Abstract: A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed.

Abstract: A solid preparation 1 comprises a drug-containing unit 2 containing a cationic drug, and a gel-forming layer 4, containing an anionic polymer, for covering the drug-containing unit 2 and forming a gel with absorbing water, and optionally an intermediate layer 3 interposed between the drug-containing unit 2 and the gel-forming layer 4. The solid preparation 1 improves the elution property of the drug by incorporating an acidic component (such as tartaric acid or citric acid) into the intermediate layer 2 and/or the intermediate layer 3. The gel-forming layer 4 may comprise a carboxyvinyl polymer and a polyvalent metal compound. The gel-forming layer 4 may be covered with a surface layer (anti-adhesive layer) 5.

Abstract: A solid preparation 1 comprises a drug-containing unit 2 containing a cationic drug, and a gel-forming layer 4, containing an anionic polymer, for covering the drug-containing unit 2 and forming a gel with absorbing water, and optionally an intermediate layer 3 interposed between the drug-containing unit 2 and the gel-forming layer 4. The solid preparation 1 improves the elution property of the drug by incorporating an electrolyte (e.g., calcium chloride) into the intermediate layer 2 and/or the intermediate layer 3. The gel-forming layer 4 may comprise a carboxyvinyl polymer and a polyvalent metal compound. The gel-forming layer 4 may be covered with a surface layer (anti-adhesive layer) 5.

Abstract: An adhesion of a preparation 1 to an inner wall of an oral cavity is prevented by applying an anti-adhesive composition containing a water-soluble cellulose ether (e.g., an HPMC) and an anionic polymer (e.g., a carboxyvinyl polymer) to a gel-forming layer 4 covering a drug-containing unit 2 to form an anti-adhesive layer 5. The gel-forming layer 4 may be formed with a gel-forming agent (a carboxyvinyl polymer), a crosslinking agent, and a base material (e.g., a poly(vinyl alcohol)). An adhesive layer 3 may be interposed between the drug-containing unit 2 and the gel-forming layer 4.

Abstract: An orally-administered agent is provided. The orally-administered agent comprises an intestinal medicine-containing layer containing a medicine to be released in intestines and having surfaces; intestinal collapse-controlling layers provided directly or through an arbitrary layer on the surfaces of the intestinal medicine-containing layer, respectively, at least a part of the intestinal collapse-controlling layers being collapsed in the intestines, and each of the intestinal collapse-controlling layers having a surface opposite to the intestinal medicine-containing layer; and gel-forming layers provided directly or through an arbitrary layer on the sides of the surfaces of the intestinal collapse-controlling layers, respectively, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The intestinal collapse-controlling layers are constituted of a material containing an enteric material to be dissolved by being in contact with a body fluid in the intestines.

Abstract: An orally-administered agent according to the present invention comprises: a medicine-containing layer containing a medicine and having surfaces; collapse-controlling layers respectively provided on the surfaces of the medicine-containing layer; and gel-forming layers respectively provided on the collapse-controlling layers, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The collapse-controlling layers are constituted of a material containing a stomach-soluble material to be dissolved by being in contact with gastric juice. The orally-administered agent according to the present invention can be swallowed with ease and release the medicine in intended parts, in particular, the stomach of a living body.

Abstract: An edible film to be ingested from an oral cavity of a living body to a body thereof is provided. The edible film is comprised of a laminated body consisting of a plurality of layers. The laminated body has surfaces and the plurality of layers include two surface layers forming of the surfaces of the laminated body. At least one of the two surface layers is disposed as an antiadhesive layer for preventing the edible film from adhering to an inside wall of the oral cavity by dissolving with water. This edible film is a film that it is difficult to adhere to the inside wall of the oral cavity, and even if it adheres to the inside wall, it is possible to easily peel off the edible film therefrom.

Abstract: An orally-administered agent comprised of a laminated body having surface layers is provided. The laminated body comprises a medicine-containing layer containing a medicine and having surfaces; and at least one gel-forming layer provided on one of the surfaces of the medicine-containing layer as one of the surface layers of the laminated body. The at least one gel-forming layer includes a gel-forming agent to be swelled and gelatinized when absorbing a water-based liquid. A water absorption speed per 1 g of the gel-forming layer with respect to water of 37° C. is 0.5 g/(g·s) or higher. A gel fraction of the gel-forming layer is 20 mass % or more when the gel-forming layer is dipped into an aqueous solution of 0.9 mass % of sodium chloride having a temperature of 37° C.

Abstract: Film-like orally administered medications are provided which are less likely to be attached to the oral mucous membrane upon intake and can be easily detached therefrom even if attached thereto. A film-like orally administered medication (1) includes at least a medical-agent-containing layer (11). Convex portions are formed on at least one surface of the orally administered medication (1). The convex portions have at least one type of shape selected from among tapers, columns, hemispheres, and frustums. The medical-agent-containing layer includes a medical agent and a base substance.

Abstract: A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed.