Patents by Inventor Yusuf A. Hannun
Yusuf A. Hannun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230353399Abstract: In some aspects, a computing device may access audio information comprising an audio stream from a client device. The computing device may provide an audio segment from the audio stream to a language identification process of the computing device comprising a machine learning model that is trained to identify a language of a plurality of languages within recorded speech. The computing device may identify an identified-language of the plurality of languages for the speech based at least in part on the audio segment. The computing device may provide the identified-language to the client device. Numerous other aspects are described.Type: ApplicationFiled: April 29, 2022Publication date: November 2, 2023Applicant: Zoom Video Communications, Inc.Inventors: Awni Yusuf Hannun, Sebastian Stüker
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Publication number: 20230352011Abstract: In some aspects, a computing device may access audio information comprising an audio stream from a client device, and a source-language. The computing device may provide an audio segment from the audio stream to a language identification process of the computing device comprising a machine learning model that is trained to identify a language of a plurality of languages within recorded speech. The computing device may identify an identified-language of the plurality of languages for the speech based at least in part on the audio segment. The computing device may update the source-language to the identified language. Numerous other aspects are described.Type: ApplicationFiled: April 29, 2022Publication date: November 2, 2023Applicant: Zoom Video Communications, Inc.Inventors: Awni Yusuf HANNUN, Sebastian Stüker
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Patent number: 8697379Abstract: The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.Type: GrantFiled: November 6, 2009Date of Patent: April 15, 2014Assignee: MUSC Foundation for Research DevelopmentInventors: Alicja Bielawska, Aiping Bai, Zdzislaw M. Szulc, Yusuf A. Hannun, James S. Norris, Liu Xiang
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Patent number: 8592419Abstract: The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.Type: GrantFiled: October 31, 2005Date of Patent: November 26, 2013Assignee: MUSC Foundation for Research DevelopmentInventors: Alicja Bielawska, Yusuf A. Hannun, James Norris, Zdzislaw M. Szulc, Jian-yun Dong, Jacek Bielawski, David A. Schwartz, David H. Holman, Ahmed M. El-Zawahry, John McKillop
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Publication number: 20120108667Abstract: Disclosed herein are compounds, compositions, methods of treatment and synthetic methods for making compounds related to Ceramides and the use of Ceramides.Type: ApplicationFiled: October 31, 2011Publication date: May 3, 2012Inventors: Zdzislaw M. Szulc, Alicja Bielawska, Yusuf A. Hannun
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Publication number: 20120035268Abstract: The presently disclosed subject matter provides compounds of the formula: (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting sphingosine kinase, and their use in the treatment and/or prevention of diseases and/or conditions associated with undesirable ceramidase or sphingosine kinase activity, including, but not limit cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, immunological disorders, asthma, atopic dermatitis, wound healing, and other proliferative diseases.Type: ApplicationFiled: December 28, 2009Publication date: February 9, 2012Inventors: Zdzislaw M. Szulc, Alicja Bielawska, Lina M. Obeld, Yusuf A. Hannun, James Norris, Liu Xiang
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Patent number: 8093393Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.Type: GrantFiled: October 31, 2005Date of Patent: January 10, 2012Assignee: MUSC Foundation for Research DevelopmentInventors: Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen
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Publication number: 20110071099Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.Type: ApplicationFiled: October 31, 2005Publication date: March 24, 2011Inventors: Alicja Bielawska, Zdzislaw M. Szuic, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen
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Publication number: 20080045470Abstract: The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.Type: ApplicationFiled: October 31, 2005Publication date: February 21, 2008Inventors: Alicja Bielawska, Yusuf Hannun, James Norris, Zdzislaw Szulc, Jian-yun Dong, Jacek Bielawski, David Schwartz, David Holman, Ahmed El-Zawahry, John McKillop
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Publication number: 20060030537Abstract: The invention relates to a method of inhibiting the production of ceramide-1-phosphate in a cell by delivering to the cell a ceramide kinase antagonist. The invention also relates to a method of treating a condition related to activation of phospholipase A2 in a subject by administering to the subject a pharmaceutical composition comprising a ceramide kinase antagonist. The invention further relates to the use of ceramide kinase in drug screening assays. The invention also encompasses compounds that inhibit the production of ceramide-1-phosphate by ceramide kinase.Type: ApplicationFiled: July 11, 2005Publication date: February 9, 2006Inventors: Charles Chalfant, Yusuf Hannun, Benjamin Pettus, Alicja Bielawska
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Publication number: 20050043534Abstract: The present invention relates to compounds which can be used as inhibitors of mitochondrial ceramidase, in particular human mitochondrial ceramidase. The invention also relates to methods of designing and making the compounds, as well as methods screening for compounds that inhibit mitochondrial ceramidase. The invention also relates to the use of the compounds as a regulator of the level of ceramide by inhibiting ceramidase activity. The invention also relates to methods for the prevention and treatment of diseases associated with cell overproliferation and sphingolipid signal transduction including cancer, cardiovascular diseases, and inflammation.Type: ApplicationFiled: July 11, 2002Publication date: February 24, 2005Inventors: Alicja Bielawska, Yusuf Hannun, Zdzislaw Szulc, Julnar Usta, Samer El Bawab
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Patent number: 5851782Abstract: The present invention relates, in general, to the bioeffector molecule ceramide and, in particular, to methods of effecting intracellular accumulation of ceramide. The invention further relates to methods of selecting compounds that inhibit alkaline ceramidase and that can be used to treat diseases/disorders associated with cell hyperplasia or dedifferentiation.Type: GrantFiled: November 8, 1996Date of Patent: December 22, 1998Assignee: Duke UniversityInventors: Yusuf A. Hannun, Alicja Bielawska, Charles McKay
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Patent number: 5830916Abstract: The present invention relates, in general, to the bioeffector molecule ceramide and, in particular, to methods of effecting intracellular accumulation of ceramide. The invention further relates to methods of selecting compounds that inhibit alkaline ceramidase and that can be used to treat diseases/disorders associated with cell hyperplasia or dedifferentiation.Type: GrantFiled: May 23, 1996Date of Patent: November 3, 1998Assignee: Duke UniversityInventors: Yusuf A. Hannun, Alicja Bielawska, Charles McKay
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Patent number: 5369030Abstract: The present invention provides methods and pharmaceutical preparations of N-acyl-phenylaminoalcohol analogs for inducing differentiation of cells. Compositions having the formula ##STR1## wherein R.sub.1 is H, NO.sub.2, OH, chlorine, bromine or fluorine;R.sub.2 is H, OH or methoxy;R.sub.3 is H or OH; andm is from about 10 to about 14are administered to cells of a mammal that are capable of undergoing differentiation in amounts effective to induce differentiation of the cells. The invention also provides methods and pharmaceutical preparations for altering the phenotype of cells and for treating diseases characterized by hyperproliferation of cells.Type: GrantFiled: September 11, 1992Date of Patent: November 29, 1994Assignee: Duke UniversityInventors: Yusuf A. Hannun, Alicja Bielawska
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Patent number: 4937232Abstract: Compositions for inhibiting protein kinase C, comprising an inhibitory amount of a compound having the formula: ##STR1## wherein Q is a hydrophobic group; wherein X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, which may be substituted by one or more halogens or C.sub.1 -C.sub.3 alkyl groups,wherein Y is ##STR2## wherein W is a halogen; wherein R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, lower alkyl groups having from 1 to 7 carbon atoms, aralkyl, and aryl groups, andwherein Z is a phosphate or an organic group, and a pharmaceutically acceptable carrier material; and a method for inhibiting protein kinase C using such compositions.Type: GrantFiled: May 17, 1988Date of Patent: June 26, 1990Assignee: Duke UniversityInventors: Robert M. Bell, Carson Loomis, Yusuf Hannun
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Patent number: 4816450Abstract: Compositions for inhibiting protein kinase C, comprising an inhibitory amount of a compound having the formula: ##STR1## wherein Q is a hydrophobic group; wherein X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, which may be substituted by one or more halogens or C.sub.1 -C.sub.3 alkyl groups,wherein Y is ##STR2## wherein W is a halogen; wherein R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, lower alkyl groups having from 1 to 7 carbon atoms, aralkyl, and aryl groups, andwherein Z is a phosphate or an organic group, and a pharmaceutically acceptable carrier material; and a method for inhibiting protein kinase C using such compositions.Type: GrantFiled: September 15, 1986Date of Patent: March 28, 1989Assignee: Duke UniversityInventors: Robert M. Bell, Carson Loomis, Yusuf Hannun