Abstract: In some aspects, a computing device may access audio information comprising an audio stream from a client device. The computing device may provide an audio segment from the audio stream to a language identification process of the computing device comprising a machine learning model that is trained to identify a language of a plurality of languages within recorded speech. The computing device may identify an identified-language of the plurality of languages for the speech based at least in part on the audio segment. The computing device may provide the identified-language to the client device. Numerous other aspects are described.

Abstract: In some aspects, a computing device may access audio information comprising an audio stream from a client device. The computing device may provide an audio segment from the audio stream to a language identification process of the computing device comprising a machine learning model that is trained to identify a language of a plurality of languages within recorded speech. The computing device may identify an identified-language of the plurality of languages for the speech based at least in part on the audio segment. The computing device may provide the identified-language to the client device. Numerous other aspects are described.

Abstract: In some aspects, a computing device may access audio information comprising an audio stream from a client device. The computing device may provide an audio segment from the audio stream to a language identification process of the computing device comprising a machine learning model that is trained to identify a language of a plurality of languages within recorded speech. The computing device may identify an identified-language of the plurality of languages for the speech based at least in part on the audio segment. The computing device may provide the identified-language to the client device. Numerous other aspects are described.

Abstract: In some aspects, a computing device may access audio information comprising an audio stream from a client device, and a source-language. The computing device may provide an audio segment from the audio stream to a language identification process of the computing device comprising a machine learning model that is trained to identify a language of a plurality of languages within recorded speech. The computing device may identify an identified-language of the plurality of languages for the speech based at least in part on the audio segment. The computing device may update the source-language to the identified language. Numerous other aspects are described.

Abstract: The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.

Abstract: The invention relates to a method of inhibiting the production of ceramide-1-phosphate in a cell by delivering to the cell a ceramide kinase antagonist. The invention also relates to a method of treating a condition related to activation of phospholipase A2 in a subject by administering to the subject a pharmaceutical composition comprising a ceramide kinase antagonist. The invention further relates to the use of ceramide kinase in drug screening assays. The invention also encompasses compounds that inhibit the production of ceramide-1-phosphate by ceramide kinase.

Abstract: The present invention relates to compounds which can be used as inhibitors of mitochondrial ceramidase, in particular human mitochondrial ceramidase. The invention also relates to methods of designing and making the compounds, as well as methods screening for compounds that inhibit mitochondrial ceramidase. The invention also relates to the use of the compounds as a regulator of the level of ceramide by inhibiting ceramidase activity. The invention also relates to methods for the prevention and treatment of diseases associated with cell overproliferation and sphingolipid signal transduction including cancer, cardiovascular diseases, and inflammation.

Abstract: Compositions for inhibiting protein kinase C, comprising an inhibitory amount of a compound having the formula: ##STR1## wherein Q is a hydrophobic group; wherein X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, which may be substituted by one or more halogens or C.sub.1 -C.sub.3 alkyl groups,wherein Y is ##STR2## wherein W is a halogen; wherein R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, lower alkyl groups having from 1 to 7 carbon atoms, aralkyl, and aryl groups, andwherein Z is a phosphate or an organic group, and a pharmaceutically acceptable carrier material; and a method for inhibiting protein kinase C using such compositions.

Abstract: Compositions for inhibiting protein kinase C, comprising an inhibitory amount of a compound having the formula: ##STR1## wherein Q is a hydrophobic group; wherein X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, which may be substituted by one or more halogens or C.sub.1 -C.sub.3 alkyl groups,wherein Y is ##STR2## wherein W is a halogen; wherein R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, lower alkyl groups having from 1 to 7 carbon atoms, aralkyl, and aryl groups, andwherein Z is a phosphate or an organic group, and a pharmaceutically acceptable carrier material; and a method for inhibiting protein kinase C using such compositions.