Abstract: An initial conformation setting unit sets multiple different initial conformations. a solubility feature calculation unit calculates a solubility feature for each molecular simulation for each initial conformation. A partial three-dimensional structural information acquisition unit calculates partial three-dimensional structural information of a molecule in each molecular simulation. Based on a solubility feature and partial three-dimensional structural information for each molecular simulation, a partial structure specification unit specifies a partial structure corresponding to variation in the solubility features. A variation evaluation unit selects a group based on the thermodynamic stability of each group in which the solubility feature is classified based on the partial structure, and calculates variation in the solubility features. When the variation is equal to or greater than a target variation value, a variation determination unit causes multiple new initial conformations to be set.

Abstract: According to one embodiment, a semiconductor device includes a first conductive layer between first and second insulating layers with an oxide semiconductor column extending in the first direction through these layers. A third insulating layer covers the column. The column has a first semiconductor portion at a first position matching the first insulating layer, a second semiconductor portion at a second position matching second insulating layer, and a third semiconductor portion at a third position matching the first conductive layer. The first semiconductor portion is continuous along a second direction between the third insulating layer, the second semiconductor portion is continuous along the second direction between the third insulating layer, but the third semiconductor portion is not continuous between the third insulating layer.

Abstract: A reaction analysis system includes a first flow path through which a reaction fluid, obtained by mixing reactants in a mixer, flows, a second flow path through which the reaction fluid flows and that has higher heat exchange efficiency than the first flow path, a temperature measurer that measures a temperature distribution of the reaction fluid along the first flow path, and a reaction analysis device that specifies a reaction state of the reaction fluid based on a reaction parameter. The reaction parameter is obtained from the measured temperature distribution and indicates the reaction state of the reaction fluid.

Abstract: A reaction analysis device specifies a reaction state of a reaction fluid flowing through a flow reactor. The reaction analysis device includes a processor configured to specify the reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid which is obtained from a temperature distribution of the reaction fluid immediately after a reaction starts in a flow direction of the reaction fluid.

Abstract: A reaction analysis device specifies a reaction state of a reaction fluid flowing through a flow reactor. The reaction analysis device includes a processor configured to specify the reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid which is obtained from a temperature distribution of the reaction fluid immediately after a reaction starts in a flow direction of the reaction fluid.

Abstract: An information input device has a determination portion, a detection portion, and a switching portion. The detection portion includes two areas that plural coils are arranged along a plane. The two areas switch between a folded state facing the areas each other and a two-page spread state not facing the areas each other. When an induced current is not detected in the coils of the two areas in the continuous reception state in which the induced current of the coils can be detected, the determination portion determines that the detection portion is in the two-page spread state. When the induced current is detected in the coils of the two areas in the continuous reception state, the determination portion determines that the detection portion is in the folded state, and the switching portion switches the state of the detection portion from a normal state to a power saving state.

Abstract: An information input device has a determination portion, a detection portion, and a switching portion. The detection portion includes two areas that plural coils are arranged along a plane. The two areas switch between a folded state facing the areas each other and a two-page spread state not facing the areas each other. When an induced current is not detected in the coils of the two areas in the continuous reception state in which the induced current of the coils can be detected, the determination portion determines that the detection portion is in the two-page spread state. When the induced current is detected in the coils of the two areas in the continuous reception state, the determination portion determines that the detection portion is in the folded state, and the switching portion switches the state of the detection portion from a normal state to a power saving state.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are are as defined herein, and wherein the compound comprises at least one F, Cl, Br, I or 123I moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein the compound comprises at least one F, Cl, Br, I or 123I moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein the compound comprises at least one F, Cl, Br, I or 123I moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.

Abstract: This disclosure discloses a label producing apparatus comprising: a housing; a feeding device that feeds a label tape; a printing device that prints desired print; an optical sensor comprising a light projecting device and a light receiving device capable of outputting a detected voltage value; a light-on control portion that controls said optical sensor so that said light projecting device is turned on; an initial value storage device that stores a predetermined initial threshold value; a threshold value correction portion that calculates a corrected threshold value using said initial threshold value; a mark detecting portion that detects a positioning mark by an arrival of said detected voltage value at said corrected threshold value after calculation of said corrected threshold value; a feeding control portion that controls said feeding device; and a print control portion that controls a print operation of said printing device.

Abstract: This disclosure discloses a label producing apparatus comprising: a housing; a feeding device that feeds a label tape; a printing device that prints desired print; an optical sensor comprising a light projecting device and a light receiving device capable of outputting a detected voltage value; a light-on control portion that controls said optical sensor so that said light projecting device is turned on; an initial value storage device that stores a predetermined initial threshold value; a threshold value correction portion that calculates a corrected threshold value using said initial threshold value; a mark detecting portion that detects a positioning mark by an arrival of said detected voltage value at said corrected threshold value after calculation of said corrected threshold value; a feeding control portion that controls said feeding device; and a print control portion that controls a print operation of said printing device.