Patents by Inventor Yusuke Nishiyama

Yusuke Nishiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11609194
    Abstract: Nuclear spins of particular atoms (14N) which distinctively exist in a crystal of an active pharmaceutical ingredient is manipulated, so that an initial magnetization (modulated magnetization) is caused in nearby hydrogen atoms which exist near the particular atoms in the crystal. The initial magnetization of the nearby hydrogen atoms is spread to peripheral hydrogen atoms which exist at a periphery of the nearby hydrogen atoms in the crystal. A magnetization which is spread in the crystal is directly or indirectly observed.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: March 21, 2023
    Assignees: JEOL Ltd., RIKEN
    Inventor: Yusuke Nishiyama
  • Patent number: 11067518
    Abstract: A whole measurement process includes a plurality of step combinations. Each of the step combinations is composed of a solution-state measurement step and a solid-state measurement step. In the solution-state measurement step, solution-state NMR measurement is performed such that magnetization that is to be used in the solid-state measurement step remains. In the solid-state measurement step, solid-state NMR measurement is performed by using the magnetization that remains. No waiting time for recovering magnetization is provided between the solution-state measurement step and the solid-state measurement step. The solid-state measurement step may be performed earlier, and the solution-state measurement step may be performed later. Alternatively, the two steps may be performed simultaneously.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: July 20, 2021
    Assignees: RIKEN, JEOL Ltd.
    Inventor: Yusuke Nishiyama
  • Publication number: 20210181130
    Abstract: Nuclear spins of particular atoms (14N) which distinctively exist in a crystal of an active pharmaceutical ingredient is manipulated, so that an initial magnetization (modulated magnetization) is caused in nearby hydrogen atoms which exist near the particular atoms in the crystal. The initial magnetization of the nearby hydrogen atoms is spread to peripheral hydrogen atoms which exist at a periphery of the nearby hydrogen atoms in the crystal. A magnetization which is spread in the crystal is directly or indirectly observed.
    Type: Application
    Filed: December 10, 2020
    Publication date: June 17, 2021
    Inventor: Yusuke Nishiyama
  • Patent number: 10955366
    Abstract: An electron diffraction apparatus measures an overall structure of a crystal of a specimen by electron diffraction. An NMR apparatus measures a local structure of the crystal by NMR measurement. An analysis apparatus combines the overall structure and the local structure to specify a structure of the crystal.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: March 23, 2021
    Assignees: JEOL Ltd., RIKEN
    Inventors: Koji Yonekura, Yusuke Nishiyama
  • Publication number: 20200003710
    Abstract: An electron diffraction apparatus measures an overall structure of a crystal of a specimen by electron diffraction. An NMR apparatus measures a local structure of the crystal by NMR measurement. An analysis apparatus combines the overall structure and the local structure to specify a structure of the crystal.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 2, 2020
    Inventors: Koji Yonekura, Yusuke Nishiyama
  • Publication number: 20180164234
    Abstract: A whole measurement process includes a plurality of step combinations. Each of the step combinations is composed of a solution-state measurement step and a solid-state measurement step. In the solution-state measurement step, solution-state NMR measurement is performed such that magnetization that is to be used in the solid-state measurement step remains. In the solid-state measurement step, solid-state NMR measurement is performed by using the magnetization that remains. No waiting time for recovering magnetization is provided between the solution-state measurement step and the solid-state measurement step. The solid-state measurement step may be performed earlier, and the solution-state measurement step may be performed later. Alternatively, the two steps may be performed simultaneously.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 14, 2018
    Inventor: Yusuke Nishiyama
  • Patent number: 9784809
    Abstract: A method is offered which permits NMR measurements of integer spin nuclei to be performed at higher sensitivity than heretofore. In particular, the method enables high-resolution multidimensional correlation NMR measurements on integer spin nucleus S having integer spin S and nucleus I of other spin species. The method starts with applying an RF magnetic field having a frequency that is n times (where n is an integer equal to or greater than 2) the Larmor frequency of the integer spin nucleus S to the spin S. Magnetization transfer is effected between the nucleus I and the integer spin nucleus S.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: October 10, 2017
    Assignee: JEOL Ltd.
    Inventors: Yusuke Nishiyama, Takahiro Nemoto
  • Patent number: 9778332
    Abstract: A spinning controller has an arithmetic unit (18) and a controller (20). The arithmetic unit (18) establishes gate periods Tg for a pulse sequence signal (110) produced concomitantly with spinning of a sample tube (40) and obtains a count value (Ns) by counting the number of pulses falling within each gate period Tg. The arithmetic unit (18) has functions of finding differences in time from each gate period Tg to the pulse sequence signal (110) occurring around the starting point and ending point of each gate period Tg by making use of a high-speed clock signal (120) and of correcting the duration of the gate period Tg, based on the differences in time.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: October 3, 2017
    Assignee: JEOL Ltd.
    Inventors: Tomio Ozaku, Yusuke Nishiyama
  • Patent number: 9389287
    Abstract: In a nuclear magnetic resonance (NMR) spectrometer, a sample spins about an axis tilted at a magic angle, a corrective magnetic field generating portion produces a corrective magnetic field, and a control portion controls the operation of the corrective magnetic field generating portion. An arithmetic unit included in the control portion uses at least one of BZ(1), B1(1)e, and B1(1)o or the linear sum of at least two of them as the first-order magnetic field component of the corrective magnetic field, uses at least one of B2(2)e, B2(2)o, B2(1)e, and B2(1)o or the linear sum of at least two of them as the second-order magnetic field component of the corrective magnetic field, and uses at least one of BZ(3), B3(1)e, B3(1)o, B3(2)e, B3(2)o, B3(3)e, and B3(3)o or the linear sum of at least two of them as the third-order magnetic field component of the corrective magnetic field.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: July 12, 2016
    Assignee: JEOL Ltd.
    Inventor: Yusuke Nishiyama
  • Publication number: 20140312900
    Abstract: A spinning controller has an arithmetic unit (18) and a controller (20). The arithmetic unit (18) establishes gate periods Tg for a pulse sequence signal (110) produced concomitantly with spinning of a sample tube (40) and obtains a count value (Ns) by counting the number of pulses falling within each gate period Tg. The arithmetic unit (18) has functions of finding differences in time from each gate period Tg to the pulse sequence signal (110) occurring around the starting point and ending point of each gate period Tg by making use of a high-speed clock signal (120) and of correcting the duration of the gate period Tg, based on the differences in time.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: JEOL Ltd.
    Inventors: Tomio Ozaku, Yusuke Nishiyama
  • Patent number: 8798949
    Abstract: A spectrometer has: Accumulation means to obtain a data set containing N data points, repeating the measurement M times to obtain M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN), and accumulating the M spectral data sets or time-domain data sets. Means for creating sets S1 (dn) to SM (dn) of the data points contained in the M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN). Correlation computing means for finding correlations. Computing means for finding either the product of an accumulated or anticipated spectrum.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: August 5, 2014
    Assignee: JEOL Resonance Inc.
    Inventors: Kiyonori Takegoshi, Yusuke Nishiyama
  • Publication number: 20140070806
    Abstract: A method of NMR measurement which achieves background suppression based on a technique employing differences in RF magnetic field strength while alleviating the problem that less latitude is allowed in setting the number of signal accumulations. This method suppresses a background-derived signal emanating from the material of an NMR probe. The method starts with applying an RF pulse sequence consisting of a 90° pulse and subsequent one or more 180° pulses to a sample to induce an NMR signal and detecting the signal. This application is repeated while varying the RF phases of the pulses to induce NMR signals in accordance with a cogwheel phase-cycling scheme to induce NMR signals. The NMR signals are detected. The detected NMR signals are accumulated.
    Type: Application
    Filed: September 4, 2013
    Publication date: March 13, 2014
    Applicant: JEOL Resonance Inc.
    Inventors: Yusuke Nishiyama, Michael H. Frey
  • Publication number: 20130271138
    Abstract: A method is offered which permits NMR measurements of integer spin nuclei to be performed at higher sensitivity than heretofore. In particular, the method enables high-resolution multidimensional correlation NMR measurements on integer spin nucleus S having integer spin S and nucleus I of other spin species. The method starts with applying an RF magnetic field having a frequency that is n times (where n is an integer equal to or greater than 2) the Larmor frequency of the integer spin nucleus S to the spin S. Magnetization transfer is effected between the nucleus I and the integer spin nucleus S.
    Type: Application
    Filed: April 10, 2013
    Publication date: October 17, 2013
    Applicant: JEOL Resonance Inc.
    Inventors: Yusuke Nishiyama, Takahiro Nemoto
  • Publication number: 20130030749
    Abstract: In a nuclear magnetic resonance (NMR) spectrometer, a sample spins about an axis tilted at a magic angle, a corrective magnetic field generating portion produces a corrective magnetic field, and a control portion controls the operation of the corrective magnetic field generating portion. An arithmetic unit included in the control portion uses at least one of BZ(1), B1(1)e, and B1(1)o or the linear sum of at least two of them as the first-order magnetic field component of the corrective magnetic field, uses at least one of B2(2)e, B2(2)o, B2(1)e, and B2(1)o or the linear sum of at least two of them as the second-order magnetic field component of the corrective magnetic field, and uses at least one of BZ(3), B3(1)e, B3(1)o, B3(2)e, B3(2)o, B3(3)e, and B3(3)o or the linear sum of at least two of them as the third-order magnetic field component of the corrective magnetic field.
    Type: Application
    Filed: February 6, 2012
    Publication date: January 31, 2013
    Applicant: JEOL RESONANCE INC.
    Inventor: Yusuke Nishiyama
  • Patent number: 8072213
    Abstract: An NMR measurement method adapted for measurements on solid mixture samples starts with irradiating a pulse sequence to the sample in order to measure the longitudinal magnetization relaxation times of nuclei possessing homogeneous longitudinal magnetization relaxation times (step 1). After a lapse of a given period of time t, a high-resolution NMR spectrum is acquired by nullifying spin diffusion across the nuclei (step 2). The steps 1 and 2 are repeated while varying the period of time t. The high-resolution NMR spectra are classified according to value of longitudinal magnetization relaxation time by inverse Laplace transform.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: December 6, 2011
    Assignee: JEOL Resonance Inc.
    Inventor: Yusuke Nishiyama
  • Publication number: 20110288802
    Abstract: A spectrometer has: Accumulation means to obtain a data set containing N data points, repeating the measurement M times to obtain M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN), and accumulating the M spectral data sets or time-domain data sets. Means for creating sets S1 (dn) to SM (dn) of the data points contained in the M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN). Correlation computing means for finding correlations. Computing means for finding either the product of an accumulated or anticipated spectrum.
    Type: Application
    Filed: May 17, 2011
    Publication date: November 24, 2011
    Applicant: JEOL RESONANCE INC.
    Inventors: Kiyonori Takegoshi, Yusuke Nishiyama
  • Publication number: 20100072995
    Abstract: An NMR measurement method adapted for measurements on solid mixture samples starts with irradiating a pulse sequence to the sample in order to measure the longitudinal magnetization relaxation times of nuclei possessing homogeneous longitudinal magnetization relaxation times (step 1). After a lapse of a given period of time t, a high-resolution NMR spectrum is acquired by nullifying spin diffusion across the nuclei (step 2). The steps 1 and 2 are repeated while varying the period of time t. The high-resolution NMR spectra are classified according to value of longitudinal magnetization relaxation time by inverse Laplace transform.
    Type: Application
    Filed: September 17, 2009
    Publication date: March 25, 2010
    Applicant: JEOL LTD.
    Inventor: Yusuke Nishiyama