoting relaxation, prolonging a resting-state time, and/or prolonging a motionless time, (2) promoting sleep, and (3) preventing blood pressure elevation. The present invention also relates to a method for inhaling ?-caryophyllene simultaneously with smoking a tobacco product, characterized in that the tobacco product contains a ?-caryophyllene-containing seamless capsule in a tobacco filter, wherein the seamless capsule contains an essential oil containing ?-caryophyllene as an active ingredient. The applicants found that pulmonary inhalation of ?-caryophyllene by the above method allows ?-caryophyllene to be efficiently distributed throughout the body, leading to achievements of relaxing and sleep-inducing effects, etc.

Abstract: The present application aims to provide a method for producing a coffee beverage in which excellent flavor, aroma, taste are contained even after the sterilization process. The method includes the steps of soaking or wetting the coffee beans with hot water, wherein the coffee beans are roasted and ground, steam-distilling the coffee beans to collect a distilled liquid, extracting a distilled residue with hot water to collect the extracted liquid, mixing the distilled liquid with the extracted liquid to obtain the coffee extract and adding agent for adjusting pH and/or ascorbic acid into the coffee extract.