Patents by Inventor Yusuke Nishiyama
Yusuke Nishiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11609194Abstract: Nuclear spins of particular atoms (14N) which distinctively exist in a crystal of an active pharmaceutical ingredient is manipulated, so that an initial magnetization (modulated magnetization) is caused in nearby hydrogen atoms which exist near the particular atoms in the crystal. The initial magnetization of the nearby hydrogen atoms is spread to peripheral hydrogen atoms which exist at a periphery of the nearby hydrogen atoms in the crystal. A magnetization which is spread in the crystal is directly or indirectly observed.Type: GrantFiled: December 10, 2020Date of Patent: March 21, 2023Assignees: JEOL Ltd., RIKENInventor: Yusuke Nishiyama
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Patent number: 11067518Abstract: A whole measurement process includes a plurality of step combinations. Each of the step combinations is composed of a solution-state measurement step and a solid-state measurement step. In the solution-state measurement step, solution-state NMR measurement is performed such that magnetization that is to be used in the solid-state measurement step remains. In the solid-state measurement step, solid-state NMR measurement is performed by using the magnetization that remains. No waiting time for recovering magnetization is provided between the solution-state measurement step and the solid-state measurement step. The solid-state measurement step may be performed earlier, and the solution-state measurement step may be performed later. Alternatively, the two steps may be performed simultaneously.Type: GrantFiled: December 11, 2017Date of Patent: July 20, 2021Assignees: RIKEN, JEOL Ltd.Inventor: Yusuke Nishiyama
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Publication number: 20210181130Abstract: Nuclear spins of particular atoms (14N) which distinctively exist in a crystal of an active pharmaceutical ingredient is manipulated, so that an initial magnetization (modulated magnetization) is caused in nearby hydrogen atoms which exist near the particular atoms in the crystal. The initial magnetization of the nearby hydrogen atoms is spread to peripheral hydrogen atoms which exist at a periphery of the nearby hydrogen atoms in the crystal. A magnetization which is spread in the crystal is directly or indirectly observed.Type: ApplicationFiled: December 10, 2020Publication date: June 17, 2021Inventor: Yusuke Nishiyama
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Patent number: 10955366Abstract: An electron diffraction apparatus measures an overall structure of a crystal of a specimen by electron diffraction. An NMR apparatus measures a local structure of the crystal by NMR measurement. An analysis apparatus combines the overall structure and the local structure to specify a structure of the crystal.Type: GrantFiled: June 28, 2019Date of Patent: March 23, 2021Assignees: JEOL Ltd., RIKENInventors: Koji Yonekura, Yusuke Nishiyama
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Publication number: 20200003710Abstract: An electron diffraction apparatus measures an overall structure of a crystal of a specimen by electron diffraction. An NMR apparatus measures a local structure of the crystal by NMR measurement. An analysis apparatus combines the overall structure and the local structure to specify a structure of the crystal.Type: ApplicationFiled: June 28, 2019Publication date: January 2, 2020Inventors: Koji Yonekura, Yusuke Nishiyama
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Publication number: 20180164234Abstract: A whole measurement process includes a plurality of step combinations. Each of the step combinations is composed of a solution-state measurement step and a solid-state measurement step. In the solution-state measurement step, solution-state NMR measurement is performed such that magnetization that is to be used in the solid-state measurement step remains. In the solid-state measurement step, solid-state NMR measurement is performed by using the magnetization that remains. No waiting time for recovering magnetization is provided between the solution-state measurement step and the solid-state measurement step. The solid-state measurement step may be performed earlier, and the solution-state measurement step may be performed later. Alternatively, the two steps may be performed simultaneously.Type: ApplicationFiled: December 11, 2017Publication date: June 14, 2018Inventor: Yusuke Nishiyama
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Patent number: 9784809Abstract: A method is offered which permits NMR measurements of integer spin nuclei to be performed at higher sensitivity than heretofore. In particular, the method enables high-resolution multidimensional correlation NMR measurements on integer spin nucleus S having integer spin S and nucleus I of other spin species. The method starts with applying an RF magnetic field having a frequency that is n times (where n is an integer equal to or greater than 2) the Larmor frequency of the integer spin nucleus S to the spin S. Magnetization transfer is effected between the nucleus I and the integer spin nucleus S.Type: GrantFiled: April 10, 2013Date of Patent: October 10, 2017Assignee: JEOL Ltd.Inventors: Yusuke Nishiyama, Takahiro Nemoto
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Patent number: 9778332Abstract: A spinning controller has an arithmetic unit (18) and a controller (20). The arithmetic unit (18) establishes gate periods Tg for a pulse sequence signal (110) produced concomitantly with spinning of a sample tube (40) and obtains a count value (Ns) by counting the number of pulses falling within each gate period Tg. The arithmetic unit (18) has functions of finding differences in time from each gate period Tg to the pulse sequence signal (110) occurring around the starting point and ending point of each gate period Tg by making use of a high-speed clock signal (120) and of correcting the duration of the gate period Tg, based on the differences in time.Type: GrantFiled: April 16, 2014Date of Patent: October 3, 2017Assignee: JEOL Ltd.Inventors: Tomio Ozaku, Yusuke Nishiyama
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Patent number: 9389287Abstract: In a nuclear magnetic resonance (NMR) spectrometer, a sample spins about an axis tilted at a magic angle, a corrective magnetic field generating portion produces a corrective magnetic field, and a control portion controls the operation of the corrective magnetic field generating portion. An arithmetic unit included in the control portion uses at least one of BZ(1), B1(1)e, and B1(1)o or the linear sum of at least two of them as the first-order magnetic field component of the corrective magnetic field, uses at least one of B2(2)e, B2(2)o, B2(1)e, and B2(1)o or the linear sum of at least two of them as the second-order magnetic field component of the corrective magnetic field, and uses at least one of BZ(3), B3(1)e, B3(1)o, B3(2)e, B3(2)o, B3(3)e, and B3(3)o or the linear sum of at least two of them as the third-order magnetic field component of the corrective magnetic field.Type: GrantFiled: February 6, 2012Date of Patent: July 12, 2016Assignee: JEOL Ltd.Inventor: Yusuke Nishiyama
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Publication number: 20140312900Abstract: A spinning controller has an arithmetic unit (18) and a controller (20). The arithmetic unit (18) establishes gate periods Tg for a pulse sequence signal (110) produced concomitantly with spinning of a sample tube (40) and obtains a count value (Ns) by counting the number of pulses falling within each gate period Tg. The arithmetic unit (18) has functions of finding differences in time from each gate period Tg to the pulse sequence signal (110) occurring around the starting point and ending point of each gate period Tg by making use of a high-speed clock signal (120) and of correcting the duration of the gate period Tg, based on the differences in time.Type: ApplicationFiled: April 16, 2014Publication date: October 23, 2014Applicant: JEOL Ltd.Inventors: Tomio Ozaku, Yusuke Nishiyama
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Patent number: 8798949Abstract: A spectrometer has: Accumulation means to obtain a data set containing N data points, repeating the measurement M times to obtain M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN), and accumulating the M spectral data sets or time-domain data sets. Means for creating sets S1 (dn) to SM (dn) of the data points contained in the M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN). Correlation computing means for finding correlations. Computing means for finding either the product of an accumulated or anticipated spectrum.Type: GrantFiled: May 17, 2011Date of Patent: August 5, 2014Assignee: JEOL Resonance Inc.Inventors: Kiyonori Takegoshi, Yusuke Nishiyama
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Publication number: 20140070806Abstract: A method of NMR measurement which achieves background suppression based on a technique employing differences in RF magnetic field strength while alleviating the problem that less latitude is allowed in setting the number of signal accumulations. This method suppresses a background-derived signal emanating from the material of an NMR probe. The method starts with applying an RF pulse sequence consisting of a 90° pulse and subsequent one or more 180° pulses to a sample to induce an NMR signal and detecting the signal. This application is repeated while varying the RF phases of the pulses to induce NMR signals in accordance with a cogwheel phase-cycling scheme to induce NMR signals. The NMR signals are detected. The detected NMR signals are accumulated.Type: ApplicationFiled: September 4, 2013Publication date: March 13, 2014Applicant: JEOL Resonance Inc.Inventors: Yusuke Nishiyama, Michael H. Frey
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Publication number: 20130271138Abstract: A method is offered which permits NMR measurements of integer spin nuclei to be performed at higher sensitivity than heretofore. In particular, the method enables high-resolution multidimensional correlation NMR measurements on integer spin nucleus S having integer spin S and nucleus I of other spin species. The method starts with applying an RF magnetic field having a frequency that is n times (where n is an integer equal to or greater than 2) the Larmor frequency of the integer spin nucleus S to the spin S. Magnetization transfer is effected between the nucleus I and the integer spin nucleus S.Type: ApplicationFiled: April 10, 2013Publication date: October 17, 2013Applicant: JEOL Resonance Inc.Inventors: Yusuke Nishiyama, Takahiro Nemoto
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Publication number: 20130030749Abstract: In a nuclear magnetic resonance (NMR) spectrometer, a sample spins about an axis tilted at a magic angle, a corrective magnetic field generating portion produces a corrective magnetic field, and a control portion controls the operation of the corrective magnetic field generating portion. An arithmetic unit included in the control portion uses at least one of BZ(1), B1(1)e, and B1(1)o or the linear sum of at least two of them as the first-order magnetic field component of the corrective magnetic field, uses at least one of B2(2)e, B2(2)o, B2(1)e, and B2(1)o or the linear sum of at least two of them as the second-order magnetic field component of the corrective magnetic field, and uses at least one of BZ(3), B3(1)e, B3(1)o, B3(2)e, B3(2)o, B3(3)e, and B3(3)o or the linear sum of at least two of them as the third-order magnetic field component of the corrective magnetic field.Type: ApplicationFiled: February 6, 2012Publication date: January 31, 2013Applicant: JEOL RESONANCE INC.Inventor: Yusuke Nishiyama
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Patent number: 8072213Abstract: An NMR measurement method adapted for measurements on solid mixture samples starts with irradiating a pulse sequence to the sample in order to measure the longitudinal magnetization relaxation times of nuclei possessing homogeneous longitudinal magnetization relaxation times (step 1). After a lapse of a given period of time t, a high-resolution NMR spectrum is acquired by nullifying spin diffusion across the nuclei (step 2). The steps 1 and 2 are repeated while varying the period of time t. The high-resolution NMR spectra are classified according to value of longitudinal magnetization relaxation time by inverse Laplace transform.Type: GrantFiled: September 17, 2009Date of Patent: December 6, 2011Assignee: JEOL Resonance Inc.Inventor: Yusuke Nishiyama
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Publication number: 20110288802Abstract: A spectrometer has: Accumulation means to obtain a data set containing N data points, repeating the measurement M times to obtain M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN), and accumulating the M spectral data sets or time-domain data sets. Means for creating sets S1 (dn) to SM (dn) of the data points contained in the M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN). Correlation computing means for finding correlations. Computing means for finding either the product of an accumulated or anticipated spectrum.Type: ApplicationFiled: May 17, 2011Publication date: November 24, 2011Applicant: JEOL RESONANCE INC.Inventors: Kiyonori Takegoshi, Yusuke Nishiyama
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Publication number: 20100072995Abstract: An NMR measurement method adapted for measurements on solid mixture samples starts with irradiating a pulse sequence to the sample in order to measure the longitudinal magnetization relaxation times of nuclei possessing homogeneous longitudinal magnetization relaxation times (step 1). After a lapse of a given period of time t, a high-resolution NMR spectrum is acquired by nullifying spin diffusion across the nuclei (step 2). The steps 1 and 2 are repeated while varying the period of time t. The high-resolution NMR spectra are classified according to value of longitudinal magnetization relaxation time by inverse Laplace transform.Type: ApplicationFiled: September 17, 2009Publication date: March 25, 2010Applicant: JEOL LTD.Inventor: Yusuke Nishiyama