Abstract: Novel compounds having a D3 receptor antagonistic activity are provided. The compound represented by Formula (I): wherein Ring A is a non-aromatic heterocycle or the like substituted with substituted or unsubstituted aromatic heterocyclyl or the like; R2a to R2d are each independently a hydrogen atom or the like; n is an integer of 0 to 3; Ring B is a non-aromatic carbocycle or the like; R3 is each independently halogen or the like; r is an integer of 0 to 4; -L- is —N(R10)—C(?O), or the like; R10 is a hydrogen atom or the like; R4 is substituted or unsubstituted aromatic heterocyclyl or the like, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention enables machining to be easily performed and reduces stress concentration on a machined hole that is formed in a cylindrical member. Recesses (2) recessed in the depth direction of a machined hole (1) are formed on circumferential side-portions of the machined hole 1 formed in a cylindrical member (10). In each of the recesses (2), a part of the opening edge is formed to be a circular arc portion (2a) that has a circular arc shape, the bottom is formed to be gradually shallowed by an inclined surface (2c) toward an opened portion (2b) in which the circular arc shape is opened, from a part along the circular arc portion (2a), and the circular arc portion (2a) is disposed toward the machined hole (1).

Abstract: Novel compounds having a D3 receptor antagonistic activity are provided. The compound represented by Formula (I): wherein Ring A is a non-aromatic heterocycle or the like substituted with substituted or unsubstituted aromatic heterocyclyl or the like; R2a to R2d are each independently a hydrogen atom or the like; n is an integer of 0 to 3; Ring B is a non-aromatic carbocycle or the like; R3 is each independently halogen or the like: r is an integer of 0 to 4; -L- is —N(R10)—C(?O), or the like; R10 is a hydrogen atom or the like; R4 is substituted or unsubstituted aromatic heterocyclyl or the like, or a pharmaceutically acceptable salt thereof.

Abstract: A case is provided for a gas turbine engine. The case includes a wall defining a through-hole. The case also includes first and second pockets adjacent to, and on opposite sides, of the through hole. A method of reducing stress in a case of a gas turbine engine is also provided that includes reducing stress about a through-hole by providing a concavity on each side of the through-hole.

Abstract: The present invention enables machining to be easily performed and reduces stress concentration on a machined hole that is formed in a cylindrical member. Recesses (2) recessed in the depth direction of a machined hole (1) are formed on circumferential side-portions of the machined hole 1 formed in a cylindrical member (10). In each of the recesses (2), a part of the opening edge is formed to be a circular arc portion (2a) that has a circular arc shape, the bottom is formed to be gradually shallowed by an inclined surface (2c) toward an opened portion (2b) in which the circular arc shape is opened, from a part along the circular arc portion (2a), and the circular arc portion (2a) is disposed toward the machined hole (1).

Abstract: The present invention is related to a compound represented by formula (I) wherein —X— is —NH— or —S—; —Z— is —O— or —S—; R3, R5 and R6 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R7 is a cyano, substituted or unsubstituted amino, or the like; R7? is each independently a halogen; b is 0 or 1; or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

Abstract: The present invention is related to a compound represented by formula (I) wherein —X— is —NH— or —S—; —Z— is —O— or —S—; R3, R5 and R6 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R7 is a cyano, substituted or unsubstituted amino, or the like; R7? is each independently a halogen; b is 0 or 1; or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

Abstract: A case is provided for a gas turbine engine. The case includes a wall defining a through-hole. The case also includes first and second pockets adjacent to, and on opposite sides, of the through hole. A method of reducing stress in a case of a gas turbine engine is also provided that includes reducing stress about a through-hole by providing a concavity on each side of the through-hole.