Abstract: A diagnostic system is used for measuring and analyzing startle response of a subject for diagnosis of traumatic brain injuries (TBI) such as concussions. The diagnostic system includes a stimuli delivery circuitry, whereby startle stimuli are delivered to the subject. The diagnostic system comprises at least one sensor circuitry, whereby the startle response of the subject are detected and recorded. The sensor circuitry comprises at least one muscle startle response measuring means, and said diagnostic system comprises a diagnosis circuitry whereby the features of the startle response are extracted and analyzed.

Abstract: A system and method for non-invasively applying electrical stimulation to target the olfactory bulb and olfactory mucosa. Current is delivered through an optimal montage of electrodes positioned on the lower forehead, nose bridge, and neck posterior for suppressing the progression of disorders or alleviating symptoms caused by olfactory dysfunction such as Alzheimer’s Disease, Parkinson’s Disease, Loss of Consciousness, etc. Electrode placements are proposed depending on application- for instance using only hair free zones for stimulation. This invention was made with government support under Grant R44NS092144 awarded by the National Institutes of Health. The government has certain rights in the invention.

Abstract: A stimulation device includes a body containing at least one stimulation means adapted to be transcutaneously attached to the neck of a subject. The stimulation means is adapted to generate a stimulating signal during a stimulating state. The stimulation means is positioned to be in stimulating contact with the sternocleidomastoid muscle and the trunks of the lesser occipital nerve, greater auricular nerve, transverse cervical nerve or supraclavicular nerve with their autonomic fibers synchronously. The stimulation can be provided in the form an electrical, optical, vibrational, thermal, mechanical and/or magnetic stimulation. The stimulation device can be used bilaterally on the right and left sides of the subject's neck, working as a system in a synchronous or alternating manner.

Abstract: An electro-stimulation apparatus provides stimulation of the supplementary motor area, premotor area, cerebellum and/or subthalamic nucleus of a human. The electro-stimulation apparatus includes at least one micro needle electrode having a stimulation end and a base. Said at least one micro needle electrode is provided with a stimulation end configured to stimulate intrinsic auricular muscles of the human and said stimulation end of said micro needle electrode is adapted to generate an electrical stimulation signal during a stimulating state.

Abstract: An electro-simulation system includes an electro-stimulation device where the supplementary motor area, premotor area and/or subthalamic nucleus are stimulated extra-cranially. The electro-stimulation device includes at least one electrode, said at least one electrode being provided with a stimulation end configured to be directly attached to intrinsic auricular muscles of a human so as to establish a direct contact relation therewith, said stimulation end being operatively coupled with a sensor.

Abstract: A diagnostic system for measuring and analyzing startle response of a subject comprises a stimuli delivery circuitry, whereby startle stimuli and prepulse stimuli are delivered to the subject. Said diagnostic system comprises at least one sensor circuitry, whereby the startle response(s) of the subject are detected and recorded. Said sensor circuitry comprises at least one electrode and one eye response measuring system, such as a camera. Said diagnostic system comprises a diagnosis circuitry whereby the features of the startle response(s) and prepulse inhibition of the subject are extracted and analyzed. Said startle response(s) of said subject detected by said sensor circuitry comprise eye response, such as pupillary response and/or eyeblink response, post-auricular muscle response and intrinsic auricular muscle response.

Abstract: An electro-stimulation device where the innervation of the external ear canal is transcutaneously stimulated for treatment of neurological diseases. More particularly, an electrostimulation device having a cylindrical ear insert the surface of which contains at least one electrode being provided with a stimulation end adapted to be transcutaneously attached to the innervation of the external ear canal of a human. The electro-stimulation device is configured to stimulate anterior, superior, posterior or inferior positions of the external ear canal to stimulate simultaneously, sequentially or separately the trigeminal nerve, facial nerve, vagus nerve or glossopharyngeal nerve of the external ear canal.

Abstract: A blood pressure decreasing system that decreases blood pressure of a patient by noninvasively blocking the sympathetic innervation of the kidney, blocking all three pathways of the sympathetic nerves to adrenal gland medulla and expanding the renal artery of the patient. The blood pressure decreasing system has at least one sensor for measuring the blood pressure of the patient and generates systolic blood pressure value and/or diastolic blood pressure value; at least two electrodes that are placed to skin dermatomal of the patient; at least one stimulator that sends electrical signals to electrodes in order to block the sympathetic nerve innervation to arterial smooth muscle and kidney, all three pathways of the sympathetic nerves to adrenal medulla and expand renal artery of the patient; and at least one control unit, which receives the blood pressure values from said sensor, compares received values with predetermined threshold values and controls the stimulator.

Abstract: A diagnostic system is used for measuring and analyzing startle response of a subject for diagnosis of traumatic brain injuries (TBI) such as concussions. The diagnostic system includes a stimuli delivery circuitry, whereby startle stimuli are delivered to the subject. The diagnostic system comprises at least one sensor circuitry, whereby the startle response of the subject are detected and recorded. The sensor circuitry comprises at least one muscle startle response measuring means, and said diagnostic system comprises a diagnosis circuitry whereby the features of the startle response are extracted and analyzed.

Abstract: A diagnostic system for measuring and analyzing startle response of a subject comprises a stimuli delivery module, whereby startle stimuli and prepulse stimuli are delivered to subject; said diagnostic system comprises at least one sensor module, whereby the startle response of subject are detected and recorded; said sensor module comprises at least one electrode and one eyeblink response measuring means; and said diagnostic system comprises a diagnosis module whereby the features of the startle response and prepulse inhibition of subject are extracted and analyzed.

Abstract: A blood glucose level decreasing system that decreases blood glucose level of a patient by blocking the sympathetic innervation to liver and pancreas and smooth muscles of the arteries reaching to liver and pancreas with noninvasive electrostimulation of the skin which have the sympathetic nerves originating from the same spinal cord segments. The blood glucose level decreasing system has at least one sensor for measuring the blood glucose level of the patient; at least two electrodes that are placed to skin dermatomal of the patient; at least one stimulator that sends electrical signals to the electrodes to block the sympathetic nerve innervation to smooth muscles of hepatic artery proper and liver, and expand liver artery of the patient; and at least one control unit, which receives the blood glucose level from the sensor, compares received level with a predetermined threshold value and controls the stimulator according to the result.

Abstract: A diagnostic system for measuring and analyzing startle response of a subject comprises a stimuli delivery circuitry, whereby startle stimuli and prepulse stimuli are delivered to the subject. Said diagnostic system comprises at least one sensor circuitry, whereby the startle response(s) of the subject are detected and recorded. Said sensor circuitry comprises at least one electrode and one eye response measuring system, such as a camera. Said diagnostic system comprises a diagnosis circuitry whereby the features of the startle response(s) and prepulse inhibition of the subject are extracted and analyzed. Said startle response(s) of said subject detected by said sensor circuitry comprise eye response, such as pupillary response and/or eyeblink response, post-auricular muscle response and intrinsic auricular muscle response.

Abstract: An electro-stimulation device where the innervation of the external ear canal is transcutaneously stimulated for treatment of neurological diseases. More particularly, an electrostimulation device having a cylindrical ear insert the surface of which contains at least one electrode being provided with a stimulation end adapted to be transcutaneously attached to the innervation of the external ear canal of a human. The electro-stimulation device is configured to stimulate anterior, superior, posterior or inferior positions of the external ear canal to stimulate simultaneously, sequentially or separately the trigeminal nerve, facial nerve, vagus nerve or glossopharyngeal nerve of the external ear canal.

Abstract: A blood pressure decreasing system that decreases blood pressure of a patient by noninvasively blocking the sympathetic innervation of the kidney, blocking all three pathways of the sympathetic nerves to adrenal gland medulla and expanding the renal artery of the patient. The blood pressure decreasing system has at least one sensor for measuring the blood pressure of the patient and generates systolic blood pressure value and/or diastolic blood pressure value; at least two electrodes that are placed to skin dermatomal of the patient; at least one stimulator that sends electrical signals to electrodes in order to block the sympathetic nerve innervation to arterial smooth muscle and kidney, all three pathways of the sympathetic nerves to adrenal medulla and expand renal artery of the patient; and at least one control unit, which receives the blood pressure values from said sensor, compares received values with predetermined threshold values and controls the stimulator.

Abstract: A blood glucose level decreasing system that decreases blood glucose level of a patient by blocking the sympathetic innervation to liver and pancreas and smooth muscles of the arteries reaching to liver and pancreas with noninvasive electrostimulation of the skin which have the sympathetic nerves originating from the same spinal cord segments. The blood glucose level decreasing system has at least one sensor for measuring the blood glucose level of the patient; at least two electrodes that are placed to skin dermatomal of the patient; at least one stimulator that sends electrical signals to the electrodes to block the sympathetic nerve innervation to smooth muscles of hepatic artery proper and liver, and expand liver artery of the patient; and at least one control unit, which receives the blood glucose level from the sensor, compares received level with a predetermined threshold value and controls the stimulator according to the result.

Abstract: An electro-simulation system includes an electro-stimulation device where the supplementary motor area, premotor area and/or subthalamic nucleus are stimulated extra-cranially. The electro-stimulation device includes at least one electrode, said at least one electrode being provided with a stimulation end configured to be directly attached to intrinsic auricular muscles of a human so as to establish a direct contact relation therewith, said stimulation end being operatively coupled with a sensor.

Abstract: A diagnostic system for measuring and analyzing startle response of a subject comprises a stimuli delivery module, whereby startle stimuli and prepulse stimuli are delivered to subject; said diagnostic system comprises at least one sensor module, whereby the startle response of subject are detected and recorded; said sensor module comprises at least one electrode and one eyeblink response measuring means; and said diagnostic system comprises a diagnosis module whereby the features of the startle response and prepulse inhibition of subject are extracted and analyzed.

Abstract: An electro-stimulation device where the supplementary motor area, premotor area and/or subthalamic nucleus is stimulated extracranially via intrinsic auricular muscles and the stimulation intensity of the supplementary motor area, premotor area and/or subthalamic nucleus is changed with the intensity of the tremors. The electro-stimulation device comprises; at least two primary electrodes which enables sending and receiving electric signals, at least one control unit which produces stimulating signals for reducing involuntary resting activities such as tremors and enables these signals to be sent to/received from primary electrodes.

Abstract: A system for decreasing the blood flow of a targeted organ in case of bleeding or a medical requirement includes an integrated electrostimulator and a subsystem.

Abstract: An electro-stimulation device where the supplementary motor area, premotor area and/or subthalamic nucleus is stimulated extracranially via intrinsic auricular muscles and the stimulation intensity of the supplementary motor area, premotor area and/or subthalamic nucleus is changed with the intensity of the tremors. The electro-stimulation device comprises; at least two primary electrodes which enables sending and receiving electric signals, at least one control unit which produces stimulating signals for reducing involuntary resting activities such as tremors and enables these signals to be sent to/received from primary electrodes.