Abstract: A peroxide-resistant endoscope comprises an interface portion; a control portion coupled to the interface portion; and an insertion portion coupled to the control portion. The insertion portion comprises a bending portion; an insertion tube extending from a distal end of the control portion to a proximal end of the bending portion; a bending portion coupled to a distal end of the insertion tube; and a distal tip at a distal end of the bending portion. The peroxide-resistant endoscope also comprises a light carrying bundle (LCB) that extends from the interface portion to the distal tip. An outer casing of the bending portion consists essentially of fluorocarbon rubber, the LCB is lubricated by a first lubricant that comprises at least one solid lubricant and does not contain more than ten percent by weight of molybdenum disulfide, and an outer casing of the insertion tube is bonded to the outer casing of the bending portion by an epoxy adhesive.

Abstract: Provided are a substance capable of binding to EGFR specifically with a high affinity and a pharmaceutical agent containing the substance. A peptide which contains at least an amino acid sequence is represented by the formula (1), (2) or (3), as described in the specification, and is composed of 12 to 50 amino acids: (SEQ?ID?NO:?55) X1-His-X2-X3-Asp-X4-X5-X6-X7-X8-Trp-His(1) (SEQ?ID?NO:?56) Phe-His-Asp-Trp-X11-Pro-X12-X13-X14-X15-X16-X17(2) (SEQ?ID?NO:?57) Leu-His-X21-Ser-X22-Trp-Met-X23-X24-X25-X26-X27(3).

Abstract: Provided are a substance capable of binding to EGFR specifically with a high affinity and a pharmaceutical agent containing the substance.

Abstract: The present invention provides an agent and a method for enhancing a contrast of an image of fluorescent staining of a lumen of the digestive tract with an intravenously administered fluorescent dye, wherein the agent for enhancing a contrast is an agent for a lumen of the digestive tract containing an aqueous solution having a buffer capacity and having a pH of 6 to 10.

Abstract: A liquid applicator for an endoscope configured to apply liquid to in vivo tissue includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a brush member provided at a distal end of the flexible tube, and a fluid channel formed in the flexible tube to supply the liquid to the brush member.

Abstract: An endoscope for magnified image observation configured to observe a magnified image of in vivo tissue comprises an insertion part configured to be inserted into a body, a magnified image observation port configured to take in the magnified image of the in vivo tissue in one of a state where the magnified image observation port is in contact with the in vivo tissue and a state where the magnified image observation port is in proximity to the in vivo tissue, the observation port being provided at a distal end of the insertion part, and a marking unit configured to mark the in vivo tissue in one of the state where the magnified image observation port is in contact with the in vivo tissue and the state where the magnified image observation port is in proximity to the in vivo tissue.

Abstract: Highly dispersible inorganic compound nanoparticles modified by functional molecules include the functional molecules; a high molecular nitrogen compound having at least two amino groups selected from primary amino groups, secondary amino groups and tertiary amino groups; and inorganic compound nanoparticles bonded to at least one amino group of the at least two amino groups. The high molecular nitrogen compound is modified by the functional molecules, and the inorganic compound nanoparticles are covered with the high molecular nitrogen compound modified by the functional molecules.

Abstract: Highly dispersible inorganic compound nanoparticles modified by functional molecules include the functional molecules; a high molecular nitrogen compound having at least two amino groups selected from primary amino groups, secondary amino groups and tertiary amino groups; and inorganic compound nanoparticles bonded to at least one amino group of the at least two amino groups. The high molecular nitrogen compound is modified by the functional molecules, and the inorganic compound nanoparticles are covered with the high molecular nitrogen compound modified by the functional molecules.

Abstract: A method for producing a calcium phosphate bone filler by preparing a mixed liquid comprising a calcium solution and a phosphoric acid solution in such a manner that a substrate of calcium phosphate exists in the mixed liquid, thereby precipitating calcium phosphate on the substrate to form a coating layer, and heat-treating the resultant composite comprising the substrate and the coating layer.

Abstract: A liquid spray tool for an endoscope includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a liquid storage pouch configured to pool solution to be conveyed into the flexible tube therein, a liquid measuring pouch for measuring an amount of the solution which is arranged between a rear end of the flexible tube and a distal end of the liquid storage pouch, and a first one-way valve arranged between the liquid storage pouch and the liquid measuring pouch, the first one-way valve being configured to allow the solution to pass theretrough from an inside of the liquid storage pouch to an inside of the liquid measuring pouch, and to prevent the solution from passing theretrough from the inside of the liquid measuring pouch to the inside of the liquid storage pouch.

Abstract: A histofluorescent stain for endoscopy having good fluorescent stainability for the inner part of tissues is provided. A histofluorescent stain composition for endoscopy, containing a compound represented by the following Formula (1) wherein R1 and R2, which may be identical or different, each represent an alkyl group having 1 to 5 carbon atoms; and X? represents an anion residue.

Abstract: A fluorescent stain which has a function of clarifying the shape of the surface of the gastrointestinal lumen in the visible light wavelength region, and simultaneously, emitting fluorescence by being excited by light of a specific wavelength, and which is also biologically safe and is suitable for endoscopic observation, is provided. A histofluorescent stain composition for endoscopy, containing a compound represented by the following Formula (1): wherein R1 represents a hydrogen atom or a hydroxyl group; R3 represents a phenyl group or methyl group, to which R2c is bound; one to three of R2a, R2b and R2c represent —SO3M (wherein M represents an alkali metal atom or an alkaline earth metal atom), or —SO3NH4, and when one represents —SO3?, the others represent hydrogen atoms is provided.

Abstract: It is intended to provide means for more clearly showing an image of fluorescent staining of a lumen of the digestive tract. The present invention provides an agent for enhancing a contrast of an image of fluorescent staining of a lumen of the digestive tract with an intravenously administered fluorescent dye, wherein the agent for enhancing a contrast is an agent for a lumen of the digestive tract containing an aqueous solution having a buffer capacity and having a pH of 6 to 10.

Abstract: A composite body of an inorganic compound and cells includes animal cells filled with fine particles of the inorganic compound, and the fine particles of the inorganic compound adhered to an outer portion of the animal cells. A method of producing a composite body of an inorganic compound and cells is also provided, including cultivating animal cells in a culture medium containing fine particles of the inorganic compound, and separating a solid component from the cultivated product.

Abstract: A column for adsorbing a component in a sample has a tubular member through which a sample flows. The column also has a stationary phase housed in the tubular member and formed by an aggregate of a plurality of particles. At least a portion of surfaces of the particles is made of the same material as at least a portion of an inner wall surface of the tubular member so that a component in the sample is adsorbed on both of the surfaces of the particles and the inner wall surface of the tubular member.

Abstract: It is intended to provide a method for fluorescently staining a tissue accurately and clearly by convenient procedures and a staining agent used in this method. The present invention provides a method for fluorescently staining a tissue, comprising treating a tissue with a solution comprising fluorescein or a salt thereof and then fluorescently observing the treated portion under an acidic condition of lower than pH 7.

Abstract: An endoscope for magnified image observation configured to observe a magnified image of in vivo tissue comprises an insertion part configured to be inserted into a body, a magnified image observation port configured to take in the magnified image of the in vivo tissue in one of a state where the magnified image observation port is in contact with the in vivo tissue and a state where the magnified image observation port is in proximity to the in vivo tissue, the observation port being provided at a distal end of the insertion part, and a marking unit configured to mark the in vivo tissue in one of the state where the magnified image observation port is in contact with the in vivo tissue and the state where the magnified image observation port is in proximity to the in vivo tissue.

Abstract: A liquid spray tool for an endoscope includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a liquid storage pouch configured to pool solution to be conveyed into the flexible tube therein, a liquid measuring pouch for measuring an amount of the solution which is arranged between a rear end of the flexible tube and a distal end of the liquid storage pouch, and a first one-way valve arranged between the liquid storage pouch and the liquid measuring pouch, the first one-way valve being configured to allow the solution to pass theretrough from an inside of the liquid storage pouch to an inside of the liquid measuring pouch, and to prevent the solution from passing theretrough from the inside of the liquid measuring pouch to the inside of the liquid storage pouch.

Abstract: A liquid applicator for an endoscope configured to apply liquid to in vivo tissue includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a brush member provided at a distal end of the flexible tube, and a fluid channel formed in the flexible tube to supply the liquid to the brush member.

Abstract: The invention relates to a histostain composition for endoscope containing one or more members selected from colors derived from Monascus. The stain composition is a staining agent which sharpens the shapes of digestive tract lumen surfaces and the like with a light in the visible wavelength range, having a function of being excited by a light of specific wavelength to emit fluorescence, and being biologically safe and suitable for endoscopy.